Biostatistics and Bioinformatics Core

项目总结（见说明）： 生物统计学和生物信息学戈尔服务于规划和开展 SPORE的基础和转化研究。戈尔提供了假设细化，实验设计， 分析，数据管理，并在整个SPORE的所有项目的结果提供翔实的介绍。从 一个生物统计学的角度来看，设计和分析实验室和临床项目是在 彼得·穆勒博士的指导。Caimiao Wei博士将她的专业知识贡献给微阵列分析， 基因组数据在这个孢子。来自SPORE临床试验、动物研究和实验室实验的数据 在Chariotte Sun博士、Mark Munsell先生和Diana Urbauer女士的支持下进行分析。乔纳斯博士 阿尔梅达将监督数据库管理和数据集成。数据集成将建立在一个新的 部署现有的数据服务SSDB。此SPORE资源用于增强现有的M.D. 安德森生物统计学和生物信息学资源，并将这些可观的资源与孢子 研究目标。 生物统计学和生物信息学戈尔的具体目标是： 具体目标1：为临床试验和其他实验的设计和实施提供指导 正在进行的孢子研究。 具体目标2：提供创新的统计建模、模拟技术和数据分析 项目、发展项目和其他戈尔为实现其特定目标所需的信息。 具体目标3：确保所有项目的结果都基于精心设计的实验， 适当的解释。 具体目标4：提供一个基于网络的环境，使数据库可以在 多机构子宫孢子科学界。

PROJECT SUMMARY (See instructions): The Biostatistics and Bioinformatics Gore serves multiple needs for the planning and conduct of the SPORE'S basic and translational research. The Gore provides hypothesis refinement, experimental design, analysis, data management, and informative presentation of results across all projects of the SPORE. From a biostatistical perspective, design and analysis of laboratory and clinical projects are performed at the direction of Dr. Peter Mueller. Dr. Caimiao Wei contributes her expertise to the analysis of microarray and genome data in this SPORE. Data from SPORE clinical trials, animal studies, and laboratory experiments are analyzed with the support of Dr. Chariotte Sun, Mr. Mark Munsell, and Ms. Diana Urbauer. Dr. Jonas Almeida will oversee data base management and data integration. Data integration will build on a new deployment of the existing data service SSDB. This SPORE resource is used to augment existing M.D. Anderson biostatistics and bioinformatics resources and to align these considerable resources with SPORE research objectives. The Specific Aims ofthe Biostatistics and Bioinformatics Gore are: Specific Aim 1: To provide guidance in the design and conduct of clinical trials and other experiments arising from the ongoing research ofthe SPORE. Specific Aim 2: To provide the innovative statistical modeling, simulation techniques, and data analyses needed by the Projects, Developmental Projects, and other Gores to achieve their Specific Aims. Specific Aim 3: To ensure that the results of all Projects are based on well-designed experiments and are appropriately interpreted. Specific Aim 4: Provide a web-based environment where data bases can be created and shared within the multi-institutional Uterine SPORE scientific community.