Pathology and Data Management

该核心的任务是提供所需的表征良好的高质量人源性生物标本， 项目，并确保与治疗和结果相关的纵向，结构化，临床信息 是从那些标本的患者捐献者那里收集的。这些基因的主要底物 表征项目是一个独特的资源，包括整个器官的地图，将提供组织学 这些样品具有足够的DNA和RNA，以允许在相同样品上进行多次实验。 这提供了一个前所未有的机会，可以交叉验证来自这些不同生物的生物学见解。 实验平台，并应提供，到目前为止，最完整的看法尿路上皮癌， 实现的进步。该核心将作为解决交叉调查者难题的模型 和跨机构数据交换，这些问题对更广泛的 德州癌症研究中心。该核心将提供一个基于网络的门户网站，允许所有研究者浏览 并查询生物储存库的内容、去识别临床数据和转化研究资源 例如标准操作规程、试剂详细信息和主要数据集。的具体目标， 核心如下：具体目标1：提供所有组织的病理学检查。目标二：保持 尿路上皮生物标本库，具体目标3：为 从生物样本库制备和质量控制分子分析物。具体目标4： 所有提供生物标本的患者的摘要临床信息。具体目标5：纵向捕获 对提供生物样本的所有患者进行临床随访。具体目标6：确保所有相关信息 是可以交换的具体目标7：为所有SPORE投资者提供一个共同的 用于访问Project数据的门户，包括支持跨项目和域的即席查询。

The task of this Core is to provide well characterized, high-quality human-derived biospecimens required by the projects and to insure that longitudinal, structured, clinical information related to treatment and outcome is collected from the patient donors of those specimens. The primary substrate for these genetic characterization projects is a unique resource consisting of whole-organ maps that will provide histologic characterization and sufficient DNA and RNA to allow multiple experiments to be done on the same samples. This provides an unprecedented opportunity to cross-validate biologic insights coming from these different experimental platforms, and should provide, by far, the most complete view of urothelial carcinogenesis and progression ever realized. This Core will serve as a model for addressing the difficult problems of crossinvestigator and cross-institutional data exchange, issues of significant interest for the broader context of Texas cancer research. This Core will provide a web-based portal that will allow all investigators to browse and query the contents of the biorepository, de-identified clinical data, and translational research resources such as Standard Operating Procedures, reagent details, and primary datasets. The specific aims for the core are as follows: Specific Aim 1: Provide pathologic review of all tissues. Specific Aim 2: Maintain a urothelial biospecimen repository, Specific Aim 3: Provide professional and technical services for the preparation and quality control of molecular analytes from the biospecimen repository. Specific Aim 4: Abstract clinical informafion for all pafients providing biospecimens. Specific Aim 5: Capture longitudinal clinical follow-up on all patients providing biospecimens. Specific Aim 6: Assure that all informafion related to the SPORE Project is exchangeable. Specific Aim 7: Provide all SPORE Invesfigators with a common portal for access to Project data, including support for ad hoc query across projects and domains.