University of Kansas Alzheimer's Disease Core Center

这是堪萨斯大学（KU）研究人员的阿尔茨海默病核心中心（ADCC）应用程序。在过去的五年里，KU团队开发了托管ADCC所需的基础设施。已经建立了纵向特征的阿尔茨海默病（AD）和年龄匹配的对照队列，这些队列支持了许多研究项目。我们的研究队列已经根据统一数据集（UDS）指南进行了神经心理学表征，并在研究专用的神经影像中心进行了神经影像学检查。每一步都是在专家统计支助和数据库管理投入的配合下规划的。精心策划的对非专业人群和当地医疗保健专业人员的外展活动促进了受试者的招募、保留，并提高了整个堪萨斯城（KC）都会区（美国第29大都会区）对我们AD研究项目的认识。 KU ADCC由五个NIA授权的ADCC核心，一个神经影像核心和一个线粒体基因组学和代谢核心组成。这种基础设施有助于我们追求我们的主要目标，有效和全面地支持AD和AD相关的研究在KU。为此，KU ADCC服务已经扩展了KU的AD研究组合，我们目前保持着多样化的支持研究项目组合。KU ADCC的第二个目标是提供先进的服务，使和促进突破性的AD，AD相关和大脑衰老代谢研究。我们提供的专业知识和高度集成的跨学科服务将帮助AD研究领域定义健身，代谢和线粒体如何独立和共同影响AD的进展和结果。我们相信，将我们的专业知识纳入ADC系统将证明是实用和有价值的，加强现有的ADC系统，并推进AD研究领域。

This Is an Alzheimer's Disease Core Center (ADCC) application from investigators at the University of Kansas (KU). Over the past five years the KU team has developed the infrastructure needed to host an ADCC. Longitudinally characterized Alzheimer's disease (AD) and age-matched control cohorts have been established and these cohorts have supported numerous research projects. Our research cohorts have been characterized neuropsychologically per Uniform Data Set (UDS) guidelines and neuroimaged at a research-dedicated neuroimaging Center. Every step has been planned in conjunction with expert statistical support and database management input. Carefully orchestrated outreach to the lay population and local healthcare professionals has facilitated subject recruitment, retention, and raised awareness of our AD research program throughout the Kansas City (KC) metro area, the 29th largest metro area in the USA. The KU ADCC consists of the five NIA-mandated ADCC cores, a Neuroimaging Core, and a Mitochondrial Genomics and Metabolism Core. This infrastructure helps us pursue our principal aim of effectively and comprehensively supporting AD and AD-related research at KU. To this end KU ADCC services have already invigorated KU's AD research portfolio and we currently maintain a diverse portfolio of supported research projects. A second aim of the KU ADCC is to provide advanced services that enable and facilitate ground-breaking AD, AD-related, and brain aging metabolism research. Our expertise and the highly integrated, Inter-disciplinary services we provide will help the AD research field define how fitness, metabolism, and mitochondria independently and collectively influence progression and outcome in AD. We are confident that incorporating our expertise within the ADC system will prove both practical and valuable, strengthen the existing ADC system, and advance the AD research field.