Core F - Neuroimaging Core

核心 F - 神经影像核心

• 批准号: 8676355
• 负责人: REISA A. SPERLING
• 金额: $ 17.59万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8676355
• 关键词: Alzheimer' s Disease; Amyloid; Cataloging; Catalogs; Clinical; Clinical Data; Clinical Research; Collaborations; Data; Data Analyses; Diffusion; Disclosure; Foundations; Funding; Future; General Hospitals; Grant; Health Professional; Human; Image; Industry; Inflammation; Institutional Review Boards; Lead; Ligands; Magnetic Resonance Imaging; Massachusetts; Methods; Molecular; Multi-Institutional Clinical Trial; Participant; Pilot Projects; Play; Positron-Emission Tomography; Protocols documentation; Public Health; Research; Research Personnel; Research Project Grants; Resources; Role; Testing; Thick; Tracer; United States National Institutes of Health; Work; abstracting; amyloid imaging; bioimaging; career development; cohort; data acquisition; imaging modality; interest; neuroimaging; novel; outreach; research study; tau Proteins; tool

NEUROIMAGING CORE PROJECT SUMMARY/ABSTRACT The Neuroimaging Core is a newly proposed Core that will greatly enhance the imaging capabilities of the Massachusetts ADRC (MADRC). The Imaging Core will leverage MADRC investigator expertise in molecular, functional, and structural imaging and the state-of-the-art resources of the Martinos Center for Biomedical Imaging and the Massachusetts General Hospital PET Core to augment our Center's strengths in cutting edge, multi-modality imaging research. The Imaging Core will provide direct support for Project 1 (Hedden) and Project 2 (Gomez-Isla) through volumetric and functional connectivity MRI and PET amyloid imaging data acquisition and analyses. We will also continue to support the imaging components of other MADRC investigator led projects, including ongoing NIH funded PPG, R01s, K23, multiple foundation grants and future MADRC pilot grants. Working closely with the Clinical and Data Cores, the Imaging Core will support standardized acquisition protocols and catalogued storage of neuroimaging data collected on subjects in the MADRC Longitudinal Cohort participating in MADRC affiliated imaging research projects. We will also acquire MRI (3T) and PET amyloid imaging on a small number of LC subjects of special interest to our center and will provide these data to Projects 1 and 2, as well as to other MADRC affiliated studies with appropriate IRB approval. We will facilitate the implementation of new PET tracers, currently being tested in affiliated projects, including recently developed PET ligands for tau, inflammation, and mGluR5 into MADRC affiliated research studies. Similarly, we will facilitate the implementation of novel MRI methods and analytic tools, such as functional connectivity, the connectome scanner, and cortical thickness signatures into new and ongoing MADRC projects. The Imaging Core will further enhance MADRC's active involvement in national multi-center projects with major neuroimaging components, including ADNI, DIAN, NIFD, NIH and industry sponsored multi-center clinical trials, including the upcoming ADCS Anti-Amyloid Treatment in Asymptomatic AD (A4) trial. We will work closely with the Outreach Core to lead national efforts to educate the public and health care professionals about the appropriate clinical use of PET amyloid imaging and with the ADCS and collaborating ADRCs on important issues related to disclosure of amyloid status to research participants. We will provide expertise on multi-modality image acquisition and analysis to young investigators interested in incorporating neuroimaging into pilot projects and career development proposals. Neuroimaging is likely to play an even more integral role in AD clinical research over the next 5 years. This new Imaging Core will work closely with the existing MADRC cores, substantially augment our ability to provide frontline support to MADRC affiliated imaging studies, including two of the research projects proposed for the renewal, and will facilitate new collaborations both within our Center and with other ADCs.

神经成像核心项目总结/摘要 神经成像核心是一个新提出的核心，将大大提高成像能力的 马萨诸塞州ADRC（MADRC）。成像核心将利用MADRC研究人员在分子， 功能和结构成像以及Martinos生物医学中心最先进的资源 成像和马萨诸塞州总医院PET核心，以加强我们中心的优势，在尖端， 多模态成像研究。成像核心将为项目1（Hedden）提供直接支持， 项目2（Gomez-Isla）通过体积和功能连接MRI和PET淀粉样蛋白成像数据 采集和分析。我们还将继续支持其他MADRC的成像组件 研究者领导的项目，包括正在进行的NIH资助的PPG，R 01 s，K23，多个基金会赠款和未来 MADRC试点赠款。与临床和数据核心密切合作，成像核心将支持 标准化的采集协议和分类存储的神经成像数据收集的主题， 参与MADRC附属成像研究项目的MADRC纵向队列。我们还将收购 我们中心特别关注的少数LC受试者的MRI（3 T）和PET淀粉样蛋白成像， 将这些数据提供给项目1和项目2，以及其他MADRC附属研究，并提供给适当的IRB 批准我们将促进实施新的PET示踪剂，目前正在附属项目中进行测试， 包括最近开发的tau、炎症和mGluR 5的PET配体，纳入MADRC附属研究 问题研究同样，我们将促进新的MRI方法和分析工具的实施，如 功能连接，连接体扫描仪，和皮质厚度签名到新的和正在进行的 MADRC项目。Imaging Core将进一步加强MADRC在国家多中心的积极参与 主要神经成像组件的项目，包括ADNI、DIAN、NIFD、NIH和行业赞助的项目 多中心临床试验，包括即将进行的ADCS抗淀粉样蛋白治疗无症状AD（A4）试验。 我们将与外联核心密切合作，领导全国教育公众和医疗保健的努力 专业人士关于PET淀粉样蛋白成像的适当临床使用，并与ADCS和合作 关于向研究参与者披露淀粉样蛋白状态的重要问题的ADRC。我们将提供 多模态图像采集和分析的专业知识，以年轻的研究人员有兴趣纳入 神经成像到试点项目和职业发展建议。神经影像学可能会发挥更大的作用， 在未来5年的AD临床研究中发挥重要作用。这个新的成像核心将与 现有的MADRC核心，大大增强了我们为MADRC附属机构提供前线支持的能力， 成像研究，包括两个研究项目提出的更新，并将促进新的 在我们的中心和与其他ADC的合作。