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PS07-003, Minority HIV/AIDS Research Initiative (MARI)

PS07-003，少数群体艾滋病毒/艾滋病研究计划 (MARI)

基本信息

批准号：
8307266
负责人：
Emma J Brown
金额：
$ 9.12万
依托单位：
CHARM, INC.
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-30 至 2012-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8307266
关键词：
PS07 003 Minority HIV AIDS

项目摘要

DESCRIPTION (provided by applicant): The study proposed in this application addresses the second new strategy for HIV prevention under CDC's Advancing HIV Prevention (AHP) initiative; the implementation of new models for diagnosing HIV infections outside medical settings and one of the six research objectives of the RFA, Voluntary HIV testing and counseling of heterosexual Black and Hispanic males. The short-term study objective is to identify barriers and facilitators associated with HIV testing and disclosure of HIV+ test results-- black males18 - 64 who self- identify as heterosexual--determining whether these differ by relationship type (wife, regular outside female sexual partner, causal female sexual partner, male sexual partner) and to determine if providing HIV testing options will result in increase acceptability of HIV testing. The long-term objective is to develop an intervention to promote HIV testing and disclosure of HIV positive status to sexual partners that is cultural, gender, and region specific for rural/small city African American males who self-identify as heterosexual. The study design consists of four phases; Phase 1-Qualitative Descriptive focus groups (n=36) to inform the development of the survey items, Phase 2-Cross-sectional Instrument Developments and Testing (n=300) utilizing a mixed method approach of instruments administration and focus groups, Phase 3-Cross- sectional survey administration (n=3000) and randomized controlled trial at the individual level (n=300) comparing experimental condition with rapid HIV testing procedure (OraQuick Rapid HIV-1/2 Antibody or OraQuick Advance Rapid HIV-1/2 Antibody) via community outreach with the controlled condition/standard non-rapid OraSure or serological test, and Phase 4-Qualitative Descriptive process evaluation utilizing 12 focus groups (N=72, n=36 survey participants who did not participate in the randomized controlled trial and n=36 participants of the randomized controlled trial) to assess attitude toward HIV testing, perception of barriers to and facilitators of HIV testing, perception of assistance needed to improve HIV+ disclosure skills, and perception of strategies to improve HIV testing. The objective of this research has public health relevance to the Black community related to HIV. Three Healthy People 2010 objectives are addressed by this proposed research; 13-7 Increase the number of HIV- positive persons who know their serostatus, 3-13 Increase the proportion of HIV-infected adolescents and adults who receive testing, treatment, and prophylaxis consistent with current Public Health Service treatment guidelines, and 5-8 Reduce HIV infections in adolescent and young adult females aged 13 to 24 years that are associated with heterosexual contact. The objective of this research has public health relevance to the Black community related to HIV. Three Healthy People 2010 objectives are addressed by this proposed research: 13-7, Increase the number of HIV- positive persons who know their serostatus; 3-13, Increase the proportion of HIV-infected adolescents and adults who receive testing, treatment, and prophylaxis consistent with current Public Health Service treatment guidelines; and 5-8, Reduce HIV infections in adolescent and young adult females aged 13 to 24 years that are associated with heterosexual contact.

描述（由申请人提供）：本申请中提出的研究解决了CDC推进艾滋病毒预防（AHP）倡议下的第二个艾滋病毒预防新战略;实施新的诊断艾滋病毒感染的模式，以及RFA的六个研究目标之一，异性恋黑人和西班牙裔男性的自愿艾滋病毒检测和咨询。短期研究的目标是确定与艾滋病毒检测和艾滋病毒+检测结果披露相关的障碍和促进因素--自我认同为异性恋的18 - 64岁黑人男性--确定这些因素是否因关系类型而异（妻子，固定的外部女性性伴侣，因果关系的女性性伴侣，男性性伴侣），并确定提供艾滋病毒检测选择是否会增加艾滋病毒检测的可接受性。长期目标是制定一项干预措施，以促进艾滋病毒检测和披露艾滋病毒阳性状态的性伙伴，这是文化，性别和区域特定的农村/小城市非洲裔美国男性谁自我认同为异性恋。研究设计包括四个阶段;第1阶段-定性描述性焦点小组（n=36），以告知调查项目的开发，第2阶段-横断面仪器开发和测试（n=300），采用仪器管理和焦点小组的混合方法，3期-横断面调查管理（n=3000）和个体水平的随机对照试验（n=300），比较实验条件与快速HIV检测程序（OraQuick Rapid HIV-12 Antibody或OraQuick Advance Rapid HIV-12 Antibody），通过受控条件/标准非快速OraSure或血清学检测进行社区外展，以及第4阶段-使用12个焦点小组进行定性描述性工艺评价（N=72，n=36名未参加随机对照试验的调查参与者和n=36名随机对照试验的参与者）评估对HIV检测的态度，对艾滋病毒检测的障碍和促进因素的看法，对改善艾滋病毒+披露技能所需援助的看法，以及对改善艾滋病毒检测战略的看法。这项研究的目的与艾滋病毒相关的黑人社区的公共卫生相关性。这项拟议的研究涉及到2010年健康人的三个目标; 13-7增加了解自己血清状况的艾滋病毒阳性者的人数，3-13增加感染艾滋病毒的青少年和成年人接受符合公共卫生服务现行治疗准则的检测、治疗和预防的比例，5-8减少13至24岁青少年和年轻成年女性与异性性接触有关的艾滋病毒感染。这项研究的目的与艾滋病毒相关的黑人社区的公共卫生相关性。这项拟议的研究涉及三个2010年健康人目标：13-7，增加了解其血清状况的艾滋病毒阳性者的人数; 3-13，增加感染艾滋病毒的青少年和成年人接受符合现行公共卫生服务治疗准则的检测、治疗和预防的比例;和5-8，减少13至24岁青少年和年轻成年女性与异性性接触有关的艾滋病毒感染。