How the organization of the cell membrane determines T lymphocytes activation

为了在免疫反应中发挥作用，当T细胞受体和细胞表面的激酶Lck之间的相互作用产生细胞内信号时，T细胞就会被激活。在这里，我们将研究在受体激活过程中，该激酶是如何在细胞表面组织的，以及什么内在和外在参数调节其组织。这项研究基于新的单分子成像工具，将为调节T细胞激活提供新的见解。

To function in an immune response, T cell become activated when the interactions between the T cell receptor and the kinase Lck on the cell surface results in intracellular signals. Here, we will investigate how the kinase is organized on the cell surface during receptor activation and what intrinsic and extrinsic parameters regulate its organization. The research is based on novel single molecule imaging tools and will provide new insights into the regulation of T cell activation.