Core F - Neuroimaging Core

核心 F - 神经影像核心

• 批准号: 8676355
• 负责人: REISA A. SPERLING
• 金额: $ 17.59万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8676355
• 关键词: Alzheimer' s Disease; Amyloid; Cataloging; Catalogs; Clinical; Clinical Data; Clinical Research; Collaborations; Data; Data Analyses; Diffusion; Disclosure; Foundations; Funding; Future; General Hospitals; Grant; Health Professional; Human; Image; Industry; Inflammation; Institutional Review Boards; Lead; Ligands; Magnetic Resonance Imaging; Massachusetts; Methods; Molecular; Multi-Institutional Clinical Trial; Participant; Pilot Projects; Play; Positron-Emission Tomography; Protocols documentation; Public Health; Research; Research Personnel; Research Project Grants; Resources; Role; Testing; Thick; Tracer; United States National Institutes of Health; Work; abstracting; amyloid imaging; bioimaging; career development; cohort; data acquisition; imaging modality; interest; neuroimaging; novel; outreach; research study; tau Proteins; tool

NEUROIMAGING CORE PROJECT SUMMARY/ABSTRACT The Neuroimaging Core is a newly proposed Core that will greatly enhance the imaging capabilities of the Massachusetts ADRC (MADRC). The Imaging Core will leverage MADRC investigator expertise in molecular, functional, and structural imaging and the state-of-the-art resources of the Martinos Center for Biomedical Imaging and the Massachusetts General Hospital PET Core to augment our Center's strengths in cutting edge, multi-modality imaging research. The Imaging Core will provide direct support for Project 1 (Hedden) and Project 2 (Gomez-Isla) through volumetric and functional connectivity MRI and PET amyloid imaging data acquisition and analyses. We will also continue to support the imaging components of other MADRC investigator led projects, including ongoing NIH funded PPG, R01s, K23, multiple foundation grants and future MADRC pilot grants. Working closely with the Clinical and Data Cores, the Imaging Core will support standardized acquisition protocols and catalogued storage of neuroimaging data collected on subjects in the MADRC Longitudinal Cohort participating in MADRC affiliated imaging research projects. We will also acquire MRI (3T) and PET amyloid imaging on a small number of LC subjects of special interest to our center and will provide these data to Projects 1 and 2, as well as to other MADRC affiliated studies with appropriate IRB approval. We will facilitate the implementation of new PET tracers, currently being tested in affiliated projects, including recently developed PET ligands for tau, inflammation, and mGluR5 into MADRC affiliated research studies. Similarly, we will facilitate the implementation of novel MRI methods and analytic tools, such as functional connectivity, the connectome scanner, and cortical thickness signatures into new and ongoing MADRC projects. The Imaging Core will further enhance MADRC's active involvement in national multi-center projects with major neuroimaging components, including ADNI, DIAN, NIFD, NIH and industry sponsored multi-center clinical trials, including the upcoming ADCS Anti-Amyloid Treatment in Asymptomatic AD (A4) trial. We will work closely with the Outreach Core to lead national efforts to educate the public and health care professionals about the appropriate clinical use of PET amyloid imaging and with the ADCS and collaborating ADRCs on important issues related to disclosure of amyloid status to research participants. We will provide expertise on multi-modality image acquisition and analysis to young investigators interested in incorporating neuroimaging into pilot projects and career development proposals. Neuroimaging is likely to play an even more integral role in AD clinical research over the next 5 years. This new Imaging Core will work closely with the existing MADRC cores, substantially augment our ability to provide frontline support to MADRC affiliated imaging studies, including two of the research projects proposed for the renewal, and will facilitate new collaborations both within our Center and with other ADCs.

神经影像学核心项目摘要/摘要 神经影像学核心是一个新提出的核心，它将极大地增强成像能力 马萨诸塞州ADRC（MADRC）。成像核心将利用MADRC研究者的分子专业知识， 马提尼斯生物医学中心的功能性和结构成像以及最先进的资源 成像和马萨诸塞州综合医院宠物核心，以增强我们中心在最前沿的优势， 多模式成像研究。成像核心将为项目1（Hedden）和 通过体积和功能连通性MRI和PET淀粉样蛋白成像数据，项目2（Gomez-Isla） 获取和分析。我们还将继续支持其他MADRC的成像组件 研究者领导的项目，包括正在进行的NIH资助PPG，R01，K23，多个基金会赠款和未来 MADRC飞行员赠款。与临床和数据核紧密合作，成像核心将支持 标准化的采集方案和对受试者收集的神经影像数据的存储的分类 Madrc纵向队列参加了MADRC附属成像研究项目。我们也将获得 MRI（3T）和PET淀粉样蛋白成像对我们中心特别感兴趣的少数LC主体，并将 将这些数据提供给项目1和2的其他MADRC附属研究，并提供适当的IRB 赞同。我们将促进实施新的宠物示踪剂，目前正在附属项目中进行测试， 包括最近开发用于tau，炎症和mglur5的宠物配体进入MADRC附属研究 研究。同样，我们将促进实施新颖的MRI方法和分析工具，例如 功能连接性，连接组扫描仪和皮质厚度签名为新的和正在进行的 MADRC项目。成像核心将进一步增强MADRC的积极参与国家多中心 具有主要神经影像成分的项目，包括ADNI，DIAN，NIFD，NIH和行业赞助的项目 多中心临床试验，包括无症状AD（A4）试验中即将进行的ADC抗淀粉样蛋白治疗。 我们将与外展核心紧密合作，以领导国家努力教育公众和医疗保健 专业人士涉及适当使用PET淀粉样蛋白成像以及与ADC和合作的临床使用 关于与研究参与者披露淀粉样蛋白状况有关的重要问题的ADRC。我们将提供 对有兴趣合并的年轻调查人员的多模式图像获取和分析的专业知识 神经影像参与试点项目和职业发展建议。神经影像可能会发挥更多作用 在接下来的5年中，在AD临床研究中的积分作用不可或缺。这个新成像核心将与 现有的Madrc核心，大大增强了我们为马德克附属的一线支持的能力 成像研究，包括为续签提议的两个研究项目，并将促进新的 在我们中心和其他ADC中的合作。