UNDERSTANDING THE EFFECTS OF STROKE USING FUNCTIONAL CONNECTIVITY MRI

使用功能连接 MRI 了解中风的影响

• 批准号: 8300153
• 负责人: Maurizio Corbetta
• 金额: $ 57.83万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-20 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8300153
• 关键词: Acute; Adult; Affect; Anatomy; Aphasia; Attention; Behavior; Behavioral; Biological Neural Networks; Blood Vessels; Brain; Brain region; Cerebral Peduncle; Chronic; Clinical; Contralateral; Data Set; Diagnosis; Distant; Environment; Focal Brain Injuries; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Grant; Health; Hemiplegia; Individual; Internal Capsule; Intervention; Language; Language Disorders; Left; Lesion; Lower Extremity; Magnetic Resonance Imaging; Measurement; Measures; Memory; Methods; Middle Cerebral Artery Infarction; Monitor; Motor; Motor Cortex; Neurosciences; Outcome; Output; Parietal Lobe; Pathway interactions; Patients; Pattern; Performance; Physiological; Physiology; Recovery; Recovery of Function; Recruitment Activity; Sampling; Sensory; Signal Transduction; Site; Specificity; Speed; Staging; Stroke; System; Testing; Thalamic structure; Time; Upper Extremity; Visual Fields; Work; abstracting; acute stroke; arm; base; blood oxygen level dependent; clinically significant; cognitive neuroscience; hemiparesis; indexing; injured; motor control; motor deficit; motor impairment; neglect; network dysfunction; neural patterning; neuromechanism; novel; outcome forecast; putamen; relating to nervous system; spatial neglect; tool; white matter

Abstract (Official) DESCRIPTION (provided by applicant): The relationship between the behavioral deficits and anatomical damage produced by a stroke is only partial, since physiological dsyfunction can be measured in brain regions far removed from the lesion. These non-local physiological deficits can be assessed using functional connectivity magnetic resonance imaging (fcMRl), which measures the temporal correlation between brain regions in the blood-oxygenation-level-dependent (BOLD) signal. Studies of fcMRl in healthy adults have identified distributed brain networks that underlie different behavioral functions, such as attention, motor control, and language. Our previous work on stroke patients with spatial neglect has shown that fcMRl deficits within the attention network correlate with a patient's deficit in the neglected field. This grant proposes that fcMRl can be used more broadly to understand the deficits produced by stroke across behavioral domains. We will measure fcMRl in a large, heterogeneous sample of stroke patients, and test several hypotheses of how strokes produce dysfunction in brain networks and how this dysfunction correlates with behavioral deficits. We predict that decreases in inter-hemispheric connectivity in motor and attention networks, which are bilaterally organized, will correlate with corresponding behavioral deficits and that these correlations will show functional specificity. For example, connectivity within an arm-defined motor network will predict upper-extremity function better than lower-extremity function. We determine the correlation between connectivity and behavior in an asymmetrically organized network, language, and compare the importance of inter-hemispheric vs intra-hemispheric connectivity. We examine how the functioning of multiple brain networks interact to produce a single behavioral deficit, and hypothesize that the connectivity of some networks, such as attention, correlates with behavior across domains. We measure fcMRl longtitudinally to determine if connectivity recovers in different networks at different rates and whether that recovery correlates with behavioral recovery. Finally, we study how changes in connectivity produced by a stroke depend on the type of tracts that are structurally damaged.

摘要(官方) 描述(申请人提供)：行为缺陷和中风造成的解剖损伤之间的关系只是部分的，因为生理功能障碍可以在远离病变的大脑区域进行测量。这些非局部生理缺陷可以使用功能连接磁共振成像(FcMRl)来评估，该成像测量了血氧水平依赖(BOLD)信号中脑区之间的时间相关性。对健康成年人的fcmrl的研究发现，分布式大脑网络构成了不同行为功能的基础，如注意力、运动控制和语言。我们之前对具有空间忽视的中风患者所做的工作表明，注意网络中的fcmrl缺陷与患者在被忽视领域的缺陷相关。这项授权建议，fcMRl可以被更广泛地用于理解中风跨行为领域产生的缺陷。我们将在大量不同种类的中风患者样本中测量fcMR1，并测试关于中风如何导致大脑网络功能障碍以及这种功能障碍如何与行为缺陷相关的几个假说。我们预测，在双边组织的运动和注意网络中，大脑半球间连通性的下降将与相应的行为缺陷相关，并且这些相关性将显示出功能特异性。例如，手臂定义的运动网络中的连通性将比下肢功能更好地预测上肢功能。我们确定了在不对称组织的网络、语言中连通性和行为之间的相关性，并比较了半球间连通性与半球内连通性的重要性。我们研究了多个大脑网络的功能如何相互作用，从而产生单一的行为缺陷，并假设某些网络的连接性，如注意力，与跨域行为相关。我们对fcMR1进行纵向测量，以确定不同网络中的连通性是否以不同的速率恢复，以及这种恢复是否与行为恢复相关。最后，我们研究了中风引起的连通性变化如何依赖于结构受损的神经束的类型。