GENE/DIET EFFECTS ON PLASMA LIPOPROTEIN LEVELS

描述：冠心病仍然是主要原因之一， 美国的发病率和死亡率。 疾病程度的预测因素。 优化饮食建议 血浆脂质谱包括减少总膳食脂肪、饱和脂肪 和胆固醇 然而，个人对饮食的反应表明， 是血清脂蛋白对饮食反应一个强有力的遗传成分 操纵 私家侦探和他的研究团队，以及其他 研究人员已经表明，几个候选基因的多态性 与脂质代谢相关的饮食反应增加 干预研究。 这些候选基因包括apoA-I、apoB、apoE 以及apoC-III和apoA-IV。 本提案的目标是：1）确定 六个候选基因位点的九种遗传变异对禁食的影响 血浆总、LDL、HDL-胆固醇和甘油三酯浓度 存活人口（Fragrance Offspring，n= 3，600和OMNI，n= 1，200 非洲裔美国人和西班牙裔队列）及其饮食调节 习惯，年龄，性别和其他环境变量; 2）确定 这些位点遗传变异对个体血脂影响 自由生活中饮食习惯的改变 人口

DESCRIPTION: Coronary heart disease remains one of the primary causes of morbidity and mortality in the U.S. Plasma lipid concentrations are strong predictors of the extent of disease. Dietary recommendations to optimize plasma lipid profiles include reductions of total dietary fat, saturated fat and cholesterol. However, individual responses to diet suggest that there is a strong genetic component to serum lipoprotein response to dietary manipulation. The P.I. and his research team, as well as other investigators, have shown that polymorphisms in several candidate genes related to lipid metabolism are associated with increased dietary response to intervention studies. These candidate genes include apoA-I, apoB, apoE and apoC-III and apoA-IV. The goals of this proposal are to: 1) determine the effects of nine genetic variants at six candidate gene loci on fasting plasma total, LDL, HDL-cholesterol and triglyceride concentrations in a free living population (Framingham Offspring, n=3,600 and OMNI, n=1,200 African-American and Hispanic Cohorts) and their modulation by dietary habits, age, gender and other environmental variables; and 2) determine the effect of genetic variability at these loci on individual plasma lipid changes resulting from modification of dietary habits in a free living population.