Neural basis of cognitive reserve: fMRI/TMS studies of memory and aging

认知储备的神经基础：记忆和衰老的 fMRI/TMS 研究

• 批准号: 8323373
• 负责人: Bruce Luber
• 金额: $ 13.04万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8323373
• 关键词: Affect; Aging; Biological Neural Networks; Brain; Clinical; Clinical Trials Design; Cognitive; Dementia; Development Plans; Elderly; Financial compensation; Functional Magnetic Resonance Imaging; Goals; Image; Impaired cognition; Intervention; Knowledge; Lead; Measures; Mediating; Memory; Memory Loss; Mentored Research Scientist Development Award; Multivariate Analysis; Nerve Degeneration; Neurobiology; Neurosciences; Performance; Positioning Attribute; Relative (related person); Research Personnel; Research Training; Role; Short-Term Memory; Site; Sleep Deprivation; System; Testing; Translating; Work; age effect; age related; base; career development; cognitive function; cognitive neuroscience; cognitive reserve; experience; improved; innovation; neuroimaging; novel; relating to nervous system; resilience; skills; tool; treatment strategy; young adult

Neural degeneration invariably accompanies aging, yet some elders are able to maintain excellent cognitive function. The capacity to sustain function in the face of aging and illness is called cognitive reserve. Knowledge of the neural basis underlying cognitive reserve would inform treatment strategies for cognitive decline and dementia. This Mentored Research Scientist Development Award (K01) will provide Dr. Bruce Luber with the necessarytraining and skills to become an independent investigator with expertise in the neural basis of cognitive reserve, applying innovative tools that may ultimately lead to novel interventions for age related memory loss. Cognitive reserve is thought to be mediated by two mechanisms: (1) resilience of existing neural networks to the effects of aging (neural reserve), and (2) compensation through enlistment of new networks. Functional neuroimaging studies have generated hypotheses regarding the neural basis of these aspects of cognitive reserve, but cannot test causal relationships. This K01 will equip the candidate to test the neural basis of both aspects of cognitive reserve, using image-guided noninvasive brain stimulation. The specific aims are: to identify neural reserve and compensation networks related to working memory in the elderly using fMRI and advanced multivariate analysis comparing young and older adults (Aim 1), and to validate the functional role of neural reserve (Aim 2) and compensation (Aim 3) networks using fMRI-guided TMS. This work extends the candidate's studies showing that fMRI-guided TMS targeted to a reserve network can improve working memory performance at baseline and following sleep deprivation. The career development plan will provide expertise in: 1) the cognitive neuroscience of aging, 2) the clinical use of TMS, 3) the use of fMRI-guided TMS as a neurobiological probe, 4) clinical trial design and statistical analysis, and 5) systems neuroscience. This training and research experience will position Dr. Luber to achieve his long- term goal to translate an advanced understanding of the mechanisms of cognitive reserve into novel tools to study and ultimately to better treat cognitive decline in the elderly.

神经退化不可避免地伴随着年龄的增长，但一些老年人仍能保持良好的认知能力

项目成果

Applications of transcranial magnetic stimulation and magnetic seizure therapy in the study and treatment of disorders related to cerebral aging.

• DOI: 10.31887/dcns.2013.15.1/bluber
• 发表时间: 2013-03
• 期刊: Dialogues in clinical neuroscience
• 影响因子: 8.3
• 作者: Luber B;McClintock SM;Lisanby SH
• 通讯作者: Lisanby SH

Self-enhancement processing in the default network: a single-pulse TMS study.

• DOI: 10.1007/s00221-012-3249-7
• 发表时间: 2012-11
• 期刊: EXPERIMENTAL BRAIN RESEARCH
• 影响因子: 2
• 作者: Luber, Bruce;Lou, Hans C.;Keenan, Julian P.;Lisanby, Sarah H.
• 通讯作者: Lisanby, Sarah H.

Enhancement of human cognitive performance using transcranial magnetic stimulation (TMS).

• DOI: 10.1016/j.neuroimage.2013.06.007
• 发表时间: 2014-01-15
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Luber B;Lisanby SH
• 通讯作者: Lisanby SH