FACTORS UNDERLYING AGGRESSIVE BEHAVIOR IN MACAQUES

猕猴攻击行为的潜在因素

• 批准号: 7715949
• 负责人: Kristine Coleman
• 金额: $ 2.77万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715949
• 关键词: Aggressive behavior; Animals; Behavior; Behavioral; Computer Retrieval of Information on Scientific Projects Database; Environmental Risk Factor; Fibrinogen; Funding; Genes; Genetic; Genotype; Goals; Grant; Human; Impulsive Behavior; Institution; Japanese Population; Life; Macaca; Modeling; Monoamine Oxidase A; Outcome; Physiological; Play; Rate; Research; Research Personnel; Resources; Role; Serotonin; Source; System; United States National Institutes of Health; Violence; Work; behavior influence; nonhuman primate; serotonin transporter; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. As rates of violent behavior rise, more work is focusing on physiological and genetic underpinnings of aggression and associated traits. One factor that was associated with aggression is the serotonergic system. Serotonin deficiencies have been found to correlate with increased rates of aggression and related traits, such as impulsive behavior in humans and other animals. One gene found to regulate serotonin is the serotonin transporter gene (5-HTT). A second gene that serves to regulate serotonin, and may also play a role in aggression, is monoamine oxidase A (MAO A). While there is considerable evidence supporting the association between these genes and aggressive behavior, other studies failed to replicate these findings. Alternatively, nonhuman primates may provide an excellent model for examining the role that these genes may play in the expression of aggression and related behaviors, as well as identifying environmental factors that may interact with genotype to influence behavioral outcome. The main goal of the project is to examine behavioral and physiological correlates to aggression in a group of semi-free living Japanese macaques.

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