INFANT PRIMATE RESEARCH LABORATORY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 在过去的拨款年度，实验室工作人员继续为正在进行的研究项目提供重要支持。服务包括咨询、培训、现场监督、设备维护和开发、规范和实验数据收集以及数据汇总和分析。在过去的一年里，实验室的翻新工作顺利完成。耗资1200万美元翻新的实验室包括首次连接IPRL两层的内部电梯，一个新的笼子垫圈，一个用于婴儿配方奶粉和食品准备的最先进厨房，更小的动物室，以更好地控制疾病爆发，新的游戏室，以及专门用于病毒研究的房间。翻修工程包括一间新的更衣室和为IPRL工作人员提供的卫生间和淋浴。除了提高猴子和人类饲养员的安全性外，这些物理设施还符合当前和预期的关于实验室饲养猴子环境浓缩的法规。 2010年，我们在生物行为评估方案的开发方面取得了进一步的进展。这些包括1)我们用于评估学习和记忆的触敏计算机化测试系统，2)主动收集视动和平滑追踪眼动数据的方案，3)评估听觉脑干反应的方法，以及4)研究自闭症相关工作中对各种刺激(面孔、抽象模式)的脑电反应的程序。所有的手术都是非侵入性的，仿照人类的婴儿期工作，并提供了在儿科健康研究方面取得重大进展的机会。此外，我们继续与众多研究人员合作，为实验室开展的项目提供健康的、已知怀孕的婴儿。我们还继续为对干细胞研究和婴儿神经行为发育感兴趣的实验室和联邦机构提供国家资源。我们广受欢迎的学生研究项目现在已经全面运作，计划包括一个关于灵长类发育和行为的月刊俱乐部(包括关于灵长类翻译研究的主题)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. During the past grant year, laboratory staff continued to provide vital support to on-going research projects. Services included consultation, training, on-site supervision, equipment maintenance and development, normative and experimental data collection and data summary and analysis. During the last year, the renovation of the lab was successfully completed. The 12 million dollar renovated lab includes an internal elevator connecting the 2 floors of the IPRL for the first time, a new cage washer, a state-of-the-art kitchen for infant formula and food preparation, smaller animal rooms to better control disease outbreaks, new playrooms, and specialized rooms for virus studies. A new locker room and bathrooms and showers for IPRL staff were included in the renovation. In addition to improving safety for both monkeys and human handlers, the physical facilities also meet current and anticipated regulations regarding environmental enrichment for laboratory-housed monkeys. During 2010, we made further advances in the development of biobehavioral assessment protocols. These include1) our touch-sensitive computerized testing system for the assessment of learning and memory, 2) protocols to actively collect optokinetic and smooth pursuit eye movement data, 3) methods to evaluate the auditory brainstem response and 4) procedures to study EEG responses to a variety of stimuli (faces, abstract patterns) in autism-related work. All procedures are noninvasive, modeled from human infancy work and provide the opportunity to make strong advances in pediatric health research. In addition, we continue to work with a myriad of investigators to provide healthy, gestation-known infants for projects conducted in the lab. We also continue to serve as a national resource for laboratories and federal agencies interested in stem cell research and infant neurobehavioral development. Our popular student research program is now fully operational with plans to include a monthly journal club on Primate Development and Behavior (including topics on primate translational research).