PRE-CLINICAL TRIALS FOR FEMALE FERTILITY PRESERVATION
PRE-CLINICAL TRIALS FOR FEMALE FERTILITY PRESERVATION
批准号:
8357745
负责人:
Mary B Zelinski
金额:
$3.63万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-05-01 至 2012-04-30
关键词:
2 year oldAdverse effectsAgonistApoptoticBiological PreservationCancer PatientCeramidesEmbryonic DevelopmentFailureFemaleFertilityFertilizationFundingGenerationsGenomicsGonadal structureGrantHumanInfertilityLifeMacacaMacaca mulattaMusNational Center for Research ResourcesOocytesOvarianOvaryPartner in relationshipPrimatesPrincipal InvestigatorPubertyRadiationRadiation induced damageRadiation therapyResearchResearch InfrastructureResourcesSafetySourceStressTechnologyUnited States National Institutes of HealthValidationcancer therapycostin vivoirradiationmeetingsneoplastic celloffspringpreclinical studypreventsensorsphingosine 1-phosphatesuccess
中文摘要
这个子项目是利用这些资源的众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
Early ovarian failure and infertility are well-known side effects of anti-cancer treatments. Attempts to preserve fertility and ovarian function in female cancer patients have met with little success. In mice, sphingosine-1-phosphate (S1P), a metabolite of the pro-apoptotic stress sensor ceramide, protects the ovaries from radiation-induced damage in vivo, preserves a normal level of fertility, and offspring conceived with oocytes protected from radiation by S1P show no evidence of transgenerational genomic damage. The safety and efficacy of S1P for preserving ovarian function and fertility in primates exposed to anti-cancer treatments needs to be established. Technologies to deliver S1P only to the ovaries, thereby preventing systemic availability of S1P that could benefit the tumor cells targeted for destruction, also requires validation. The specific aims are 1) to determine if S1P can be administered directly into the rhesus monkey ovary to protect the gonads from radiotherapy-induced damage in vivo; 2) to evaluate the competency of macaque oocytes protected from radiotherapy by S1P for fertilization and embryogenesis; and 3) to assess if offspring conceived from macaque oocytes protected from radiotherapy by S1P in vivo show evidence of propagated genomic damage. Five live, normal offspring were derived from S1P agonist-treated females who received ovarian X-irradiation. They are now 1-2 years old and will be maintained until puberty and then mated to assess whether the second generation is free from genomic damage. Thus, S1P has potential as a safe and effective strategy for protecting human ovaries from the damage caused by anti-cancer therapies, and prevent infertility.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Cryopreservation and Transplantation of Ovarian Cortical Tissue for Fertility Preservation
-
批准号:9920744
-
项目类别:
-
资助金额:$58.81万
-
财政年份:2016
-
负责人:Mary B Zelinski
-
依托单位:
Cryopreservation and Transplantation of Ovarian Cortical Tissue for Fertility Preservation
-
批准号:9288194
-
项目类别:
-
资助金额:$62.72万
-
财政年份:2016
-
负责人:Mary B Zelinski
-
依托单位:
ONCOFERTILITY SATURDAY ACADEMY
-
批准号:8357884
-
项目类别:
-
资助金额:$3.63万
-
财政年份:2011
-
负责人:Mary B Zelinski
-
依托单位:
IMPACT OF MATERNAL HIGH FAT DIET ON OFFSPRING OVARIAN FUNCTION
-
批准号:8357852
-
项目类别:
-
资助金额:$3.63万
-
财政年份:2011
-
负责人:Mary B Zelinski
-
依托单位:
ROLE OF STRESS IN PCOS: NEURONAL MECHANISMS
-
批准号:8357853
-
项目类别:
-
资助金额:$3.63万
-
财政年份:2011
-
负责人:Mary B Zelinski
-
依托单位:
GENE EXPRESSION IN 3D FOLLICLES
-
批准号:8357851
-
项目类别:
-
资助金额:$4.36万
-
财政年份:2011
-
负责人:Mary B Zelinski
-
依托单位:
AMH AS PREDICTOR OF FOLLICLE FUNCTION DURING ENCAPSULATED 3D CULTURE IN MACAQUES
-
批准号:8357774
-
项目类别:
-
资助金额:$1.82万
-
财政年份:2011
-
负责人:Mary B Zelinski
-
依托单位:
OVARIAN TISSUE CRYOPRESERVATION IN NONHUMAN PRIMATES
-
批准号:8357823
-
项目类别:
-
资助金额:$5.82万
-
财政年份:2011
-
负责人:Mary B Zelinski
-
依托单位:
AMH AS PREDICTOR OF FOLLICLE FUNCTION DURING ENCAPSULATED 3D CULTURE IN MACAQUES
-
批准号:8173239
-
项目类别:
-
资助金额:$4.76万
-
财政年份:2010
-
负责人:Mary B Zelinski
-
依托单位:
PRE-CLINICAL TRIALS FOR FEMALE FERTILITY PRESERVATION
-
批准号:8173193
-
项目类别:
-
资助金额:$4.76万
-
财政年份:2010
-
负责人:Mary B Zelinski
-
依托单位:
OVARIAN TISSUE CRYOPRESERVATION IN NONHUMAN PRIMATES
-
批准号:8173321
-
项目类别:
-
资助金额:$7.61万
-
财政年份:2010
-
负责人:Mary B Zelinski
-
依托单位:
NOVEL REGIMEN FOR CONTROLLED OVARIAN STIMULATION IN MACAQUES
-
批准号:7958443
-
项目类别:
-
资助金额:$8.03万
-
财政年份:2009
-
负责人:Mary B Zelinski
-
依托单位:
PRE-CLINICAL TRIALS FOR FEMALE FERTILITY PRESERVATION
-
批准号:7958428
-
项目类别:
-
资助金额:$8.03万
-
财政年份:2009
-
负责人:Mary B Zelinski
-
依托单位:
ASSESSING OVARIAN RESERVE AFTER FOLLICULAR PROTECTION PRIOR TO X-IRRADIATION
-
批准号:7958497
-
项目类别:
-
资助金额:$5.02万
-
财政年份:2009
-
负责人:Mary B Zelinski
-
依托单位:
PRE-CLINICAL TRIALS FOR FEMALE FERTILITY PRESERVATION
-
批准号:7715898
-
项目类别:
-
资助金额:$5.55万
-
财政年份:2008
-
负责人:Mary B Zelinski
-
依托单位:
ASSESSING OVARIAN RESERVE AFTER FOLLICULAR PROTECTION PRIOR TO X-IRRADIATION
-
批准号:7715992
-
项目类别:
-
资助金额:$2.77万
-
财政年份:2008
-
负责人:Mary B Zelinski
-
依托单位:
NOVEL REGIMEN FOR CONTROLLED OVARIAN STIMULATION IN MACAQUES
-
批准号:7715921
-
项目类别:
-
资助金额:$5.55万
-
财政年份:2008
-
负责人:Mary B Zelinski
-
依托单位:
Nonhuman Primate Contraceptive Core
-
批准号:8400523
-
项目类别:
-
资助金额:$38.88万
-
财政年份:2007
-
负责人:Mary B Zelinski
-
依托单位:
PRE-CLINICAL TRIALS FOR FEMALE FERTILITY PRESERVATIONS
-
批准号:7561903
-
项目类别:
-
资助金额:$7.59万
-
财政年份:2007
-
负责人:Mary B Zelinski
-
依托单位:
NOVEL REGIMEN FOR CONTROLLED OVARIAN STIMULATION IN MACAQUES
-
批准号:7561936
-
项目类别:
-
资助金额:$1.47万
-
财政年份:2007
-
负责人:Mary B Zelinski
-
依托单位:
海外基金