Animal Behavior Core

项目摘要-动物行为核心 动物行为核心(ABC)为调查人员提供了一个基础设施，以执行最 对啮齿动物模型进行先进和创新的功能评估，以帮助理解动物的起源和 智力和发育障碍(IDD)的治疗。美国农业部支持旨在发展 以及对基因鉴定或基因修饰研究产生的新的IDD啮齿动物模型进行表征 或由IDDRC研究附属机构进行的环境暴露研究。此外，ABC是至关重要的，因为 IDDRC调查人员评估内在的(基于基因的)和/或外在的(外科， 环境、化学或药物)干预。ABC的具体目标是：1.提供科学的、 为研究附属机构提供管理和预算服务，使用动物模型进行IDD研究； 2.为调查人员提供行为测试设备、研究空间和新颖的测试方案 在IDD的啮齿动物模型中实现最先进的行为评估；3.培训研究附属机构及其 具有适当测试协议的工作人员；4.协调其他IDDRC核心和支持的服务 临床应用的开发；以及5.促进开发更多的创新技术 可与IDD啮齿动物模型的行为功能评估结合使用。

PROJECT SUMMARY – ANIMAL BEHAVIOR CORE The Animal Behavior Core (ABC) provides an infrastructure for investigators to perform the most advanced and innovative functional assessments in rodent models to assist in understanding the origins and treatment of intellectual and developmental disabilities (IDD). The ABC supports efforts aimed at developing and characterizing novel rodent models of IDD that result from gene identification or gene modification research or environmental exposure studies performed by IDDRC Research Affiliates. Furthermore, the ABC is critical as IDDRC investigators evaluate the functional outcomes of intrinsic (gene-based) and/or extrinsic (surgical, environmental, chemical, or drug-based) interventions. Specific Aims of the ABC are: 1. Provide scientific, management, and budgeting services to Research Affiliates using animal models for studies of IDD; 2. Provide behavioral testing equipment, research space, and novel testing protocols for investigators that enable state-of-the-art assessment of behavior in rodent models of IDD; 3. Train Research Affiliates and their staff in appropriate testing protocols; 4. Coordinate services across other IDDRC Cores and support development of clinical applications; and 5. Promote the development of additional innovative techniques that can be utilized in conjunction with assessments of behavioral functions in rodent models of IDD.