7T Small Animal MRI Scanner

7T小动物核磁共振扫描仪

• 批准号: 8247332
• 负责人: SRINIVASAN MUKUNDAN
• 金额: $ 60万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8247332
• 关键词: Anesthesia procedures; Animals; Award; Brain Neoplasms; Cardiac; Childhood; Development; Diffusion Magnetic Resonance Imaging; Electronics; Environment; Functional Imaging; Goals; Grant; Hospitals; Housing; Human; Human body; Image; Laboratories; Magnetic Resonance Imaging; Magnetism; Microsurgery; Mission; Modeling; Monkeys; Mus; Noise; Nuclear; Positioning Attribute; Predisposition; Preparation; Prostate; Rattus; Research; Research Infrastructure; Research Personnel; Resources; Services; Signal Transduction; Stroke; System; Tissue Sample; Translational Research; Woman; base; falls; innovation; instrument; medical schools; new technology; next generation; programs

DESCRIPTION (provided by applicant): The Brigham MRI Research Center (BMRC), located in the Eugene Braunwald Research Center at 221 Longwood Avenue, provides essential research MRI services to investigators at Brigham and Women's Hospital and the Longwood Campus of Harvard Medical School. In 2010, the BMRC was awarded a G20 grant to support the first major renovation of this resource since 1991. This vital renovation provides the needed infrastructural improvements to facilitate advanced MRI research to proceed, grow, and flourish at this center. In its current configuration, the BMRC has 3 MRI scanner bays that house whole-body human scanners (one GE 1.5 Tesla (T), one GE 3.0T magnet, and an empty bay. The new BMRC will feature a next-generation 3.0 T Siemens scanner in addition to the existing scanners. The most innovative feature of the redesigned BMRC will be the integration of a small animal imaging laboratory (SAIL) into what was previously a predominantly human imaging center. The overarching goal of the BMRC redesign is to develop a more naturally collaborative environment by providing a comprehensive, translational research infrastructure. The SAIL, which will encompass an animal handling suite in addition to the MR imaging suite, is mission critical to this effort. The animal handling suite will house a satellite vivarium for mice and rats, and an animal preparation lab complete with anesthesia resources for performing microsurgery. The animal imaging suite will consist of a control room, imaging bay and electronic support room. The original plan to install a "state-of-the-art high field strength (9.4 or 11.7T) small bore animal system" was based solely on signal-to-noise ratio (SNR) gains that are proportional to field strength. Two critical developments over the past year have provided cause to modify this position. First, is the commercial availability of a novel technology, the cryoprobe, that yields marked improvements in SNR, while avoiding the confounding physical phenomena of magnetic susceptibility, dielectric effects, and T2*-shortening that worsen with increasing field strength. Moreover, cryoprobe SNR improvements are inversely related to field strength, with a three-fold SNR increase at 7T, falling to 1.5 fold at 11.7 T. The second is that the vintage 4.7T small bore animal scanner located separately at Harvard Medical School has been decommissioned, resulting in a call by some users to stay in the 7T range. Therefore, we offer this proposal to assist in the acquisition of a 7T 20 cm horizontal bore Bruker system with a cryoprobe. In addition to being conducive to a vibrant animal imaging program, the new scanner will enhance the interaction between animal and human re searchers. For example, the x-nuclear capability will allow imaging of hyperpolarized gasses. This is one of the unique MRI programs at the BWH, and will leverage the hyperpolarizer being installed in the BMRC. Similarly, the new instrument will facilitate ongoing research in cardiac imaging in mouse, prostate imaging in mouse, and functional imaging in pediatric monkeys, and diffusion tensor imaging in tissue samples. Next generation offering will include brain tumors in mouse, and murine neurovascular imaging in stroke models. PUBLIC HEALTH RELEVANCE: The Brigham MRI Research Center (BMRC), located in the Eugene Braunwald Research Center at 221 Longwood Avenue is undergoing a significant renovation as the result of a G20 grant. We propose to acquire a 7T 20cm small animal MRI scanner to help facilitate the overarching BMRC goal of becoming a state of the art translational center. The new instrument would support several existing NIH funded projects and investigators covering the spectrum from cardiology (hypertrophy, genetics), pulmonology (hyperpolarized gas exchange), prostate imaging, to neuroscience (diffusion tensor imaging, brain tumor imaging, and stroke imaging).

描述（由申请人提供）：布里格姆MRI研究中心（BMRC）位于朗伍德大道221号的尤金布劳恩沃尔德研究中心，为布里格姆妇女医院和哈佛医学院朗伍德校区的研究人员提供必要的研究MRI服务。2010年，BMRC获得了G20赠款，以支持自1991年以来首次对该资源进行重大改造。这一重要的改造提供了所需的基础设施改进，以促进先进的MRI研究在该中心进行，发展和繁荣。在其当前配置中，BMRC有3个MRI扫描仪机架，可容纳全身人体扫描仪（一个GE 1.5特斯拉（T），一个GE 3.0T磁体和一个空机架。除了现有的扫描仪外，新的BMRC还将采用下一代3.0 T西门子扫描仪。重新设计的BMRC最具创新性的特点是将一个小动物成像实验室（SAIL）整合到以前主要是人类成像中心。BMRC重新设计的总体目标是通过提供全面的转化研究基础设施来开发一个更自然的协作环境。SAIL除了MR成像套件外，还将包括一个动物处理套件，这是这项工作的使命。动物处理室将容纳一个小鼠和大鼠的卫星饲养室，以及一个动物准备实验室，配备用于进行显微手术的麻醉资源。动物成像室将包括控制室、成像室和电子支持室。安装“最先进的高场强（9.4或11.7T）小口径动物系统”的原始计划仅基于与场强成比例的信噪比（SNR）增益。过去一年中的两个重要事态发展使人们有理由改变这一立场。首先，是一种新技术的商业可用性，冷冻探针，产生显着的改善SNR，同时避免了混淆的物理现象的磁化率，介电效应，和T2* 缩短，随着场强的增加而恶化。此外，冷冻探针SNR的改善与场强呈负相关，在7T时SNR增加了3倍，在11.7 T时下降到1.5倍。第二个是位于哈佛医学院的老式4.7 T小口径动物扫描仪已经退役，导致一些用户呼吁留在7 T范围内。因此，我们提出了这一建议，以帮助收购一个7T 20厘米水平孔布鲁克系统与冷冻探针。除了有利于充满活力的动物成像计划，新的扫描仪将加强动物和人类研究人员之间的互动。例如，X核能力将允许对超极化气体进行成像。这是BWH独特的MRI项目之一，将利用BMRC中安装的超极化器。同样，新仪器将促进正在进行的小鼠心脏成像、小鼠前列腺成像、小儿猴功能成像和组织样本扩散张量成像研究。下一代产品将包括小鼠脑肿瘤和中风模型中的小鼠神经血管成像。 公共卫生关系：布里格姆磁共振成像研究中心（BMRC），位于尤金布劳恩沃尔德研究中心在221长木大道正在进行重大改造的结果，20国集团赠款。我们建议获得一台7T 20 cm小动物MRI扫描仪，以帮助促进BMRC成为最先进的翻译中心的总体目标。新仪器将支持现有的几个NIH资助的项目和研究人员，涵盖从心脏病学（肥大，遗传学），肺病学（超极化气体交换），前列腺成像到神经科学（扩散张量成像，脑肿瘤成像和中风成像）的范围。