INFANT PRIMATE RESEARCH LAB (IPRL)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在过去的一个赠款年度，IPRL取得了一些显着的科学和技术成就。 胚胎干细胞（ESC）系是从两种猕猴中开发出来的。 到目前为止，已经建立了超过15个单独的细胞系，并且已经冷冻保存了这些细胞系在不同培养阶段的750多个样品。 还开发了来自分裂胚的ESC系。 在过去的一年里，IPRL的主要努力之一是继续使用计算机化触摸屏测试系统开发认知测试。在IPRL开发的系统可以成功地用于90天大的婴儿。 为了实现我们为研究者提供创新测试方法的目标，我们成功地与来自儿童医院和地区医疗中心以及耳鼻喉科的研究者团队（Jim菲利普斯和Avery韦斯博士）合作，开发了研究婴儿灵长类动物眼功能发育的测试程序。 IPRL现在可以为研究者提供幼猴视动和平滑追踪眼动数据的纵向收集。 跟踪眼球运动的新测试设备已捐赠给IPRL，目前正在组装中。 儿童地区医院和医疗中心使用相同的刺激和监测工具来收集人类婴儿的数据。我们继续升级数据收集和管理程序，现在所有神经行为数据都通过戴尔笔记本电脑和/或掌上设备（如Palm Pilots）收集。 我们继续拥有一个繁荣的繁殖群体，为实验室进行的项目生产健康的、已知妊娠的婴儿。 最后，伯巴赫、萨基特和格兰特博士出版了一本名为《儿童健康和发育障碍的灵长类动物模型》（Elsevier，2008）的书，强调了灵长类动物模型在当代儿科研究中的优势。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the past grant year, there have been a number of notable scientific and technological achievements in the IPRL. Embryonic stem cell (ESC) lines were developed from two species of macaque monkeys. To date, more than 15 individual cell lines have been created and more than 750 samples of these lines at various stages of culture have been cryopreserved. ESC lines from split embryos have also been developed. One of the major efforts in the IPRL during the last year has been to continue developing cognitive tests using a computerized touch-screen testing system. The system developed at the IPRL can be successfully used with infants as young as 90-days of age. To meet our goal of providing investigators with innovative test methods, we have successfully worked with a team of investigators from Children's Hospital and Regional Medical Center and the Dept of Otolaryngology (Drs. Jim Phillips and Avery Weiss) to develop test procedures to study the development of oculomotor function in infant primates. The IPRL can now offer the longitudinal collection of optokinetic and smooth pursuit eye movement data in infant monkeys to investigators. New test equipment to track eye movements has been donated to the IPRL and is currently being assembled. Identical stimuli and monitoring tools are used at Children's Regional Hospital and Medical Center to collect data on human infants. Upgrades of our data collection and management programs have continued and all neurobehavioral data are now collected via DELL laptops and or/hand-held devices such as Palm Pilots. We continue to have a thriving breeding colony to produce healthy, gestation-known infants for projects conducted in the lab. Lastly, Drs. Burbacher, Sackett and Grant published a book titled "Primate Models of Children's Health and Developmental Disabilities" (Elsevier, 2008) to highlight the strengths of the primate model in contemporary pediatric research.