Proteostasis mechanics of neurodegenerative diseases

神经退行性疾病的蛋白质稳态机制

• 批准号: nhmrc : GNT1154352
• 负责人: A/Pr Daniel Hatters
• 金额: $ 64.92万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/proteostasis-mechanics-neurodegenerative-diseases/1349136
• 关键词: Proteostasis; mechanics; neurodegenerative; diseases

The main feature of many neurodegenerative diseases is inappropriate protein aggregation arising from protein homeostasis (proteostasis) imbalance. My vision is to capitalize on a suite of new methods I have established to determine how breakdown in cellular mechanisms that govern proteostasis relates to neurodegenerative diseases. This knowledge will lead to new diagnostic approaches, therapeutic targets and drugs to treat diseases including Alzheimer and Huntington diseases.

许多神经退行性疾病的主要特征是蛋白质稳态（蛋白质稳态）失衡引起的不适当的蛋白质聚集。我的愿景是利用我已经建立的一套新方法来确定控制蛋白质稳态的细胞机制的崩溃与神经退行性疾病的关系。这些知识将导致新的诊断方法，治疗目标和药物，以治疗包括阿尔茨海默病和亨廷顿病在内的疾病。