Tissue and Pathology Resources

组织和病理学资源

• 批准号: 8395574
• 负责人: BOGDAN A CZERNIAK
• 金额: $ 28.79万
• 依托单位: SARC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-26 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8395574
• 关键词: Biological Markers; Biology; Caring; Childhood; Clinical; Clinical Trials; Collaborations; Complex; Data; Databases; Diagnostic; Disease; Ensure; Evaluation; Ewings sarcoma; Family; Future; Gene Expression; Genetic; Goals; Grant; Guidelines; Histologic; Human; Individual; Institution; Investigation; Karyotype; Malignant Neoplasms; Malignant Peripheral Nerve Sheath Tumor; Nature; Neurofibromatosis 1; Normal tissue morphology; Orphan; Pathologic; Pathologist; Pathology; Patients; Pediatric Hospitals; Procedures; Process; Protocols documentation; Quality Control; Records; Research; Research Personnel; Research Project Grants; Resources; Sampling; Services; Specimen; Syndrome; Techniques; Tissue Microarray; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Tumor Tissue; Undifferentiated; base; design and construction; experience; high throughput analysis; human tissue; improved; leiomyosarcoma; prospective; repository; response; sarcoma; tissue resource; treatment effect; tumor

The projects of this SPORE will use human sarcoma specimens for translational research directed toward improving the treatment of human sarcomas. The Sarcoma Pathology and Tissue Procurement Core will provide SPORE investigators with high-quality tissue samples from pafients treated at SPORE and Sarcoma Alliance for Research and Collaboration (SARC) associated institutions. Standardized and centralized procedures have been established for fissue procurement, quality control, and processing, storage, and distribufion of samples to individual investigators and will ensure opfimal use of the samples according to the guidelines established by the Specimen Committee. Funcfions of SarCore will include specimen procurement from participating SARC insfitufions, processing, storage, histopathologic review, tesfing, and management of pathological databases as well as distribution of well-characterized specimens to project invesfigators. The Biopathology Center (BCP) at Nationwide Children's Hospital (Columbus, OH) will faciliate processing of prospective clinical samples with Dr. Nilsa Ramirez as a local consultant there supported by this grant. The electronic database is integrated with the Biostafisfics and Clinical Trials Cores and contains both pathological and clinical records of all samples, both stored and distributed to individual invesfigators, and includes the results of individual SPORE projects to facilitate the efficient response of SarCore to the needs of invesfigators in this SPORE and at collaborating institufions. These resources will also be available for future use under the NCI CaBIG¿ protocol. Two pathologists (Drs. Czerniak and Lazar) with expertise in sarcoma pathology, biology and in all aspects of Core operafions, including histopathologic evaluation, experimentafion and quality control, will co-direct the facility. They will be supported by Drs. Matt van de Rijn (Stanford) and Christopher Fletcher (Harvard), all with extensive experience in sarcoma pathology and translafional research. Dr. van de Rijn is expert in high-throughput analysis sarcoma biomarkers and sarcoma pathobiology while Dr. Fletcher's clinical diagnostic opinions are widely regarded as definitive In this complex arena. This centralized comprehensive facility will provide experimental support and close collaborafion forthe mulfidisciplinary and translational research projects oufiined in this SPORE proposal. All five pathologists in this core has extensive experience in this regard. Such support is necessary in this rare family of understudied orphan malignancies where only mulfi-institufional cooperafion can facilitate the acquisifion of human tumor tissue resources vital to make progress in this understudied disease.

这个孢子的项目将使用人类肉瘤标本进行翻译研究，目的是 改进对人类肉瘤的治疗。肉瘤病理学和组织采购核心将 为孢子研究人员提供来自孢子和肉瘤患者的高质量组织样本 研究与合作联盟(SARC)关联机构。标准化和集中化 已经建立了采购、质量控制和加工、储存和销售的程序 将样本分发给个别调查人员，并将确保样本的合理使用 标本委员会制定的指导方针。SarCore的功能将包括标本 从参与的SARC设备采购、加工、储存、组织病理学检查、测试和 管理病理数据库以及将具有良好特征的标本分发到项目 投资人。全国儿童医院(哥伦布，俄亥俄州)的生物病理中心(BCP)将提供便利 由尼尔萨·拉米雷斯博士作为当地顾问处理预期的临床样本，由 这笔赠款。电子数据库与Biostafisfics和临床试验核心集成在一起，包含 所有样本的病理和临床记录，包括存储和分发给个别调查人员， 并包括各个孢子项目的结果，以促进SarCore对 在这个孢子和合作机构中投资人的需求。这些资源也将可用 以备将来在NCI CaBIG？协议下使用。两位病理学家(Czerniak博士和Lazar博士)在 肉瘤病理学、生物学和核心手术的所有方面，包括组织病理学评估， 实验和质量控制，将共同指导该设施。他们将得到马特·范德里恩博士的支持 (斯坦福大学)和克里斯托弗·弗莱彻(哈佛大学)，都在肉瘤病理学和 跨国界的研究。Van de Rijn博士是高通量分析肉瘤生物标志物和 肉瘤病理生物学，而弗莱彻博士的临床诊断意见被广泛认为是这方面的权威 复杂的竞技场。这个集中的综合设施将提供试验性支持并关闭 本提案中提出的多学科和翻译研究项目的合作。 这一核心的五位病理学家在这方面都有丰富的经验。在这方面，这种支持是必要的 罕见的研究不足的孤儿恶性肿瘤家族，只有多机构合作才能促进 获取人类肿瘤组织资源对于在这一未被研究的疾病中取得进展至关重要。