Epigenetics: Opportunities for Sleep and Circadian Research

表观遗传学：睡眠和昼夜节律研究的机会

• 批准号: 8399335
• 负责人: Allan I Pack
• 金额: $ 4.9万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8399335
• 关键词: Address; Adult; Aging; Aging-Related Process; Angelman Syndrome; Applications Grants; Area; Award; Brain; Cardiovascular system; Circadian Rhythms; Collaborations; Communities; DNA Methylation; DNA Sequence; Data; Development; Developmental Process; Disease; Educational workshop; Epigenetic Process; Etiology; Fragile X Syndrome; Gene Expression; Health; Institutes; Journals; Link; Longevity; Malignant Neoplasms; Mental disorders; Metabolic Diseases; Metabolic syndrome; Metabolism; Methodology; National Institute on Aging; Nerve Degeneration; Nervous system structure; Neurodevelopmental Disorder; Neurologic; Neuronal Plasticity; Obesity; Oral; Pathogenesis; Philadelphia; Play; Process; Publishing; RNA Interference; Recommendation; Research; Research Personnel; Research Priority; Rett Syndrome; Role; Sleep; Sleep Disorders; Slide; Strategic Planning; Students; Synaptic plasticity; Techniques; Travel; United States National Institutes of Health; Variant; chromatin remodeling; circadian pacemaker; design; developmental disease; epigenomics; histone modification; interest; nervous system disorder; programs; relating to nervous system; research study; sleep regulation; suburb; symposium; web site

DESCRIPTION (provided by applicant): Epigenetics is rapidly evolving as an important area of inquiry. There are already data that epigenetic mechanisms play an important role in linking metabolism to the functioning of the circadian clock. Currently, however, there is very limited information as to the role of epigenetics in regulation of sleep and in the pathogenesis of sleep disorders. This conference proposal is designed to address this void. The conference title is "Epigenetics: Opportunities for Sleep and Circadian Research". It is proposed to bring together investigators from sleep and circadian research and from epigenetics. The conference is designed to bring investigators in sleep/circadian research up to date with epigenetic concepts and techniques. Further, it is constructed in such a way that investigators in epigenetics will become familiar with current concepts and questions in sleep/circadian research and study of sleep disorders. The conference is designed to stimulate future research collaborations between these two scientific communities and to excite new investigators in getting involved in this area. The conference has initial overview sessions to familiarize epigenetic investigators about sleep and sleep disorders and then investigators in sleep/circadian research about epigenetics. Thereafter there are multiple sessions each on a specific topic with investigators presenting from the sleep/circadian background and from epigenetics. The specific topic areas are as follows: a) Synaptic Plasticity: Sleep & Epigenomics; b) Aging & Neurodegeneration; c) Metabolism, Sleep & Epigenomics; d) Psychiatric & Neurodevelopmental Disorders; and e) Techniques. Travel awards will also be provided to new investigators and a specific session on the program will be for relevant oral presentations from new investigators. A workshop summary of the conference will be published in the leading sleep research journal, Sleep. This will contain information about the website, which will have slides from all presenters; thus, talks will be available to anybody interested on this website. The topic of the conference is timely since it is one of the new areas of inquiry proposed in the recently announced NIH Strategic Plan for Sleep Disorders Research, as well as research priorities within the National Institute on Aging. PUBLIC HEALTH RELEVANCE: A two and 1/2 day conference to identify research opportunities to further elucidate epigenetic mechanisms in sleep processes and leading to sleep disorders will be held on October 3-5, 2012 in Lafayette Hills, PA, a suburb of Philadelphia. This conference grant application to the National Institute on Aging, with support from other Institutes, requests partial support for the conference that will be used primarily to cover the travel and hotel expenses of the invited speakers and student awards.

描述（由申请人提供）：表观遗传学作为一个重要的研究领域正在迅速发展。已有数据表明，表观遗传机制在将新陈代谢与生物钟功能联系起来方面发挥着重要作用。然而，目前，关于表观遗传学在调节睡眠和睡眠障碍发病机制中的作用的信息非常有限。本次会议提案旨在解决这一空白。会议的题目是“表观遗传学：睡眠和昼夜节律研究的机会”。建议将来自睡眠和昼夜节律研究以及表观遗传学的研究人员聚集在一起。会议旨在为睡眠/昼夜节律研究人员带来最新的表观遗传学概念和技术。此外，它是以这样一种方式构建的，即表观遗传学的研究者将熟悉睡眠/昼夜节律研究和睡眠障碍研究中的当前概念和问题。这次会议旨在促进这两个科学团体之间未来的研究合作，并激发新的研究人员参与这一领域。会议有初步的概述会议，让表观遗传学研究人员熟悉睡眠和睡眠障碍，然后研究人员在睡眠/昼夜节律研究表观遗传学。此后有多个会议，每个会议都有研究人员从睡眠/昼夜节律背景和表观遗传学方面介绍一个特定的主题。具体主题领域如下：a)突触可塑性：睡眠与表观基因组学；b)衰老与神经变性；c)代谢、睡眠与表观基因组学；d)精神和神经发育障碍；e)技术。还将为新研究者提供旅行奖励，并在该项目中为新研究者提供相关的口头报告。会议的研讨会总结将发表在领先的睡眠研究杂志《睡眠》上。这将包含