Study of Women's Health Across the Nation (SWAN): New Jersey

全国妇女健康研究 (SWAN)：新泽西州

• 批准号: 9132656
• 负责人: CAROL A. DERBY
• 金额: $ 40.04万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9132656
• 关键词: Address; Adopted; Adrenal Glands; Adrenal hormone preparation; Age; Aging; Androstenediols; Biological; Biological Assay; Biology; Body Composition; Body Size; Body mass index; Bone Density; CLIA certified; Calendar; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Characteristics; Charge; Chinese People; Chronology; Clinical; Cohort Studies; Data; Data Collection; Dehydroepiandrosterone Sulfate; Disease; Disease Outcome; Enrollment; Estradiol; Ethnic Origin; Ethnic group; Event; Follicle Stimulating Hormone; Fracture; Genitourinary system; Gonadal Steroid Hormones; Health; Hemostatic function; Hispanics; Hormonal Change; Hormones; Inflammation; Inflammatory; Japanese Population; Knowledge; Laboratories; Life Experience; Link; Measures; Mediator of activation protein; Menopause; Menstruation; Methods; Mission; Natural History; Nature; New Jersey; Outcome; Ovarian; Pattern; Perimenopause; Personal Satisfaction; Physical Function; Physiological; Physiology; Positioning Attribute; Postmenopause; Premenopause; Prevention program; Protocols documentation; Race; Recording of previous events; Reproductive Health; Research Infrastructure; Resources; Risk; Risk Factors; Sex Functioning; Sex Hormone-Binding Globulin; Shapes; Signal Transduction; Site; Sleep; Socioeconomic Status; Specimen; Steroids; Symptoms; Testosterone; Time; Vagina; Variant; Vasomotor; Visit; Woman; Women' s Health; Work; actigraphy; adipokines; age related; bone; clinical practice; clinically relevant; cognitive function; cohort; dehydroepiandrosterone; design; disorder risk; experience; follow-up; functional outcomes; hormone binding protein; innovation; insight; middle age; mood symptom; psychologic; psychosocial; public health relevance; racial and ethnic; racial difference; repository; reproductive senescence; response; skeletal; social; socioeconomics; treatment program

DESCRIPTION (provided by applicant): This is the amended competing renewal application of the Study of Women's Health Across the Nation (SWAN), a 7-site longitudinal cohort study initiated in 1994 in response to RFA AG-94-002. SWAN was mandated "to characterize the chronology of the biological and psychosocial antecedents and sequelae of the menopausal transition (MT) and the effect of this transition on subsequent health and risk factors for age- related disease", and to extend this information from White women to "...the range of peri-menopausal experiences in women of other racial/ethnic background(s)." A total of 3302 Black, Chinese, Japanese, Hispanic and White women were enrolled, with 78% completing up to 13 visits spanning the premenopause to early post-menopause (PM). Thus far, SWAN has described the natural history of the MT -- its timing, patterns of hormonal changes, and symptoms and factors related to them - and their relation to disease risk indicators. During SWAN V, we will extend observations through the late PM, a necessary step to assess the impact of the MT on age-related diseases. Our specific aims are to: 1) complete the characterization of the natural history of reproductive aging through the late PM; 2) evaluate the impact of reproductive aging through the late PM on health outcomes clinically relevant to women in their 60s and 70s, including: cognitive and physical function, psychological well-being, sleep, bone and cardiometabolic health, urogenital symptoms, sexual function and vaginal health; and 3) identify potential underlying mechanisms linking reproductive aging and health by assessing the relation of inflammation, hemostasis and adipokines to the occurrence and progression of biological, functional and clinical outcomes and delineating the interrelationships of body size and composition, race/ethnicity and socioeconomic status with these outcomes. The SWAN V Core protocol will be completed at 7 study sites, with bone and cardiovascular studies at 4 sites and actigraphy studies in a subset of women at all sites. Longitudinal specimens from the SWAN Repository will enable characterization of skeletal markers, adrenal hormones, hemostasis, inflammation, and adipokines across the MT into PM. The Coordinating Center will provide the necessary organizational infrastructure, statistical resources, and timely dissemination of high quality SWAN data. The CLIA-certified Central Laboratory will perform or coordinate with other laboratories to provide accurate, high volume assays, adopting new methods as needed to provide state- of-the-art data. SWAN is uniquely positioned to fill important scientific gaps in understanding of the impact of the MT on women's health in their 60s and 70s and to facilitate the application of new knowledge to clinical practice. With 1.5 decades of both calendar time and "menopause time", SWAN V can disaggregate the contributions of aging and the MT to women's health, address difficult and critical questions about the temporal nature of MT-disease associations, assess differences by race/ethnicity, and provide insights into modifiable factors relevant to the design of innovative prevention and treatment programs for aging women.

描述（由申请人提供）：这是全国女性健康研究（SWAN）的修订竞争性更新申请，该研究是一项7家中心的纵向队列研究，于1994年启动，以响应RFA AG-94-002。SWAN的任务是“描述绝经过渡期（MT）的生物学和心理社会前因和后遗症的年表以及这种过渡对随后的健康和年龄相关疾病的风险因素的影响”，并将这一信息从白色妇女扩展到“.其他种族/民族背景女性的围绝经期经历范围。共有3302名黑人、中国人、日本人、西班牙裔和白色妇女参加了研究，其中78%完成了从绝经前到绝经后早期（PM）的13次访视。到目前为止，SWAN已经描述了MT的自然史-其时间、激素变化模式、症状和相关因素-及其与疾病风险指标的关系。在SWAN V期间，我们将延长观察到晚PM，这是评估MT对年龄相关疾病影响的必要步骤。我们的具体目标是：2）评估晚期PM生殖老化对60岁和70岁女性临床相关健康结果的影响，包括：认知和身体功能，心理健康，睡眠，骨骼和心脏代谢健康，泌尿生殖系统症状，性功能和阴道健康;和3）通过评估炎症、止血和脂肪因子与生物学、功能和临床结果的发生和进展的关系，并描述身体大小和组成、种族/民族和社会经济地位与这些结果的相互关系，确定将生殖老化和健康联系起来的潜在潜在机制。将在7家研究中心完成SWAN V核心方案，在4家研究中心进行骨骼和心血管研究，并在所有研究中心的女性亚组中进行体动记录研究。来自SWAN储存库的纵向标本将能够表征MT至PM的骨骼标志物、肾上腺激素、止血、炎症和脂肪因子。协调中心将提供必要的组织基础设施、统计资源和及时传播高质量的SWAN数据。CLIA认证的中心实验室将执行或与其他实验室协调，以提供准确的高容量检测，并根据需要采用新方法提供最先进的数据。SWAN具有独特的优势，可以填补重要的科学空白，了解MT对60多岁和70多岁女性健康的影响，并促进新知识在临床实践中的应用。凭借1.5年的日历时间和“更年期时间”，SWAN V可以分解衰老和MT对女性健康的贡献，解决有关MT与疾病关联的时间性质的困难和关键问题，评估种族/民族的差异，并提供与设计创新预防和治疗计划相关的可修改因素的见解。