Core A: Administrative Core

摘要：核心A--行政核心。行政(行政)核心将提供领导， 协调和行政监督，以实现哈佛老龄化大脑研究的规划目标 (HABS)计划项目赠款(PPG)。管理核心将努力确保五个方面的最佳整合 哈布斯PPG更新的核心和四个研究项目，以实现最大的科学生产力。目标1： 行政核心由联合首席调查员(斯珀林/约翰逊)领导，将提供行政和 对PPG的科学监督。行政核心，通过PPG的共同绩效指标，将承担主要责任 确保HABS PPG所有方面的科学严谨性和可重复性。核心将协调 执行委员会的季度会议，并将召开外部科学委员会的面对面会议 咨询委员会(伊萨)。目标2：管理核心将促进高效的沟通和整合 在PPG的所有组成部分之间提供监督，及时从所有核心和项目向 分析核心，以实现最大的科学生产力，并跟踪所有科学演示和 出版物。目标3：管理核心将准备NIH进度报告，与临床核心接口以 准备IRB文件和年度持续审查，并与成像核心一起准备年度 向MGH放射性药物研究委员会提交的报告。目标4：管理核心将监督以下各方面 PPG为财政提供资金，以确保财政责任。目标5：管理核心将负责协调PPG 与机构资源和方案的互动，包括马萨诸塞州阿尔茨海默病 马萨诸塞州总医院马蒂诺斯生物医学成像研究中心 (MGH)和MGH PET核心。目标6：管理核心将有助于促进 PPG和哈佛大学和更大的科学界内的相关科学倡议，提供对 关于协作和数据共享的请求数量迅速增加。管理核心寻求 加强协调一支出色的多学科调查小组，该小组有良好的 协作和科学生产力。管理核心将用于最大限度地利用从 丰富的纵向数据来自于特征良好的HAB队列，以提高我们对逐步 从正常衰老过渡到临床前阿尔茨海默病(AD)的早期阶段，并告知 为正在进行的和未来的预防试验设计和分析战略。鉴于最近发生的大量 阿尔茨海默病(AD)症状阶段的临床试验结果令人失望，我们继续 致力于阐明淀粉样蛋白和tau病理对老化大脑的影响，以及新的研究倡议 更好地理解调节认知能力下降的诸多因素，比以往任何时候都更加重要。

SUMMARY: CORE A- ADMINISTRATIVE CORE. The Administrative (Admin) Core will provide the leadership, coordination, and administrative oversight to achieve the programmatic goals of the Harvard Aging Brain Study (HABS) Program Project Grant (PPG). The Admin Core will strive to ensure optimal integration of the five Cores and four research Projects of the HABS PPG renewal to achieve maximal scientific productivity. Aim 1: The Admin Core is led by the Co-Principal Investigators (Sperling/Johnson) and will provide administrative and scientific oversight of the PPG. The Admin Core, through the co-PIs of the PPG, will take primary responsibility for ensuring scientific rigor and reproducibility across all aspects of the HABS PPG. The Core will coordinate quarterly meetings of the Executive Committee and will convene in-person meetings of the External Scientific Advisory Board (ESAB). Aim 2: The Admin Core will facilitate the efficient communication and integration between all components of the PPG, provide oversight of timely data transfer from all Cores and Projects to the Analytic Core to achieve maximal scientific productivity, and track all scientific presentations and publications. Aim 3: The Admin Core will prepare NIH progress reports, interface with the Clinical Core to prepare IRB documentation and annual continuing review, and with the Imaging Core to prepare annual reports to the MGH Radioactive Drug Research Committee. Aim 4: The Admin Core will oversee all aspects of the PPG finances to assure fiscal responsibility. Aim 5: The Admin Core will serve to coordinate PPG interactions with institutional resources and programs, including the Massachusetts Alzheimer’s Disease Research Center (MADRC), the Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH), and the MGH PET Core. Aim 6: The Admin Core will serve to facilitate collaborations between the PPG and related scientific initiatives within Harvard and the larger scientific community, providing oversight of the rapidly increasing number of requests for collaborations and data sharing. The Admin Core seeks to enhance the coordination of an outstanding multidisciplinary group of investigators with a strong record of collaboration and scientific productivity. The Admin Core will serve to maximize the knowledge gained from the rich longitudinal data from the well-characterized HABS cohort to improve our understanding of the gradual transition from normal aging to the earliest stages of preclinical Alzheimer’s disease (AD), and inform the design and analytic strategies for ongoing and future prevention trials. Given the multitude of recent disappointing results from clinical trials in the symptomatic stages of Alzheimer’s disease (AD), our continued work to elucidate the impact of amyloid and tau pathology on the aging brain, and new research initiatives to better understand the many factors that modulate cognitive decline, are more important than ever.