Viewing the cellular responses in Huntington’s disease through an aggreomics framework

通过聚集组学框架观察亨廷顿病的细胞反应

• 批准号: nhmrc : 1049458
• 负责人: A/Pr Daniel Hatters
• 金额: $ 24.22万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/viewing-cellular-responses-aggreomics-framework/112084
• 关键词: Viewing; cellular; responses; Huntington; disease

Huntington disease results from a mutation that causes the Htt protein to form abnormal toxic clusters in neurons that eventually leads to cell death. This project will develop and apply new technology to identify how the clustering process damages cells and will measure all the gene expression changes that occur during the clustering process. The project offers much potential for revealing new therapeutic targets to this incurable disease.

亨廷顿病是由一种突变引起的，这种突变导致Htt蛋白在神经元中形成异常的毒性簇，最终导致细胞死亡。该项目将开发和应用新技术来确定聚类过程如何损害细胞，并将测量聚类过程中发生的所有基因表达变化。该项目为揭示这种不治之症的新治疗靶点提供了很大的潜力。