Pathology and Data Management

病理学和数据管理

• 批准号: 8230260
• 负责人: BOGDAN A CZERNIAK
• 金额: $ 20.32万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8230260
• 关键词: Address; Cancer cell line; Clinical; Clinical Data; DNA; Data; Data Set; Detection; Ensure; Genetic; Guidelines; Histologic; Human; Individual; Institutional Review Boards; Instruction; Malignant neoplasm of urinary bladder; Maps; Modeling; Molecular; Online Systems; Organ; Pathologic; Pathology; Patients; Preparation; Prevention; Procedures; Process; Quality Control; RNA; Reagent; Research; Research Personnel; Resources; Sampling; Services; Specimen; Structure; Texas; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Treatment outcome; University of Texas M D Anderson Cancer Center; Urogenital Cancer; abstracting; anticancer research; biobank; cancer diagnosis; carcinogenesis; data exchange; data management; follow-up; improved; insight; interest; repository; research study

The task of this Core is to provide well characterized, high-quality human-derived biospecimens required by the projects and to insure that longitudinal, structured, clinical information related to treatment and outcome is collected from the patient donors of those specimens. The primary substrate for these genetic characterization projects is a unique resource consisting of whole-organ maps that will provide histologic characterization and sufficient DNA and RNA to allow multiple experiments to be done on the same samples. This provides an unprecedented opportunity to cross-validate biologic insights coming from these different experimental platforms, and should provide, by far, the most complete view of urothelial carcinogenesis and progression ever realized. This Core will serve as a model for addressing the difficult problems of crossinvestigator and cross-institutional data exchange, issues of significant interest for the broader context of Texas cancer research. This Core will provide a web-based portal that will allow all investigators to browse and query the contents of the biorepository, de-identified clinical data, and translational research resources such as Standard Operating Procedures, reagent details, and primary datasets. The specific aims for the core are as follows: Specific Aim 1: Provide pathologic review of all tissues. Specific Aim 2: Maintain a urothelial biospecimen repository, Specific Aim 3: Provide professional and technical services for the preparation and quality control of molecular analytes from the biospecimen repository. Specific Aim 4: Abstract clinical informafion for all pafients providing biospecimens. Specific Aim 5: Capture longitudinal clinical follow-up on all patients providing biospecimens. Specific Aim 6: Assure that all informafion related to the SPORE Project is exchangeable. Specific Aim 7: Provide all SPORE Invesfigators with a common portal for access to Project data, including support for ad hoc query across projects and domains.

该核心的任务是提供特征明确、高质量的人源生物样本，以满足 项目并确保与治疗和结果相关的纵向、结构化、临床信息 从这些样本的患者捐赠者那里收集。这些遗传的主要底物 表征项目是一种独特的资源，由全器官图组成，可提供组织学信息 表征以及足够的 DNA 和 RNA，以便在同一样本上进行多次实验。 这提供了前所未有的机会来交叉验证来自这些不同的生物学见解 实验平台，并且应该提供迄今为止最完整的尿路上皮癌发生和 曾经实现的进步。该核心将作为解决交叉研究者难题的模型 和跨机构数据交换，更广泛的背景下具有重大意义的问题 德克萨斯州癌症研究。该核心将提供一个基于网络的门户，允许所有调查人员浏览 查询生物样本库内容、去标识化临床数据、转化研究资源 例如标准操作程序、试剂详细信息和主要数据集。具体目标为 core are as follows: Specific Aim 1: Provide pathologic review of all tissues.具体目标 2：维持 尿路上皮生物样本库，具体目标3：为尿路上皮生物样本库提供专业技术服务 生物样本库中分子分析物的制备和质量控制。具体目标 4： 为所有提供生物样本的患者提供摘要临床信息。具体目标 5：捕获纵向 对所有提供生物样本的患者进行临床随访。具体目标 6：确保所有相关信息 SPORE 项目是可交换的。具体目标 7：为所有 SPORE 调查员提供共同的 用于访问项目数据的门户，包括支持跨项目和域的即席查询。