Spatial organization of Lck as a regulatory mechanism of TCR signalling

Lck 的空间组织作为 TCR 信号传导的调节机制

• 批准号: nhmrc : 1062104
• 负责人: A/Pr Daniel Hatters
• 金额: $ 40.09万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/spatial-organization-lck-tcr-signalling/454960
• 关键词: Spatial; organization; Lck; regulatory; mechanism

To function in an immune response, T cell become activated when the interactions between the T cell receptor and the kinase Lck on the cell surface results in intracellular signals. Here, we will investigate how the kinase is organized on the cell surface during receptor activation and what intrinsic and extrinsic parameters regulate its organization. The research is based on novel single molecule imaging tools and will provide new insights into the regulation of T cell activation.

为了在免疫应答中发挥作用，当T细胞受体与细胞表面上的激酶Lck之间的相互作用导致细胞内信号时，T细胞被激活。在这里，我们将研究激酶是如何组织在细胞表面的受体活化过程中，什么内在和外在的参数调节其组织。该研究基于新型单分子成像工具，将为T细胞活化的调控提供新的见解。