CVD TRENDS 1980 TO 1991--A GENDER SPECIFIC PERSPECTIVE

1980 年至 1991 年 CVD 趋势——特定性别的视角

• 批准号: 2445327
• 负责人: CAROL A. DERBY
• 金额: $ 5.8万
• 依托单位: MEMORIAL HOSPITAL OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 1997-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2445327
• 关键词: cardiovascular disorder epidemiology; clinical research; coronary disorder; data collection methodology /evaluation; disease /disorder proneness /risk; gender difference; human data; human morbidity; human mortality; stroke

DESCRIPTION: (Adapted from Investigator's Abstract) The proposed study will test hypotheses related to gender differences in cardiovascular mortality trends between 1980 and 1991 in two southeastern New England communities. The Specific Aims are organized under four major topic areas: 1) gender differences in trends from 1980 to 1991 in total event rates, hospital discharge rates, in-hospital case-fatality and out of hospital deaths for coronary heart disease (CHD) and stroke; 2) gender specific analyses of methodological issues which may affect the interpretation of morbidity and mortality surveillance data; 3) gender differences in the presentation, diagnosis, and treatment of CHD and stroke which may influence morbidity and mortality trends; and 4) gender differences in the association between population trends in risk factors and morbidity and mortality trends. These aims will be accomplished using morbidity and mortality data collected by the Pawtucket Heart Health Program between 1980 and 1993, and risk factor data obtained through biennial cross-sectional household health surveys conducted in random samples of residents in the two study communities. Morbidity and mortality data were obtained according to standardized epidemiologic surveillance methods. Hospitalized cases of coronary heart disease and stroke were identified through hospital discharge records and were validated using a standardized diagnostic algorithm based on data abstracted from medical records. Out-of-hospital deaths identified through death certificate data were validated using an algorithm based upon medical history data and information concerning the circumstances of death obtained from informant interviews. Gender specific trends in both age-adjusted and age specific morbidity and mortality will be compared. Trends in rates estimated from events classified according to ICD-9 discharge and death certificate codes will be contrasted with those estimated from cases validated by standardized diagnostic algorithms. Data regarding circumstances of death and in-hospital treatment will be assessed in relation to potential influences on morbidity and mortality trends. Absolute changes over time and average annual percent change over time will be evaluated using linear and log-linear regression techniques. Other analytic methods will include logistic regression and analysis of variance. Expected annual event rates in men and women will be estimated from risk factor data using equations based upon accelerated failure time Weibull models, and the impact of risk factor on mortality rates will be assessed by comparing predicted with actual rates.

描述：（改编自研究者摘要）拟定的研究将 心血管疾病死亡率性别差异相关假设检验 1980年至1991年间，新英格兰东南部的两个社区的发展趋势。 具体目标分为四个主要专题领域：1）性别 1980年至1991年总事件发生率的趋势差异，医院 出院率、院内病死率和院外死亡率 冠心病（CHD）和中风; 2）性别特异性分析 可能影响发病率解释的方法学问题， 死亡率监测数据; 3）性别差异的介绍， 冠心病和中风的诊断和治疗，这可能会影响发病率， 死亡率趋势;以及4） 危险因素的人口趋势以及发病率和死亡率趋势。 这些目标将利用收集到的发病率和死亡率数据来实现 1980年至1993年期间，Pawtucket心脏健康计划， 通过两年一次的住户健康横断面调查获得的数据 在两个研究社区的居民随机抽样进行。 发病率和死亡率数据根据标准化的 流行病学监测方法。 冠心病住院病例 通过出院记录识别疾病和中风， 使用基于数据的标准化诊断算法进行验证 从医疗记录中提取出来的 通过以下方式确定的院外死亡 死亡证明数据使用基于医学的算法进行验证， 获得的关于死亡情况的历史数据和信息 从线人的访谈中 按年龄调整的发病率和按年龄划分的发病率的性别趋势， 将比较死亡率。 根据事件估计的发生率趋势 根据ICD-9出院和死亡证明代码分类， 与通过标准化验证的病例估计值相比， 诊断算法 关于死亡情况的数据， 将评估住院治疗的潜在影响 发病率和死亡率趋势。 一段时间内的绝对变化和平均值 将使用线性和 对数线性回归技术。 其他分析方法包括 Logistic回归和方差分析。 预期年度事件发生率 男性和女性的风险因素数据将使用公式进行估计 基于加速失效时间威布尔模型， 死亡率的因素将通过比较预测的 实际利率。