How the organization of the cell membrane determines T lymphocytes activation

细胞膜的组织如何决定 T 淋巴细胞的激活

• 批准号: nhmrc : GNT1062104
• 负责人: A/Pr Daniel Hatters
• 金额: $ 38.76万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/organization-cell-membrane-lymphocytes-activation/1344798
• 关键词: How; organization; cell; membrane; determines

To function in an immune response, T cell become activated when the interactions between the T cell receptor and the kinase Lck on the cell surface results in intracellular signals. Here, we will investigate how the kinase is organized on the cell surface during receptor activation and what intrinsic and extrinsic parameters regulate its organization. The research is based on novel single molecule imaging tools and will provide new insights into the regulation of T cell activation.

为了在免疫应答中发挥作用，当T细胞受体和细胞表面的激酶Lck相互作用产生细胞内信号时，T细胞被激活。在这里，我们将研究在受体激活过程中激酶是如何在细胞表面组织的，以及哪些内在和外在参数调节了它的组织。这项研究基于新颖的单分子成像工具，将为T细胞活化的调控提供新的见解。