ELECTROPHYSIOLOGICAL STUDIES OF HUMAN ATTENTION

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DESCRIPTION (provided by applicant): Neuroimaging studies have provided a wealth of information on the cortical and subcortical regions of the human brain active during cognitive tasks. Recent studies have shown that regions that are co-activated during tasks maintain, even at rest, a high level of inter-regional correlation, or 'functional connectivity'. However, these interregional correlations are measured over long time scales (e.g. minutes). In contrast, little is known about the temporal dynamics and interactions of these brain regions over the short timescales (e.g. sec or ms) that are typical of most tasks. The analysis of temporal dynamics and interactions is strongly limited by the low temporal resolution of neuroimaging methods (functional magnetic resonance imaging, fMRI; Positron emission tomography, PET), and the low spatial resolution of methods for recording extracranial electro-magnetic activity (electroencephalography, EEG, magnetoencephalography, MEG). To solve these fundamental limitations, we have combined fMRI measures of blood-oxgyenation-level- dependent (BOLD) signals with electrocorticographic (ECoG) signals recorded from invasively monitored human subjects. We have developed methods to co-register functional networks localized with fMRI with intracranial electrodes that record surface cortical local field potentials (LFP). We have applied these novel methods to study the dynamics and interactions of cortical networks involved in spatial attention. Our preliminary results indicate that cortical networks observed with fMRI during a spatial attention task show multiple coherence modulations with ECoG. Maintenance of spatial attention correlates with sustained phase synchronization in the delta band (1-3 Hz) across multiple occipital, parietal, and frontal task-relevant regions, while shifts of spatial attention are associated with transient increases of phase synchronization in the theta band (3-7 Hz). We propose a series of experiments in which we first localize with fMRI cortical regions/networks specialized for spatial attention and then study their dynamics and interaction with ECoG on well- characterized cognitive tasks. Our first specific aim is to determine the role of delta/theta band phase synchronization in linking cortical regions during voluntary orienting of spatial attention. Our second specific aim studies how delta/theta band phase synchronization is affected by the temporal structure of a task. Our third specific aims focuses on the interaction between two different attention networks (dorsal, DAN; ventral, VAN) during stimulus-driven re-orienting.