Core F - Neuroimaging Core

核心 F - 神经影像核心

• 批准号: 8676355
• 负责人: REISA A. SPERLING
• 金额: $ 17.59万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8676355
• 关键词: Alzheimer' s Disease; Amyloid; Cataloging; Catalogs; Clinical; Clinical Data; Clinical Research; Collaborations; Data; Data Analyses; Diffusion; Disclosure; Foundations; Funding; Future; General Hospitals; Grant; Health Professional; Human; Image; Industry; Inflammation; Institutional Review Boards; Lead; Ligands; Magnetic Resonance Imaging; Massachusetts; Methods; Molecular; Multi-Institutional Clinical Trial; Participant; Pilot Projects; Play; Positron-Emission Tomography; Protocols documentation; Public Health; Research; Research Personnel; Research Project Grants; Resources; Role; Testing; Thick; Tracer; United States National Institutes of Health; Work; abstracting; amyloid imaging; bioimaging; career development; cohort; data acquisition; imaging modality; interest; neuroimaging; novel; outreach; research study; tau Proteins; tool

NEUROIMAGING CORE PROJECT SUMMARY/ABSTRACT The Neuroimaging Core is a newly proposed Core that will greatly enhance the imaging capabilities of the Massachusetts ADRC (MADRC). The Imaging Core will leverage MADRC investigator expertise in molecular, functional, and structural imaging and the state-of-the-art resources of the Martinos Center for Biomedical Imaging and the Massachusetts General Hospital PET Core to augment our Center's strengths in cutting edge, multi-modality imaging research. The Imaging Core will provide direct support for Project 1 (Hedden) and Project 2 (Gomez-Isla) through volumetric and functional connectivity MRI and PET amyloid imaging data acquisition and analyses. We will also continue to support the imaging components of other MADRC investigator led projects, including ongoing NIH funded PPG, R01s, K23, multiple foundation grants and future MADRC pilot grants. Working closely with the Clinical and Data Cores, the Imaging Core will support standardized acquisition protocols and catalogued storage of neuroimaging data collected on subjects in the MADRC Longitudinal Cohort participating in MADRC affiliated imaging research projects. We will also acquire MRI (3T) and PET amyloid imaging on a small number of LC subjects of special interest to our center and will provide these data to Projects 1 and 2, as well as to other MADRC affiliated studies with appropriate IRB approval. We will facilitate the implementation of new PET tracers, currently being tested in affiliated projects, including recently developed PET ligands for tau, inflammation, and mGluR5 into MADRC affiliated research studies. Similarly, we will facilitate the implementation of novel MRI methods and analytic tools, such as functional connectivity, the connectome scanner, and cortical thickness signatures into new and ongoing MADRC projects. The Imaging Core will further enhance MADRC's active involvement in national multi-center projects with major neuroimaging components, including ADNI, DIAN, NIFD, NIH and industry sponsored multi-center clinical trials, including the upcoming ADCS Anti-Amyloid Treatment in Asymptomatic AD (A4) trial. We will work closely with the Outreach Core to lead national efforts to educate the public and health care professionals about the appropriate clinical use of PET amyloid imaging and with the ADCS and collaborating ADRCs on important issues related to disclosure of amyloid status to research participants. We will provide expertise on multi-modality image acquisition and analysis to young investigators interested in incorporating neuroimaging into pilot projects and career development proposals. Neuroimaging is likely to play an even more integral role in AD clinical research over the next 5 years. This new Imaging Core will work closely with the existing MADRC cores, substantially augment our ability to provide frontline support to MADRC affiliated imaging studies, including two of the research projects proposed for the renewal, and will facilitate new collaborations both within our Center and with other ADCs.

神经影像核心项目摘要/摘要 Neuroimaging Core是一个新提出的Core，它将大大增强神经成像能力 马萨诸塞州 ADRC (MADRC)。成像核心将利用 MADRC 研究人员在分子、 马蒂诺斯生物医学中心的功能和结构成像以及最先进的资源 影像学和麻省总医院 PET 核心增强了我们中心在尖端、 多模态成像研究。成像核心将为项目 1（Hedden）和 项目 2 (Gomez-Isla) 通过体积和功能连接 MRI 和 PET 淀粉样蛋白成像数据 采集和分析。我们还将继续支持其他 MADRC 的成像组件 研究者领导的项目，包括正在进行的 NIH 资助的 PPG、R01s、K23、多项基金会拨款和未来 MADRC 试点补助金。成像核心与临床和数据核心密切合作，将支持 对受试者收集的神经影像数据进行标准化采集协议和编目存储 MADRC 纵向队列参与 MADRC 附属成像研究项目。我们还将收购 对我们中心特别感兴趣的少数 LC 受试者进行 MRI (3T) 和 PET 淀粉样蛋白成像，并将 将这些数据提供给项目 1 和 2，以及其他 MADRC 附属研究以及适当的 IRB 赞同。我们将促进新型 PET 示踪剂的实施，目前正在附属项目中进行测试， 将最近开发的 tau、炎症和 mGluR5 PET 配体纳入 MADRC 附属研究 研究。同样，我们将促进新型 MRI 方法和分析工具的实施，例如 功能连接、连接组扫描仪和皮质厚度特征成为新的和正在进行的 MADRC 项目。成像核心将进一步增强 MADRC 积极参与国家多中心的工作 具有主要神经影像组件的项目，包括 ADNI、DIAN、NIFD、NIH 和行业赞助 多中心临床试验，包括即将进行的 ADCS 抗淀粉样蛋白治疗无症状 AD (A4) 试验。 我们将与外展核心密切合作，领导全国公众教育和医疗保健工作 专业人士了解 PET 淀粉样蛋白成像的适当临床应用以及 ADCS 和合作 ADRC 讨论与向研究参与者披露淀粉样蛋白状态相关的重要问题。我们将提供 向有兴趣整合的年轻研究人员提供多模态图像采集和分析方面的专业知识 神经影像学纳入试点项目和职业发展建议。神经影像学可能会发挥更大的作用 未来 5 年 AD 临床研究中不可或缺的作用。这个新的成像核心将与 现有的 MADRC 核心，大大增强了我们为 MADRC 附属机构提供一线支持的能力 成像研究，包括拟议更新的两个研究项目，并将促进新的研究 我们中心内部以及与其他 ADC 的合作。