AIM Administrative Core

AIM 管理核心

• 批准号: 10249117
• 负责人: VOJO P DERETIC
• 金额: $ 70.63万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10249117
• 关键词: Achievement; Aging; Alzheimer' s Disease; Area; Atherosclerosis; Autoimmune Diseases; Autoimmunity; Autophagocytosis; Award; Cells; Center for Translational Science Activities; Centers of Research Excellence; Clinical Sciences; Communities; Dangerousness; Development; Development Plans; Diabetes Mellitus; Discipline; Disease; Educational workshop; Elements; Ensure; Event; Feedback; Fostering; Foundations; Funding; Goals; Health; Health Sciences; Heart Diseases; Home; Human; Individual; Infection; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Infrastructure; Institution; International; Laboratories; Leadership; Link; Malignant Neoplasms; Measures; Medical; Mentors; Metabolic; Metabolism; Modality; Monitor; New Mexico; Obesity; Performance; Periodicity; Physiological Processes; Population; Principal Investigator; Process; Recommendation; Recording of previous events; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Role; Science; Scientist; Surveys; System; Training; United States National Institutes of Health; Universities; Work; base; career; career development; cohesion; experience; innovation; lens; novel; operation; programs; research and development; skills; success; symposium; tool

SUMMARY Autophagy is a rapidly developing field. It has translational potential in inflammatory bowel disease, autoimmunity, classical and emerging infections, obesity, diabetes, atherosclerosis and heart disease, cancer, Alzheimer's disease, and aging. The proposed interdisciplinary Autophagy, Inflammation, and Metabolism (AIM) Center will explore physiological processes and disease states through the lens of autophagy. AIM seeks to enable mentored principal investigators (mPIs) to achieve funding independence and pursue innovative and competitive research. AIM's unique theme links autophagy with inflammation and metabolism in different health and disease states. Autophagy studies require technological infrastructure, expert investigators, organized mentoring, vigorous exchange of scientific ideas, and administrative support. An effective Administrative Core (AC) will establish requisites, provide administrative leadership, ensure mentoring excellence, and foster technological and scientific cohesiveness. Specific Aim 1. Provide scientific leadership and direction for the AIM Center along with research, administrative, and fiscal support plus a physical home. AIM leadership, with Internal and External Advisory boards, will establish, maintain, and develop the Center's scientific direction. AC will interface with other CoBRE and IDeA centers. In its newly renovated physical home, AIM will house a conference room, space for scientific cores, small administrative office, and open laboratory space for activities and technical workshops. Specific Aim 2. Coordinate research infrastructure, mentoring, and evaluative efforts; career development for mentored PIs; and success of the Center. AC will direct and integrate AIM center activities, and mentor and train junior investigators, through Individual Development Plans. Assessments will monitor progress toward R01 funding. AC will organize, deliver, and evaluate mentoring skills for mentors and research and professional skills for mentees. Seminars, periodic technical workshops, surveys, and reports will provide feedback on mPI research, scientific cores performance, and overall AIM Center progress. Activities will be assessed by evaluative strategies and recommendations implemented. Specific Aim 3. Develop and support a growing community of AIM investigators and increase impact of the Center upon the state and regional scientific enterprise and infrastructure. Collaborative research, shared facilities and resources, seminars, workshops, and conferences are key to developing a functioning community of investigators working on scientific problems aligned with the AIM thematic areas. AC will serve as the anchor for AIM related scientific community activities, and coordinate interactions with UNM HSC campus investigators, all UNM HSC Signature Programs, Clinical and Translational Science Center, the existing New Mexico IDeA Centers, and the wider regional and national audience and entities.

总结 自噬是一个发展迅速的领域。它在炎症性肠病中具有转化潜力， 自身免疫，经典和新兴感染，肥胖，糖尿病，动脉粥样硬化和心脏病，癌症， 老年痴呆症和衰老。提出的跨学科自噬，炎症和代谢 (AIM)中心将通过自噬的透镜探索生理过程和疾病状态。目的 旨在使受指导的主要调查员（mPI）实现资金独立， 创新和有竞争力的研究。AIM的独特主题将自噬与炎症和代谢联系在一起， 不同的健康和疾病状态。自噬研究需要技术基础设施，专家 研究人员，有组织的指导，积极的科学思想交流和行政支持。一个 一个有效的行政核心（AC）将建立一个协调机制，提供行政领导，确保指导 卓越，促进科技凝聚力。 具体目标1。沿着研究，为AIM中心提供科学领导和方向， 行政和财政支持，加上一个实体的家。AIM领导层，内部和外部 咨询委员会，将建立，维护和发展中心的科学方向。AC将与 其他CoBRE和IDEA中心。在其新装修的物理家，AIM将容纳一个会议室，空间 用于科学核心、小型行政办公室和用于活动和技术研讨会的开放式实验室空间。 具体目标2。协调研究基础设施，指导和评估工作;职业生涯 受指导的PI的发展;以及中心的成功。AC将指导和整合AIM中心 活动，并通过个人发展计划指导和培训初级调查员。评估将 监督R 01供资的进展。AC将为导师组织、提供和评估辅导技能， 为学员提供研究和专业技能。研讨会、定期技术讲习班、调查和报告将 提供有关mPI研究、科学核心性能和AIM中心整体进展的反馈。活动 将通过已执行的评价战略和建议进行评估。 具体目标3。发展和支持不断壮大的AIM研究者社区， 该中心对国家和区域科学企业和基础设施的影响。协同 研究、共享设施和资源、研讨会、讲习班和会议是发展一个 致力于研究与AIM主题领域相一致的科学问题的研究人员的运作社区。AC 将作为AIM相关科学社群活动的锚，并协调与UNM的互动 HSC校园研究人员，所有UNM HSC签名计划，临床和转化科学中心， 现有的新墨西哥州IDEA中心，以及更广泛的区域和国家受众和实体。