IMPACT OF MATERNAL HIGH FAT DIET ON OFFSPRING OVARIAN FUNCTION

母亲高脂肪饮食对后代卵巢功能的影响

基本信息

  • 批准号:
    8357852
  • 负责人:
  • 金额:
    $ 3.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-05-01 至 2012-04-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. A dramatic increase in childhood obesity and diabetes is currently evident. While mainly attributed to calorically dense diets and a lack of activity, another contributing factor is maternal health and diet during pregnancy and the early neonatal period. Both intrauterine and neonatal environments contribute to metabolic abnormalities in offspring of rodents and sheep. Children born to diabetic women have abnormal adiposity, are insulin resistant, and have increased risk of developing early onset obesity. While numerous reports detail detrimental effects on reproductive function in offspring of mothers fed calorie-restricted diets during pregnancy, the direct impact of maternal obesity on reproductive function of female offspring is rarely studied. Obese adolescent girls are at increased risk for developing polycystic ovarian syndrome, a common form of infertility. There are no controlled studies in women and their female children relating the mother's diet during pregnancy to the child's propensity for reproductive anomalies either prior to or at puberty. There are also no ovarian specimens to examine from children due to ethical considerations. We preserved ovaries from adult female macaques fed control, or high fat diets, as well as female fetuses (gestational day 130) and female juvenile macaques derived from mothers fed control or high fat diets during pregnancy. Ovarian morphology and immunocytochemical markers of proliferation, apoptosis, vascularity, inflammation and oocyte integrity are being analyzed. These studies will determine the impact of maternal high fat diet on ovarian function of offspring in primates, and whether effects can be observed during fetal development and/or prior to puberty.
这个子项目是利用这些资源的众多研究子项目之一

项目成果

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Mary B Zelinski其他文献

Mary B Zelinski的其他文献

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{{ truncateString('Mary B Zelinski', 18)}}的其他基金

Cryopreservation and Transplantation of Ovarian Cortical Tissue for Fertility Preservation
卵巢皮质组织的冷冻保存和移植以保存生育能力
  • 批准号:
    9920744
  • 财政年份:
    2016
  • 资助金额:
    $ 3.63万
  • 项目类别:
Cryopreservation and Transplantation of Ovarian Cortical Tissue for Fertility Preservation
卵巢皮质组织的冷冻保存和移植以保存生育能力
  • 批准号:
    9288194
  • 财政年份:
    2016
  • 资助金额:
    $ 3.63万
  • 项目类别:
ONCOFERTILITY SATURDAY ACADEMY
周六生育力学院
  • 批准号:
    8357884
  • 财政年份:
    2011
  • 资助金额:
    $ 3.63万
  • 项目类别:
PRE-CLINICAL TRIALS FOR FEMALE FERTILITY PRESERVATION
女性生育力保存的临床前试验
  • 批准号:
    8357745
  • 财政年份:
    2011
  • 资助金额:
    $ 3.63万
  • 项目类别:
ROLE OF STRESS IN PCOS: NEURONAL MECHANISMS
压力在多囊卵巢综合症中的作用:神经机制
  • 批准号:
    8357853
  • 财政年份:
    2011
  • 资助金额:
    $ 3.63万
  • 项目类别:
GENE EXPRESSION IN 3D FOLLICLES
3D 卵泡中的基因表达
  • 批准号:
    8357851
  • 财政年份:
    2011
  • 资助金额:
    $ 3.63万
  • 项目类别:
AMH AS PREDICTOR OF FOLLICLE FUNCTION DURING ENCAPSULATED 3D CULTURE IN MACAQUES
AMH 作为猕猴封装 3D 培养期间卵泡功能的预测因子
  • 批准号:
    8357774
  • 财政年份:
    2011
  • 资助金额:
    $ 3.63万
  • 项目类别:
OVARIAN TISSUE CRYOPRESERVATION IN NONHUMAN PRIMATES
非人类灵长类动物的卵巢组织冷冻保存
  • 批准号:
    8357823
  • 财政年份:
    2011
  • 资助金额:
    $ 3.63万
  • 项目类别:
AMH AS PREDICTOR OF FOLLICLE FUNCTION DURING ENCAPSULATED 3D CULTURE IN MACAQUES
AMH 作为猕猴封装 3D 培养期间卵泡功能的预测因子
  • 批准号:
    8173239
  • 财政年份:
    2010
  • 资助金额:
    $ 3.63万
  • 项目类别:
PRE-CLINICAL TRIALS FOR FEMALE FERTILITY PRESERVATION
女性生育力保存的临床前试验
  • 批准号:
    8173193
  • 财政年份:
    2010
  • 资助金额:
    $ 3.63万
  • 项目类别:

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