Mentoring Imaging Research in Early AD

指导早期 AD 的影像学研究

• 批准号: 8306146
• 负责人: REISA A. SPERLING
• 金额: $ 13.96万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8306146
• 关键词: Aging; Alzheimer' s Disease; Amyloid; Amyloid deposition; Anatomy; Atrophic; Award; Biometry; Brain; Cerebrovascular Disorders; Clinical; Clinical Investigator; Clinical Research; Cognitive aging; Commit; Data; Dementia; Disease; Doctor of Medicine; Early treatment; Educational workshop; Epidemiology; Exhibits; Foundations; Foxes; Functional Magnetic Resonance Imaging; Funding; General Hospitals; Generations; Goals; Grant; Hippocampus (Brain); Hospitals; Image; Imaging Device; Imaging Techniques; Impaired cognition; Impairment; Individual; Inferior; Institutes; Interdisciplinary Study; Language; Link; Longitudinal Studies; Magnetic Resonance Imaging; Massachusetts; Measures; Memory; Memory impairment; Mentors; Mentorship; Methodology; Mid-Career Clinical Scientist Award (K24); Neurology; Parietal; Pathology; Patients; Performance; Positron-Emission Tomography; Principal Investigator; Process; Public Health Schools; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Rest; Staging; Task Performances; Techniques; Technology; Time; Training; United States National Institutes of Health; Woman; Work; Writing; amyloid imaging; amyloid pathology; career; career development; cognitive function; cognitive neuroscience; distributed memory; effective therapy; executive function; imaging modality; interest; medical schools; memory process; molecular imaging; multimodality; network dysfunction; neuroimaging; neuropsychological; normal aging; patient oriented; patient oriented research; pre-clinical; professor; programs; public health relevance; relating to nervous system; response

DESCRIPTION (provided by applicant): This is a revised application for a K24 Midcareer Investigator Award in aging and Alzheimer's disease (AD) patient-oriented research. The candidate, Reisa A. Sperling, M.D. M.MSc., is an Associate Professor of Neurology at Harvard Medical School with a strong early track record as a productive clinical investigator and research mentor. The overarching aims of the candidate's research program are to: 1) elucidate the neural underpinnings of memory impairment in aging and early AD, 2) link the pathophysiological process of AD to the early clinical manifestations, and 3) develop sensitive imaging markers to track the progression of AD in the preclinical stages, enabling earlier intervention with disease-modifying treatments. The candidate has several ongoing NIH and foundation-funded multimodality imaging research projects in MCI and early AD, as well as a pending Program Project on aging and amyloid, which was recently very favorably reviewed. The applicant will use her funded research as a platform for the mentorship of new patient-oriented investigators and to promote a multidisciplinary research approach to the study of cognitive aging and early AD. The applicant's mentees will have the opportunity to train in functional, structural, and molecular imaging techniques, cognitive neuroscience, neuropsychological assessment of early dementia, biostatistics, and epidemiological aspects of longitudinal study design as they apply to aging and AD patient research, drawing expertise from an outstanding group of collaborators. Trainees will also be able to participate in research seminars, statistical training and imaging workshops provided by T32 and other training grants, career development and grant- writing workshops as part of the newly funded CTSA at Harvard, and didactic course work at Brigham and Women's Hospital, Massachusetts General Hospital, Massachusetts Institute of Technology, and the Harvard School of Public Health. The candidate herself will acquire additional expertise in advanced statistical and epidemiological methodology related to her ongoing research, and will expand her research into resting functional connectivity techniques as part of new research proposed for the K24 award. The K24 will be instrumental in advancing the candidate's research career in neuroimaging of early AD, and in protecting her time to mentor a new generation of investigators committed to AD patient-oriented research. PUBLIC HEALTH RELEVANCE: The applicant's research program seeks to understand the cause of memory problems in older individuals, to develop imaging tools to detect the earliest signs of Alzheimer's disease (AD), and to use these imaging tools to find effective treatments for AD. The applicant will use the K24 award to expand her imaging research program and to train new investigators for clinical research careers in patient-oriented AD research.

描述(由申请人提供)：这是K24职业中期调查员奖的修订申请，研究对象是老龄化和阿尔茨海默病(AD)患者。候选人Reisa A.Sperling，医学博士，医学硕士，哈佛医学院神经学副教授，作为一名富有成效的临床研究员和研究导师，有着良好的早期记录。候选人研究计划的总体目标是：1)阐明衰老和早期AD记忆障碍的神经基础，2)将AD的病理生理过程与早期临床表现联系起来，3)开发灵敏的成像标记物来跟踪AD临床前阶段的进展，从而能够通过疾病修改治疗进行早期干预。候选人在MCI和AD早期有几个正在进行的NIH和基金会资助的多模式成像研究项目，以及一个正在进行的关于衰老和淀粉样蛋白的计划项目，该项目最近得到了非常有利的评价。申请者将利用她资助的研究作为指导新的以患者为导向的研究人员的平台，并促进多学科研究方法来研究认知老化和早期阿尔茨海默病。申请者的受训者将有机会接受功能、结构和分子成像技术、认知神经科学、早期痴呆症的神经心理学评估、生物统计学和纵向研究设计的流行病学方面的培训，因为他们应用于老龄化和AD患者的研究，从一群杰出的合作者那里汲取专业知识。学员还将能够参加由T32和其他培训补助金提供的研究研讨会、统计培训和成像讲习班、职业发展和赠款撰写讲习班，作为哈佛新资助的CTSA的一部分，以及在布里格姆妇女医院、麻省总医院、麻省理工学院和哈佛公共卫生学院的教学课程工作。候选人本人将获得与她正在进行的研究相关的先进统计和流行病学方法方面的更多专业知识，并将扩大她对静息功能连接技术的研究，作为K24奖建议的新研究的一部分。K24将有助于推进候选人在早期AD神经成像方面的研究生涯，并保护她指导致力于AD患者研究的新一代调查人员的时间。 公共卫生相关性：申请者的研究计划寻求了解老年人记忆问题的原因，开发成像工具来检测阿尔茨海默病(AD)的最早迹象，并使用这些成像工具来寻找治疗AD的有效方法。申请者将利用K24奖来扩大她的成像研究计划，并为面向患者的AD研究的临床研究职业培训新的研究人员。