Imaging

影像学

• 批准号: 8287308
• 负责人: HOWARD J ROSEN
• 金额: $ 16.05万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8287308
• 关键词: Address; Adopted; Affect; Alzheimer' s Disease; Amyloid; Archives; Atrophic; Behavior; Behavioral; Binding; Biological Markers; Brain; Brain imaging; Brain region; Clinical; Clinical assessments; Cognitive deficits; Collaborations; Collection; Complex; Consult; Consultations; Data; Databases; Deformity; Diagnosis; Diagnostic; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Emotional; Emotions; Ensure; Frontotemporal Dementia; Functional Imaging; Functional Magnetic Resonance Imaging; Genes; Goals; Image; Image Analysis; Imaging Techniques; Impaired cognition; Individual; Instruction; Link; Magnetic Resonance Imaging; Maintenance; Measures; Memory; Metabolism; Multimodal Imaging; Mutation; Neurodegenerative Disorders; Output; Patients; Pattern; Perfusion; Positron-Emission Tomography; Process; Program Research Project Grants; Protocols documentation; Regional Perfusion; Relative (related person); Research; Research Personnel; Resources; Rest; Role; Sampling; Schedule; Site; Spin Labels; Techniques; Temporal Lobe; Thick; Time; Tracer; Weight; Work; amyloid imaging; base; brain behavior; frontal lobe; glucose metabolism; gray matter; image archival system; imaging modality; morphometry; multimodality; neuroimaging; novel; response; social; tool; white matter

PROJECT SUMMARY (See instructions): The proposed project is a plan to add an imaging core to the UCSF Program Project Grant, entitled: Frontotemporal Dementia: Genes, Images and Emotions. This new core for this PPG is a response to the increasing complexity of imaging and increased use of imaging to answer questions related to FTD. Since the inception of this PPG, the number of techniques for brain imaging has expanded significantly. Our group began using structural imaging as the mainstay for anatomical assessment of FTD, and has moved on to embrace diffusion tensor imaging (DTI), arterial spin labelled perfusion (ASL) and intrinsic connectivity functional MRI (ICN fMRI), as well as FDG-PET and PIB-PET. A major goal for the next cycle of the PPG will be to investigate the relative utility of these various techniques, alone or in combination, for diagnosis and for delineating brain-behavior relatioships in FTD. Many of the cores and projects will make use of these various types of imaging modalities. While two other projects will investigate sophisticated new anaytic approaches for multimodality imaging (Project 2) and ICN fMRI (Project 6), this imaging core will facilitate use of images by these projects and the rest of the PPG by ensuring acquistion and archiving of high quality images, performing basic pre-processing, and providing basic imaging data and images. Specifically, Core E will: 1) collect and manage the following MRI sequences at 3Tesla in patients with bvFTD, nfvPPA, svPPA, IvPPA, CBS, PSPS, ALS, memory-predominant cognitive deficits (MEM), asymptomatic carriers of FTLD-causing mutations (MUT) and controls: MP-RAGE, FLAIR, T2-weighted, DTI, ASL perfusion, and ICN fMRI. We will also acquire [18FJFDG and [1 ICjPIB PET scans, 2) preprocess MR images including RF field bias and geometrical distortion corrections and coregistration of all images to each subject's "native space", 3) process Tl-weighted images with FreeSurfer (FS) and derive cortical thickness and volumes, regional perfusion, FDG-metabolism, and normalized amyloid tracer binding values for standard ROIs in FS space, 4) consult with Pis and staff serving the other PPG projects and cores on incorporating imaging data into their analyses.

项目概述（见说明）：