NEURAL SUBSTRATES OF AGE-RELATED COGNITIVE DECLINE IN MONKEYS

猴子与年龄相关的认知衰退的神经基础

• 批准号: 8357922
• 负责人: Douglas L Rosene
• 金额: $ 5.4万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357922
• 关键词: 15 year old; 20 year old; Age; Age-associated memory impairment; Aging; Behavior assessment; Biological Preservation; Blood specimen; Brain; Cognitive; Data; Female; Funding; Goals; Grant; Human; Impaired cognition; Inflammation; MRI Scans; Macaca mulatta; Modeling; Monkeys; National Center for Research Resources; Neurons; New England; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Sampling; Source; Testing; Therapeutic Intervention; Tissue Sample; United States National Institutes of Health; base; brain tissue; cost; design; middle age; relating to nervous system; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Neural Substrates of Age-related Cognitive Decline in Monkeys The rhesus monkey is a model of normal human aging that allows cognitive testing to be followed by optimal preservation of brain tissue for study. This projects tests the hypothesis that age-related cognitive decline results from a cascade of mild degenerative changes beginning with inflammation in white matter followed by functional and then structural changes in neurons. This is a longitudinal project that follows a group of 12 middle aged female rhesus monkeys for five years beginning between 13 and 15 years of age. Regular behavioral assessment is conducted to identify the rate of age-related cognitive decline and to determine how this differs among subjects in order to differentiate between monkeys that age "successfully" and those that are relatively "unsuccessful". Regular MRI scans, blood samples and CSF samples are collected to assess different markers of aging. At the end of five years the brain tissue samples will be used to identify changes responsible for cognitive decline. As the degree of cognitive impairment is mild at 13 - 15 but high by 18 - 20 years of age, these data will allow us to identify brain changes associated with the rate of cognitive decline with the goal of designing therapeutic interventions aimed at slowing or reversing cognitive decline.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 猴脑相关性认知功能减退的神经基础 恒河猴是人类正常衰老的模型，允许认知测试之后进行最佳的脑组织保存以供研究。该项目测试了以下假设：年龄相关的认知能力下降是由一系列轻度退行性变化引起的，这些变化始于白色物质中的炎症，然后是神经元中的功能变化和结构变化。这是一个纵向项目，跟踪一组12只中年雌性恒河猴，从13岁到15岁开始，为期5年。定期进行行为评估，以确定与年龄相关的认知能力下降的速度，并确定受试者之间的差异，以区分“成功”衰老的猴子和相对“不成功”衰老的猴子。定期进行MRI扫描，收集血液样本和CSF样本，以评估不同的衰老标志物。在五年结束时，脑组织样本将用于识别导致认知能力下降的变化。由于认知障碍的程度在13 - 15岁时是轻度的，但在18 - 20岁时是高的，这些数据将使我们能够确定与认知下降速度相关的大脑变化，目的是设计旨在减缓或逆转认知下降的治疗干预措施。