SWAN NJ-Quantitative and Qualitative cohort Research

SWAN NJ-定量和定性队列研究

• 批准号: 8300839
• 负责人: CAROL A. DERBY
• 金额: $ 37.71万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8300839
• 关键词: Accounting; Address; Adverse reactions; Alternative Medicine; Androstenedione; Area; Atherosclerosis; Blood; Body Weight; Calories; Clinical; Clinical Research; Cognition; Complementary and alternative medicine; Data; Degenerative polyarthritis; Development; Diabetes Mellitus; Diet; Distress; Energy Intake; Equilibrium; Estrone; Ethnic Origin; Ethnic group; Food; Fracture; Frequencies; Gait; Happiness; Health; Hispanics; Hormonal; Hormones; Instruction; Interview; Life; Major Depressive Disorder; Maps; Measurement; Medical; Menopausal Symptom; Menopause; Metabolic; Metabolic syndrome; N-formylmethionylphenylalanine; New Jersey; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Participant; Pattern; Performance; Physical Function; Population; Prevalence; Principal Investigator; Protein Isoforms; Qualitative Methods; Qualitative Research; Quality of life; Questionnaires; Race; Recruitment Activity; Reporting; Research; Resolution; Rest; Risk Factors; SHBG gene; Severities; Sex Functioning; Site; Sleep; Stress; Surveys; Symptoms; Testing; Time; United States; Vagina; Vasomotor; Weight Gain; Woman; Women' s Health; base; bone; cardiovascular risk factor; cohort; coping; coping mechanism; diabetes risk; ethnic minority population; experience; follow-up; hormone therapy; inflammatory marker; low socioeconomic status; member; middle age; programs; satisfaction

Program Director/Principal Investigator (Last, First, Middle): SantOrO, Nanette PROJECT SUMMARY (See instructions): SWAN, the Study of Women's Health Across the Nation, is a multi-ethnic, multi-site study of mid life women in the United States that has been active for over 10 years. The SWAN-New Jersey cohort had the lowest socio-economic status, the poorest health indicators at baseline and has suffered from substantialloss to follow up and impediments to continued research. Despite substantial attrition, SWAN-New Jersey Hispanic women continue to have the highest rate of incident metabolic syndrome and type 2 diabetes, and report more symptoms with more adverse reactions to their symptoms over the menopause transition compared to the rest of the SWAN cohort. We have also recognized the need to better understand key discrepancies between our data on Hispanic women and the rest of the cohort with respect to the use of complementary and alternativemedicineand the reporting of total daily caloric intake. We thus propose 3 specific aims that will focus exclusively on the remaining Hispanic cohort members (n=150) and seek to integrate quantitative and qualitative methods of inquiriy: Aim 1 will continue to collect quantitative data;physical measurements, blood and abbreviated survey data and SCID interviewson our Hispanic cohort members to address as may overall SWAN FVhypotheses as are feasible and to test specificallythe hypothesies that Hispanic women will be more likely to: a. acquire metabolic syndrome and diabetes; b. report more vasomotor symptoms and experience greater distress from them yet seek medical treatment less frequently than other ethnic groups in SWAN . Aim 2 will examine discrepancies between the Hispaniccohort and the rest of SWAN to test the hypotheses that Hispanic women: a. do not view menopause as a medical conditionthat requires treatment; b. utlize more CAM treatment than believed due to lack of ethnically appropriate survey use and c. under-reported calories consumed due to a lack of ethnically appropriate food choices on the surveys used. Aim 3 will explore attitudesand benefits associated with menopause, investigate the conceptual perspective through which women experience menopausal symptoms, and investigate and examine what coping mechanisms and practices are utilized such as CAM and diet through the use of narrative interviews (qualitative research) with Hispanic women. RELEVANCE fSee instructions): The combination of quantitative and qualitative approaches is intended to maximize the information that can be obtained from a difficult-to-recruit and retain population of women for whom retention has been a challenge, and will serve to inform future research dedicated to study of a mixed group of Hispanic women. These findings can be applied to the challenges involved in conducting clinical research in ethnic minorities. PROJECT/

项目总监/首席研究员（最后、第一、中间）：SantOrO、Nanette 项目摘要（参见说明）： SWAN（全国妇女健康研究）是一项针对美国中年妇女的多种族、多地点研究 美国已经活跃了10多年。 SWAN-新泽西队列的社会经济地位最低 状况，基线健康指标最差，并遭受了后续行动的重大损失和障碍 继续研究。尽管人员流失严重，SWAN-新泽西州西班牙裔女性的比例仍然最高 代谢综合征和 2 型糖尿病的发生率，并报告更多的症状和更多的不良反应 与 SWAN 队列中的其他人相比，更年期过渡期间的症状。我们也认识到了这个需求 更好地了解我们的西班牙裔女性数据与其他群体的数据之间的关键差异 补充和替代药物的使用以及每日总热量摄入的报告。因此我们建议3 具体目标将专门关注剩余的西班牙裔群体成员（n = 150）并寻求融入 定量和定性调查方法：目标 1 将继续收集定量数据；物理数据 对我们的西班牙裔队列成员进行测量、血液和简短调查数据以及 SCID 访谈，以解决以下问题： 可能总体上 SWAN FV 假设是可行的，并具体检验西班牙裔女性将成为的假设 更有可能：获得代谢综合征和糖尿病； b.报告更多的血管舒缩症状并经历更多 与 SWAN 的其他族裔群体相比，他们虽然遭受痛苦，但寻求医疗的频率却较低。目标 2 将检查 西班牙裔群体与 SWAN 的其他群体之间的差异，以检验西班牙裔女性的假设：不要 将更年期视为一种需要治疗的疾病； b.由于缺乏而使用的 CAM 治疗比想象的要多 适合种族的调查使用和 c．由于缺乏适合种族的卡路里消耗量报告不足 所用调查的食物选择。目标 3 将探讨与更年期相关的态度和益处，调查 女性经历更年期症状的概念视角，并调查和检查什么 通过叙述性访谈（定性访谈）来利用应对机制和实践，例如 CAM 和饮食 研究）与西班牙裔女性。 相关性 f 请参阅说明）： 定量和定性方法的结合旨在最大限度地利用可 是从难以招募和留住女性群体中获得的，对她们来说，留住她们是一个很重要的问题 挑战，并将为未来致力于研究西班牙裔女性混合群体的研究提供信息。 这些发现可以应用于应对少数民族临床研究所面临的挑战。 项目/