Autophagy, Inflammation and Metabolism (AIM) in Disease Center

总结 自噬是一种基本的细胞内稳态和代谢过程，在所有健康的人中运作 细胞自噬在饥饿或生长因子撤除期间维持细胞代谢需要， 通过去除受损的细胞器和有毒蛋白质聚集体来去除细胞内部，并去除细胞中的内源性或 炎症的外源性促进剂。越来越多的研究表明，自噬广泛影响人类健康， 具有炎症、代谢（糖尿病、肥胖症）、感染、自身免疫 癌症、神经退化和衰老。生物医学研究卓越中心（CoBRE） 自噬，炎症和代谢（AIM）在疾病将服务于生物医学卓越的指导 研究自噬及其与炎症和代谢过程的相互作用。新墨西哥州和 国家缺乏一个计划，以发展教师和连贯的研究计划，在这个新的，不断发展的领域， 翻译的含义。AIM将缩小这一差距，具有区域和国家影响。 新墨西哥州健康科学中心（UNM HSC）的大学雇用国家和国际领导人 自噬加上初级研究人员探索炎症，代谢和其他 自噬的过程。UNM HSC提供（一）机构支持，（二）未来的教师招聘，（三）翻译 资源（临床和转化科学中心），（iv）教师指导，以及（v）有效的基础设施， 确保AIM成为国家卓越中心。反过来，AIM将提供最先进的设备，技术 专业知识、培训和指导，为多个新项目赢得R01资金。AIM将建立在以下优势之上： 最初的研究人员和导师队伍，招募新的研究人员，并建立一个可持续的中心， 达到机构发展奖（IDEA）计划的目标。 具体目标1。建立国家认可的AIM CoBRE，开创自噬及其相关研究的先河。 与炎症和新陈代谢的联系作为疾病的基础。 具体目标2。在AIM的研究范围内培养足够数量的研究人员， 基础设施，使初级教师的职业发展，并为研究人员提供指导支持， 获得独立的NIH资助。 具体目标3。建立科学核心，以使目前和未来的一批接受辅导的专业研究人员，以及 UNM HSC和新墨西哥州的科学界。 AIM将促进当地科学资源的增长，补充现有设施而不重叠， 优秀的教师队伍，并增加研究经费的机构和全州。AIM将与 其他新墨西哥州的IDEA中心，并在不复制现有核心、设施和共享 联合国墨西哥大学HSC和该区域的资源。

SUMMARY Autophagy is a fundamental homeostatic and metabolic intracellular process operational in all healthy human cells. Autophagy sustains cellular metabolic needs during starvation or growth factor withdrawal, cleanses the cell interior by removing damaged organelles and toxic protein aggregates, and rids cells of endogenous or exogenous promoters of inflammation. Increasingly studied, autophagy broadly affects human health and disease with disorders ranging from inflammatory, metabolic (diabetes, obesity), infection, autoimmune, cancer, neurodegeneration, and aging. The proposed Center of Biomedical Research Excellence (CoBRE) for Autophagy, Inflammation, and Metabolism (AIM) in Disease will serve biomedical excellence for mentored research on autophagy and its interactions with inflammatory and metabolic processes. Both New Mexico and the nation lack a program to develop faculty and coherent research programs in this novel, evolving area with translational implications. With regional and national implications, AIM will close that gap. University of New Mexico Health Sciences Center (UNM HSC) employs national and international leaders in autophagy plus junior investigators exploring the intersections of inflammation, metabolism, and other processes with autophagy. UNM HSC offers (i) institutional support, (ii) future faculty hires, (iii) translational resources (Clinical and Translational Science Center), (iv) faculty mentoring, and (v) effective infrastructure to secure AIM as a national center of excellence. In turn, AIM will provide state-of-the-art equipment, technical expertise, training, and mentoring to win R01 funding for multiple new projects. AIM will build on the strength of the initial cohort of investigators and mentors, recruit new investigators, and develop a sustainable center to meet Institutional Development Award (IDeA) program goals. Specific Aim 1. Establish a nationally recognized AIM CoBRE to pioneer the study of autophagy and its connections with inflammation and metabolism as a basis of disease. Specific Aim 2. Develop a critical mass of investigators within AIM's research scope, establish mentoring infrastructure to enable junior faculty career development, and provide mentoring support for investigators to achieve independent NIH funding. Specific Aim 3. Establish scientific cores to enable present and future cohorts of mentored PIs, as well as the scientific community at UNM HSC and New Mexico. AIM will enable local growth in scientific resources, complement existing facilities without overlaps, develop a cadre of excellent faculty, and increase research funding institutionally and statewide. AIM will interface with other New Mexico IDeA centers and synergize without duplicating existing cores, facilities, and shared resources at UNM HSC and the region.