Gordon Research Conference on Autophagy series

摘要： 这项提议要求部分支持将于2010年4月25日至30日在意大利Il Ciocco以及2012年和2014年在待定地点举行的关于自噬的戈登研究会议(GRC)系列会议(3次会议)。自噬是影响正常衰老和人类多种主要疾病的一种基本的细胞内平衡机制。这些疾病作为独立的实体意义重大，但与衰老有关：癌症、神经退行性变、炎症、肌肉和免疫疾病以及代谢紊乱。这个GRC系列的广泛和长期的目标是促进一种综合的方法来定义自噬在人类衰老和疾病的生理和病理过程中迅速扩大的作用。自噬GRC系列将有助于阐明自噬途径，以及自噬如何与正常的细胞生存和死亡途径或其异常有关。这些会议的具体目标将是召集代表自噬研究关键领域的40位演讲者和讨论领袖，总共有120多名与会者参加三次(2010年、2012年和2014年)为期五天的会议。2010年的计划将以一次主旨演讲和八次会议为特色，广泛讨论自噬调控、自噬信号、自噬机制、自噬的起源、选择性自噬以及自噬在代谢性疾病和癌症、先天和适应性免疫、衰老和神经学中的作用等当前问题。此外，两个晚上的海报会议将允许所有参与者为这些主题做出贡献。2012年和2014年，类似的计划将涵盖自噬的基本方面，并继续并更加重视自噬在衰老、神经退行性疾病、肌病、代谢性疾病、癌症和免疫学(包括感染、炎症和自身免疫)中的作用。这一应用的意义在于，自噬GRC已经成为每年一系列会议的中心议题，这些会议对自噬学者的国际社会的研究产生了重要影响、指导和推动作用。这些会议聚集了自噬领域最前沿的研究人员，并为初级科学家和研究生提供机会，以海报形式展示他们的工作，并与该领域的领导者交流思想，从而培养下一代自噬研究领导者。这一应用与健康相关的是，自噬直接影响人类的一系列健康和疾病状态，包括衰老、神经退化、癌症、代谢紊乱、肌肉退化、免疫功能和炎症性疾病。由GRC关于自噬的会议推动的研究将有助于更好地了解正常的衰老过程；有助于开发治疗神经变性、肌肉萎缩、癌症、代谢性疾病、感染、慢性炎症和免疫紊乱的新方法。

Abstract: This proposal requests partial support for the Gordon Research Conference (GRC) series on Autophagy (3 conferences) to be held in Il Ciocco, Italy April 25-30, 2010, and in 2012 and 2014 at yet to be determined sites. Autophagy is a fundamental cellular homeostatic mechanism affecting normal aging and a wide spectrum of major human disease categories. These diseases are significant as standalone entities while being associated with aging: cancer, neurodegeneration, inflammation, muscle and immune diseases, and metabolic disorders. The broad and long term goal of this GRC series is to promote an integrated approach in defining the rapidly expanding role of autophagy in physiological and pathological processes that underlie human aging and diseases. The Autophagy GRC series will facilitate elucidation of the autophagy pathway and how autophagy pertains to normal cell survival and death pathways or their anomalies. The specific aims of these meetings will be to convene 40 speakers and discussion leaders that represent critical areas of autophagy research with a total of over 120 participants for three (2010, 2012, and 2014) five day conferences. The program in 2010 will feature a keynote address and eight sessions that broadly address current issues in regulation of autophagy, autophagy signaling, autophagy machinery, origin of the autophagosome, selective autophagy, and roles of autophagy in metabolic diseases and cancer, innate and adaptive immunity, aging and neurology. In addition, two evening poster sessions will permit all participants to contribute to these topics. In 2012 and 2014, similar programs will cover fundamental aspects of autophagy and place continued and increased emphasis on its role in aging, neurodegeneration, myopathies, metabolic disease, cancer, and immunology including infection, inflammation and autoimmunity. The significance of this application is that the Autophagy GRCs have become the centerpiece of the yearly series of conferences that critically influence, direct and propel research in the international community of autophagy scholars. These conferences bring together investigators who are at the forefront of the autophagy field, and provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field thus nurturing the next generation of autophagy research leaders. The health relatedness of this application is that autophagy directly impacts a wide spectrum of human health and disease states including aging, neurodegeneration, cancer, metabolic disorders, myodegeneration, immune functions and inflammatory diseases. The research spurred by GRC meetings on autophagy will lead to a greater understanding of normal aging processes; help to develop new approaches in treatments of neurodegeneration, muscle atrophy, cancer, metabolic diseases, infection, chronic inflammation and immune disorders.