Alzheimer's Disease Prevention Among African Americans Through Culturally Tailored Education and Outreach

通过针对文化的教育和宣传来预防非裔美国人的阿尔茨海默病

• 批准号: 9921593
• 负责人: RUSSELL H. SWERDLOW
• 金额: $ 10.69万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9921593
• 关键词: Address; African American; Aging; Alzheimer disease prevention; Alzheimer' s Disease; Automobile Driving; Bioenergetics; Biological; Biological Markers; Brain; Brain Diseases; Cancer Center; Clinical; Clinical Services; Clinical Trials; Clinical and Translational Science Awards; Collaborations; Communities; Complement; Complex; Data Set; Development; Diagnosis; Dietary Intervention; Education; Education and Outreach; Energy Metabolism; Environment; Etiology; Faculty Recruitment; Fostering; Foundations; Functional disorder; Funding; Genes; Goals; Growth; Home environment; Human Resources; Individual; Infrastructure; Institutes; Institution; International; Intervention; Investments; Kansas; Knowledge; Lead; Link; Measures; Mission; Mitochondria; Neurologic; Neurosciences; Participant; Pathogenesis; Pharmacology; Physical Exercise; Positioning Attribute; Potential Energy; Research; Research Infrastructure; Research Personnel; Role; Services; Site; Specimen; Testing; Therapeutic Effect; Training; Universities; Work; aging brain; brain health; brain tissue; clinical care; clinical practice; exercise intervention; innovation; interest; novel; prevent; programs; research study; stem; therapeutic evaluation

PROJECT SUMMARY: OVERALL The University of Kansas Alzheimer's Disease Center (KU ADC) promotes research into Alzheimer's disease (AD), brain disorders relevant to AD, and brain aging. We provide support, services, datasets, and biospecimens to institutional, regional, national, and international investigators. The KU ADC transforms AD-relevant research at our home institution and is an indispensable part of the KU neuroscience landscape. We benefit from and enhance an institutional T32 program, receive regular support from an institutional neuroscientist training fund, work closely with KU departments on neuroscientist faculty recruitment, and are a key component of the KU Institute for Neurologic Discoveries (KU IND). We further maintain interactive collaborations with other KU entities including the KU Landon Center on Aging (LCOA), Clinical Translational Science Award (CTSA) Center, NeuroNext site, and KU Cancer Center. We create AD-related clinical and educational infrastructure, making us a vital community and regional set-piece. While the KU ADC promotes an array of AD research, a prominent Center objective is to support, promote, and advance studies that address the causes and consequences of altered energy metabolism in aging and AD. Changes in energy metabolism (i.e, bioenergetics) have been linked to brain aging and AD. The KU ADC has developed a unique infrastructure that enables innovative research pertinent to basic, translational, and clinical energy metabolism-relevant questions. We are uniquely positioned to explore how altered energy metabolism contributes to brain aging and AD, and test the therapeutic potential of energy metabolism manipulations for the treatment of AD. We currently support state of the art programs that are testing the effects of physical exercise and dietary interventions on brain health, developing pharmacologic approaches to manipulate brain energy metabolism, exploring the contribution of mitochondrial genes to AD, and validating mitochondrial and other energy metabolism-related biomarkers. By advancing our understanding of energy metabolism's role in AD at multiple levels, developing novel capabilities, and testing innovative approaches intended to measure, characterize, and treat AD energy metabolism dysfunction we address a critical AD knowledge gap and position ourselves to potentially shift current AD research and clinical practice paradigms. Our first funding cycle (2011-16) focused on Center infrastructure, and our second funding cycle will extend our portfolio of federally funded investigator projects to further complement the first class, innovative research programs we currently support. Through these efforts and the research infrastructure we provide, we will pursue our mission to develop interventions that can prevent and treat AD. We will accomplish these goals through the following Specific Aims: (1) Advance AD and brain aging research; (2) Serve as a Midwestern hub for AD research, clinical care, and education; and (3) Enhance the ADC network.

项目摘要：总体 堪萨斯大学阿尔茨海默氏病中心（KU ADC）促进了对阿尔茨海默氏症的研究 疾病（AD），与AD相关的脑疾病以及脑老化。我们提供支持，服务，数据集和 机构，地区，国家和国际调查人员的生物测量。 KU ADC在我们的家庭机构中改变了与广告相关的研究，这是必不可少的一部分 KU神经科学景观。我们从机构T32计划中受益并增强 机构神经科学家培训基金的支持，与KU部门紧密合作。 教师招聘，是KU神经系统发现研究所（KU IND）的关键组成部分。我们 进一步维护与其他KU实体（包括KU Landon衰老中心）的互动合作 （LCOA），临床转化科学奖（CTSA）中心，Neuronext站点和KU癌症中心。我们 创建与广告相关的临床和教育基础设施，使我们成为重要的社区和区域套件。 尽管KU ADC促进了一系列广告研究，但一个重要的中心目标是支持，促进，促进， 并提出研究，以解决衰老和衰老中能量代谢改变的原因和后果 广告。能量代谢的变化（即生物能学）与大脑衰老和AD有关。 KU ADC 已经开发了一种独特的基础设施，使创新研究与基本，翻译和 与临床能源代谢有关的问题。我们有独特的位置，可以探索如何改变能量 代谢有助于大脑衰老和AD，并测试能量代谢的治疗潜力 处理AD的操作。我们目前支持正在测试的最新计划 体育锻炼和饮食干预措施对大脑健康的影响，开发药理学方法 操纵脑能量代谢，探索线粒体基因对AD的贡献并验证 线粒体和其他与代谢相关的生物标志物。通过促进我们对能量的理解 代谢在多个层面上的广告中的作用，开发新型能力并测试创新方法 旨在衡量，表征和治疗AD能量代谢功能障碍我们解决关键广告 知识差距并定位自己，以改变当前的广告研究和临床实践范例。 我们的第一个资金周期（2011-16）重点是中心基础设施，我们的第二个融资周期将延长 我们由联邦资助的调查员项目组合，以进一步补充一流的创新研究 我们目前支持的程序。通过这些努力和我们提供的研究基础设施，我们将 追求我们的使命，以制定可以预防和治疗广告的干预措施。我们将实现这些目标 通过以下特定目的：（1）提前AD和大脑衰老研究； （2）用作中西部集线器 用于广告研究，临床护理和教育； （3）增强ADC网络。