MICROGLIA AND SIV NEUROPATHOGENESIS

小胶质细胞和 SIV 神经发病机制

• 批准号: 8358052
• 负责人: Xavier Alvarez-Hernandez
• 金额: $ 5.78万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358052
• 关键词: Blood - brain barrier anatomy; Blood Circulation; Blood Vessels; Brain; Cells; Cerebrum; Funding; Grant; HIV; Human; Immune system; Mediating; Meninges; Microglia; National Center for Research Resources; Nervous system structure; Neuraxis; Neuronal Injury; Neuropathogenesis; Pathogenesis; Play; Population; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Role; SIV; Source; Structure of choroid plexus; United States National Institutes of Health; cost; macrophage; monocyte; nonhuman primate; trafficking

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Located in the perivascular space of cerebral microvessels, perivascular macrophages are uniquely situated at the interface between brain parenchyma and blood vessels. Connections between the nervous and immune systems are mediated in part through these cells that are ideally located to sense perturbations in the periphery and are turn over by cells entering the CNS from the circulation. It has become clear that unique subsets of brain macrophage exist in normal and SIV and HIV infected brain, and perivascular macrophages and cells similar to perivascular macrophages in the meninges and choroids plexus play a central role in lentiviral pathogenesis. Common to all these cell populations is their replacement within the CNS by monocytes. Studies of SIV infected non human primates and HIV infected humans underscore the importance of HIV-infected and/or activated monocytes, which traffic to the central nervous system (CNS) the potentially drive the blood-brain barrier damage and may cause neuronal injury.

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