Pathology and Data Management

该核心的任务是提供所需的具有良好特性的、高质量的人类衍生生物标本 这些项目并确保与治疗和结果相关的纵向、结构化的临床信息 是从这些标本的患者捐赠者那里收集的。这些基因主要底物 特征化项目是一个独特的资源，由整个器官图组成，将提供组织学 表征和足够的DNA和RNA，以允许在相同的样品上进行多个实验。 这提供了一个前所未有的机会来交叉验证来自这些不同的 实验平台，并应提供，到目前为止，最完整的尿路上皮癌发生和 从未实现过的进步。这一核心将成为解决交叉调查者难题的模式 和跨机构数据交换，在更广泛的背景下具有重大意义的问题 德克萨斯州癌症研究中心。这个核心将提供一个基于Web的门户，允许所有调查人员浏览 并查询生物资源库、未识别的临床数据和翻译研究资源的内容 例如标准操作程序、试剂详细信息和主要数据集。该计划的具体目标 核心内容如下：具体目标1：提供所有组织的病理复习。具体目标2：保持 尿路上皮生物脊髓库，具体目标3：提供专业和技术服务 生物样品库中分子分析物的制备及质量控制。具体目标4： 摘要提供所有提供生物制剂的患者的临床信息。具体目标5：纵向捕获 对所有提供生物有机磷农药的患者进行临床随访。具体目标6：确保所有与黑手党有关的信息 到孢子项目是可以交换的。具体目标7：为所有孢子发酵剂提供共同的 用于访问项目数据的门户，包括支持跨项目和域的即席查询。

The task of this Core is to provide well characterized, high-quality human-derived biospecimens required by the projects and to insure that longitudinal, structured, clinical information related to treatment and outcome is collected from the patient donors of those specimens. The primary substrate for these genetic characterization projects is a unique resource consisting of whole-organ maps that will provide histologic characterization and sufficient DNA and RNA to allow multiple experiments to be done on the same samples. This provides an unprecedented opportunity to cross-validate biologic insights coming from these different experimental platforms, and should provide, by far, the most complete view of urothelial carcinogenesis and progression ever realized. This Core will serve as a model for addressing the difficult problems of crossinvestigator and cross-institutional data exchange, issues of significant interest for the broader context of Texas cancer research. This Core will provide a web-based portal that will allow all investigators to browse and query the contents of the biorepository, de-identified clinical data, and translational research resources such as Standard Operating Procedures, reagent details, and primary datasets. The specific aims for the core are as follows: Specific Aim 1: Provide pathologic review of all tissues. Specific Aim 2: Maintain a urothelial biospecimen repository, Specific Aim 3: Provide professional and technical services for the preparation and quality control of molecular analytes from the biospecimen repository. Specific Aim 4: Abstract clinical informafion for all pafients providing biospecimens. Specific Aim 5: Capture longitudinal clinical follow-up on all patients providing biospecimens. Specific Aim 6: Assure that all informafion related to the SPORE Project is exchangeable. Specific Aim 7: Provide all SPORE Invesfigators with a common portal for access to Project data, including support for ad hoc query across projects and domains.