Autophagy, Inflammation and Metabolism (AIM) in Disease Center

摘要 自噬是所有健康人体内一个基本的动态平衡和代谢过程 细胞。自噬在饥饿或生长因子停用期间维持细胞新陈代谢需要，清除 通过去除受损的细胞器和有毒的蛋白质聚集体进入细胞内部，并使内源性或 外源性炎症促进剂。越来越多的研究表明，自噬广泛影响人类健康和 疾病包括炎症、代谢(糖尿病、肥胖)、感染、自身免疫、 癌症、神经退化和衰老。拟建的生物医学研究卓越中心(COBRE) 疾病中的自噬、炎症和代谢(AIM)将为被指导的患者提供生物医学方面的卓越服务 自噬及其与炎症和代谢过程相互作用的研究。新墨西哥州和 国家缺乏在这一新颖、不断发展的领域发展师资和连贯研究计划的计划 翻译含义。具有地区和国家影响的AIM将缩小这一差距。 新墨西哥大学健康科学中心(UNM HSC)聘用国内和国际领导人 在自噬加上初级研究人员探索炎症、新陈代谢和其他 具有自噬功能的过程。UNM HSC提供(I)机构支持，(Ii)未来教员招聘，(Iii)翻译 资源(临床和转化科学中心)，(Iv)教师指导，和(V)有效的基础设施，以 确保AIM成为全国卓越中心。反过来，AIM将提供最先进的设备、技术 专业知识、培训和指导，为多个新项目赢得R01资金。AIM将建立在 最初的调查人员和导师队列，招募新的调查人员，并开发一个可持续的中心，以 达到机构发展奖(IDEA)计划目标。 具体目标1.建立一个国家认可的AIM Cobre，开创自噬及其相关研究的先河 与炎症和新陈代谢有关，是疾病的基础。 具体目标2.在AIM的研究范围内发展足够多的调查人员，建立指导 基础设施，以促进初级教师的职业发展，并为调查人员提供指导支持 实现国家卫生研究院的独立资助。 具体目标3.建立科学核心，以使现在和未来的受指导个人以及 UNM HSC和新墨西哥州的科学界。 AIM将使科学资源在当地增长，补充现有设施而不重叠，开发 一支优秀的教师队伍，并在机构和全州范围内增加研究经费。AIM将与 新墨西哥州其他创意中心在不复制现有核心、设施和共享的情况下实现协同 UNM HSC和该区域的资源。

SUMMARY Autophagy is a fundamental homeostatic and metabolic intracellular process operational in all healthy human cells. Autophagy sustains cellular metabolic needs during starvation or growth factor withdrawal, cleanses the cell interior by removing damaged organelles and toxic protein aggregates, and rids cells of endogenous or exogenous promoters of inflammation. Increasingly studied, autophagy broadly affects human health and disease with disorders ranging from inflammatory, metabolic (diabetes, obesity), infection, autoimmune, cancer, neurodegeneration, and aging. The proposed Center of Biomedical Research Excellence (CoBRE) for Autophagy, Inflammation, and Metabolism (AIM) in Disease will serve biomedical excellence for mentored research on autophagy and its interactions with inflammatory and metabolic processes. Both New Mexico and the nation lack a program to develop faculty and coherent research programs in this novel, evolving area with translational implications. With regional and national implications, AIM will close that gap. University of New Mexico Health Sciences Center (UNM HSC) employs national and international leaders in autophagy plus junior investigators exploring the intersections of inflammation, metabolism, and other processes with autophagy. UNM HSC offers (i) institutional support, (ii) future faculty hires, (iii) translational resources (Clinical and Translational Science Center), (iv) faculty mentoring, and (v) effective infrastructure to secure AIM as a national center of excellence. In turn, AIM will provide state-of-the-art equipment, technical expertise, training, and mentoring to win R01 funding for multiple new projects. AIM will build on the strength of the initial cohort of investigators and mentors, recruit new investigators, and develop a sustainable center to meet Institutional Development Award (IDeA) program goals. Specific Aim 1. Establish a nationally recognized AIM CoBRE to pioneer the study of autophagy and its connections with inflammation and metabolism as a basis of disease. Specific Aim 2. Develop a critical mass of investigators within AIM's research scope, establish mentoring infrastructure to enable junior faculty career development, and provide mentoring support for investigators to achieve independent NIH funding. Specific Aim 3. Establish scientific cores to enable present and future cohorts of mentored PIs, as well as the scientific community at UNM HSC and New Mexico. AIM will enable local growth in scientific resources, complement existing facilities without overlaps, develop a cadre of excellent faculty, and increase research funding institutionally and statewide. AIM will interface with other New Mexico IDeA centers and synergize without duplicating existing cores, facilities, and shared resources at UNM HSC and the region.