AIM Administrative Core

摘要 自噬是一个快速发展的领域。它在炎症性肠病中具有转化潜力， 自身免疫、经典和新发感染、肥胖、糖尿病、动脉粥样硬化和心脏病、癌症、 阿尔茨海默病和衰老。拟议的跨学科自噬、炎症和代谢 (AIM) 中心将通过自噬的视角探索生理过程和疾病状态。目的 寻求使受指导的主要研究者 (mPI) 实现资金独立并追求 创新和有竞争力的研究。 AIM 的独特主题将自噬与炎症和代谢联系起来 不同的健康和疾病状态。自噬研究需要技术基础设施、专家 调查人员、有组织的指导、积极的科学思想交流和行政支持。安 有效的行政核心（AC）将确定必要条件，提供行政领导，确保指导 卓越，并培养技术和科学凝聚力。 具体目标 1. 为 AIM 中心提供科学领导和指导以及研究、 行政和财政支持以及实体住宅。 AIM 领导力，包括内部和外部 顾问委员会将建立、维护和发展该中心的科学方向。 AC 将与 其他 CoBRE 和 IDeA 中心。 AIM 在其新装修的实体住宅中将设有会议室、空间 用于科学核心、小型行政办公室以及用于活动和技术研讨会的开放实验室空间。 具体目标 2. 协调研究基础设施、指导和评估工作；职业生涯 指导 PI 的开发；以及中心的成功。 AC 将指导并整合 AIM 中心 活动，并通过个人发展计划指导和培训初级调查员。评估将 监控 R01 资金的进展。 AC 将组织、提供和评估导师的指导技能和 受训者的研究和专业技能。研讨会、定期技术研讨会、调查和报告将 提供有关 mPI 研究、科学核心性能和 AIM 中心整体进展的反馈。活动 将通过实施的评价策略和建议进行评估。 具体目标 3. 发展和支持不断壮大的 AIM 研究人员社区，并增加 该中心对国家和地区科学企业和基础设施的影响。协作性 研究、共享设施和资源、研讨会、讲习班和会议是发展 致力于研究与 AIM 主题领域相关的科学问题的研究人员的职能社区。交流电 将作为 AIM 相关科学界活动的支柱，并协调与 UNM 的互动 HSC 校园研究人员、所有 UNM HSC 特色项目、临床和转化科学中心、 现有的新墨西哥 IDeA 中心，以及更广泛的地区和国家受众和实体。

SUMMARY Autophagy is a rapidly developing field. It has translational potential in inflammatory bowel disease, autoimmunity, classical and emerging infections, obesity, diabetes, atherosclerosis and heart disease, cancer, Alzheimer's disease, and aging. The proposed interdisciplinary Autophagy, Inflammation, and Metabolism (AIM) Center will explore physiological processes and disease states through the lens of autophagy. AIM seeks to enable mentored principal investigators (mPIs) to achieve funding independence and pursue innovative and competitive research. AIM's unique theme links autophagy with inflammation and metabolism in different health and disease states. Autophagy studies require technological infrastructure, expert investigators, organized mentoring, vigorous exchange of scientific ideas, and administrative support. An effective Administrative Core (AC) will establish requisites, provide administrative leadership, ensure mentoring excellence, and foster technological and scientific cohesiveness. Specific Aim 1. Provide scientific leadership and direction for the AIM Center along with research, administrative, and fiscal support plus a physical home. AIM leadership, with Internal and External Advisory boards, will establish, maintain, and develop the Center's scientific direction. AC will interface with other CoBRE and IDeA centers. In its newly renovated physical home, AIM will house a conference room, space for scientific cores, small administrative office, and open laboratory space for activities and technical workshops. Specific Aim 2. Coordinate research infrastructure, mentoring, and evaluative efforts; career development for mentored PIs; and success of the Center. AC will direct and integrate AIM center activities, and mentor and train junior investigators, through Individual Development Plans. Assessments will monitor progress toward R01 funding. AC will organize, deliver, and evaluate mentoring skills for mentors and research and professional skills for mentees. Seminars, periodic technical workshops, surveys, and reports will provide feedback on mPI research, scientific cores performance, and overall AIM Center progress. Activities will be assessed by evaluative strategies and recommendations implemented. Specific Aim 3. Develop and support a growing community of AIM investigators and increase impact of the Center upon the state and regional scientific enterprise and infrastructure. Collaborative research, shared facilities and resources, seminars, workshops, and conferences are key to developing a functioning community of investigators working on scientific problems aligned with the AIM thematic areas. AC will serve as the anchor for AIM related scientific community activities, and coordinate interactions with UNM HSC campus investigators, all UNM HSC Signature Programs, Clinical and Translational Science Center, the existing New Mexico IDeA Centers, and the wider regional and national audience and entities.