Core A: Administrative Core

核心A：行政核心

• 批准号: 10541799
• 负责人: REISA A. SPERLING
• 金额: $ 27.1万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10541799
• 关键词: Administrator; Aging; Agreement; Alzheimer' s Disease; Amyloid; Annual Reports; Authorization documentation; Autopsy; Biological Markers; Budgets; Clinical; Clinical Data; Clinical Trials; Cohort Studies; Collaborations; Communication; Communities; Data; Documentation; Ensure; Expenditure; Funding; Future; General Hospitals; Goals; Human; Human Resources; Image; Impaired cognition; Institution; Institutional Review Boards; International; Knowledge; Leadership; Manuscripts; Massachusetts; Monitor; Paper; Participant; Pathology; Persons; Plasma; Positron-Emission Tomography; Preparation; Prevention trial; Principal Investigator; Procedures; Productivity; Program Research Project Grants; Progress Reports; Publications; Radiation; Radiopharmaceuticals; Remunerations; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Safety; Sampling; Travel; United States National Institutes of Health; Work; aging brain; authority; biomedical imaging; data access; data exchange; data integrity; data quality; data sharing; design; improved; meetings; multidisciplinary; neuropathology; normal aging; organizational structure; posters; pre-clinical; programs; quality assurance; research study; tau Proteins; tool

SUMMARY: CORE A- ADMINISTRATIVE CORE. The Administrative (Admin) Core will provide the leadership, coordination, and administrative oversight to achieve the programmatic goals of the Harvard Aging Brain Study (HABS) Program Project Grant (PPG). The Admin Core will strive to ensure optimal integration of the five Cores and four research Projects of the HABS PPG renewal to achieve maximal scientific productivity. Aim 1: The Admin Core is led by the Co-Principal Investigators (Sperling/Johnson) and will provide administrative and scientific oversight of the PPG. The Admin Core, through the co-PIs of the PPG, will take primary responsibility for ensuring scientific rigor and reproducibility across all aspects of the HABS PPG. The Core will coordinate quarterly meetings of the Executive Committee and will convene in-person meetings of the External Scientific Advisory Board (ESAB). Aim 2: The Admin Core will facilitate the efficient communication and integration between all components of the PPG, provide oversight of timely data transfer from all Cores and Projects to the Analytic Core to achieve maximal scientific productivity, and track all scientific presentations and publications. Aim 3: The Admin Core will prepare NIH progress reports, interface with the Clinical Core to prepare IRB documentation and annual continuing review, and with the Imaging Core to prepare annual reports to the MGH Radioactive Drug Research Committee. Aim 4: The Admin Core will oversee all aspects of the PPG finances to assure fiscal responsibility. Aim 5: The Admin Core will serve to coordinate PPG interactions with institutional resources and programs, including the Massachusetts Alzheimer’s Disease Research Center (MADRC), the Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH), and the MGH PET Core. Aim 6: The Admin Core will serve to facilitate collaborations between the PPG and related scientific initiatives within Harvard and the larger scientific community, providing oversight of the rapidly increasing number of requests for collaborations and data sharing. The Admin Core seeks to enhance the coordination of an outstanding multidisciplinary group of investigators with a strong record of collaboration and scientific productivity. The Admin Core will serve to maximize the knowledge gained from the rich longitudinal data from the well-characterized HABS cohort to improve our understanding of the gradual transition from normal aging to the earliest stages of preclinical Alzheimer’s disease (AD), and inform the design and analytic strategies for ongoing and future prevention trials. Given the multitude of recent disappointing results from clinical trials in the symptomatic stages of Alzheimer’s disease (AD), our continued work to elucidate the impact of amyloid and tau pathology on the aging brain, and new research initiatives to better understand the many factors that modulate cognitive decline, are more important than ever.

摘要：核心A-行政核心。行政（管理）核心将提供领导 协调和行政监督，以实现哈佛大学衰老大脑研究的程序化目标 （HABS）计划项目赠款（PPG）。管理员核心将努力确保五个 HABS PPG更新的核心和四个研究项目，以实现最大的科学产品。目标1： 管理员核心由联合主持调查员（Sperling/Johnson）领导，将提供行政和 PPG的科学监督。通过PPG的共同核心，管理员核心将承担主要责任 为了确保HABSPG的各个方面的科学严谨性和可重复性。核心将协调 执行委员会的季度会议，并将方便外部科学会议 顾问委员会（ESAB）。目标2：管理员核心将支持有效的沟通和集成 在PPG的所有组件之间，对所有核心和项目的及时数据传输到 分析核心，以实现最大的科学产品，并跟踪所有科学演示和 出版物。 AIM 3：管理员核心将准备NIH进度报告，与临床核心接口到 准备IRB文档和年度持续审查，并使用成像核心准备年度 向MGH放射性药物研究委员会报告。目标4：管理员核心将监督 PPG财务保证财政责任。 AIM 5：管理员核心将用于协调PPG 与机构资源和计划的互动，包括马萨诸塞州阿尔茨海默氏病 马萨诸塞州综合医院的马提尼斯生物医学成像中心研究中心（MADRC） （MGH）和MGH宠物核心。目标6：管理员核心将有助于促进 PPG及其相关科学计划和更大的科学界，提供监督 对协作和数据共享的请求数量迅速增加。管理员核心试图 增强出色的多学科研究人员的协调，并有很强的记录 协作和科学生产力。管理员核心将有助于最大化 来自特征良好的HABS队列的丰富纵向数据，以提高我们对等级的理解 从正常衰老到临床前阿尔茨海默氏病（AD）的最早阶段的过渡，并告知 持续预防试验的设计和分析策略。考虑到最近的众多 在阿尔茨海默氏病（AD）症状阶段进行临床试验的令人失望的结果，我们继续 努力阐明淀粉样蛋白和TAU病理对衰老大脑的影响，以及新的研究计划 更好地了解调节认知能力下降的许多因素比以往任何时候都更为重要。