Training Program in Ion Channel and Transporter Biology

描述（由申请人提供）：项目摘要/摘要离子通道和转运蛋白是普遍存在的分子，具有多种重要的生理功能，为许多类型的药理学试剂提供靶点，并且由基因编码，这些基因可能是影响神经系统和其他组织的遗传性疾病的基础。该提案描述了离子通道和转运蛋白生物学培训计划的延续，该计划将为博士后科学家提供多学科研究培训。这个高度集中的培训计划涉及30名NIH资助的导师（总资金> 31，500，000美元直接成本/年），隶属于范德比尔特大学的13个不同的学术部门和10个研究中心，在离子通道和转运蛋白领域取得了很好的成绩，并致力于培养博士后研究员。该跨部门培训计划利用了该研究领域近20年的机构和多学科力量的历史。该计划最初于2001年开始，只有19名教师，并成功地填补了自那时以来所有资助的职位。虽然培训计划最初包括博士前培训，但参与教师的共识是将该计划集中在博士后学员上，以实现更连贯的培训计划，并扩大博士后职位的数量。博士后培训生将从申请导师实验室的申请人中选出，并由范德比尔特大学举办年度招聘活动。将继续采取多方面的征聘战略，从任职人数不足的群体中吸引高素质的个人。除了密集的研究经验，学员将有教学课程的要求，其中包括一个重点课程补助金写作，一个创新的研讨会系列致力于鼓舞人心的转化研究，正式的辅导和职业指导。教师导师的高素质，培训机会的跨学科性质，强大的机构优势联合收割机结合起来，以促进适合培训计划的目标，这是培养科学家与坚定的承诺，在离子通道和转运生物学领域的学术生物医学研究的独特环境。 公共卫生相关性：项目叙述离子通道和转运蛋白是重要的分子，可发挥多种重要的细胞功能，为多种类型的药物提供靶点，并参与许多影响神经系统和其他器官的获得性和遗传性疾病。该提案描述了离子通道和转运蛋白生物学培训计划的延续，该计划将为该领域的科学家提供多学科研究培训。

DESCRIPTION (provided by applicant): Project Summary/Abstract Ion channels and transporter proteins are ubiquitous molecules that serve a variety of important physiological functions, provide targets for many types of pharmacological agents, and are encoded by genes that can be the basis for inherited diseases affecting the nervous system and other tissues. This proposal describes the continuation of a Training Program in Ion Channel and Transporter Biology that will provide multidisciplinary research training for postdoctoral scientists. This highly focused training program involves 30 NIH-funded preceptors (aggregate funding >$31,500,000 direct costs/year) affiliated with 13 different academic departments and 10 research centers at Vanderbilt University with strong records of accomplishments in the ion channel and transporter field, and with a deep commitment to training postdoctoral fellows. This interdepartmental training program capitalizes on a nearly 20-year history of institutional and multidisciplinary strength in this research field. The program began initially in 2001 with only 19 faculty and has successfully filled all funded positions since that time. Although the training program originally included predoctoral training, the consensus of the participating faculty members was to focus the program on postdoctoral trainees to enable a more coherent training program and to expand the number of available postdoctoral positions. Postdoctoral trainees will be selected from the pool of applicants that apply to preceptor laboratories as well as by an annual recruitment event hosted by Vanderbilt University. A multi-faceted recruitment strategy will continue to attract highly qualified individuals from underrepresented groups. In addition to intensive research experiences, trainees will have didactic course requirements that include a focused course on grant writing, an innovative seminar series devoted to inspiring translational research, formal mentoring and career guidance. The high caliber of faculty mentors, the interdisciplinary nature of training opportunities, the strong institutional strengths combine to foster a unique environment suited to the goal of the training program, which is to develop scientists with strong commitments to academic biomedical research in the area of ion channel and transporter biology. PUBLIC HEALTH RELEVANCE: Project Narrative Ion channels and transporter proteins are important molecules that serve a variety of important cellular functions, provide targets for many types of drugs, and are involved in many acquired and inherited diseases affecting the nervous system and other organs. This proposal describes the continuation of a Training Program in Ion Channel and Transporter Biology that will provide multidisciplinary research training for scientists in this field.