Multidisciplinary Subspecialty Pathology Research Fellowship Program

多学科亚专科病理学研究奖学金计划

• 批准号: 8908891
• 负责人: BOGDAN A CZERNIAK
• 金额: $ 37.98万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-23 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8908891
• 关键词: Fellowship Program; Pathology; Research; multidisciplinary

DESCRIPTION (provided by applicant): Dramatic expansion of biomedical data in the post-genomic era on various organisms, including humans, has disclosed the enormous complexity of biological systems and increased our knowledge of many disease processes. This is particularly evident in reference to neoplastic disorders where molecular technologies on a genome, epigenome, transcriptome and proteomic scale have disclosed unique molecular pathways and their networks that provide significant information concerning therapeutic strategies and clinical outcomes. This in turn has affected the standard of practice of many medical disciplines including pathology. The newly developed concept of personalized and targeted therapies in cancer medicine increased and changed the traditional roles of pathology as a clinical discipline. The expanding molecular testing of tumors, with complex technologic approaches, requires a redesign of the conventional microscopic pathology services. This T32 proposal is intended to provide resources to train a new generation of pathologists via laboratory-based research training that will complement the current Accreditation Council for Graduate Medical Education-accredited clinical fellowship programs of the Department of Pathology at The University of Texas MD Anderson Cancer Center. The goal of this program is to train the next generation of physician/scientist pathologists capable of combining the conventional role of diagnostic pathology with investigative molecular approaches. To accomplish this goal, a focused 2-year research program will pair trainees with experienced educators who are also accomplished translational researchers. The trainees will work in their mentors' laboratories training in laboratory methods, processes, and team orientation needed in today's translational research. The graduates of this program will complete research projects aimed at improving patient care with patient-directed personalized treatment, concluding with the submission of a manuscript to a peer-reviewed journal. Coursework and a wide range of educational opportunities at The University of Texas MD Anderson Cancer Center will complement the laboratory research training. Combined with subspecialty clinical training, this program will produce extremely well-qualified academic, research-oriented pathologists who can, by themselves, be independent researchers and future academic mentors.

描述（由申请人提供）：在后基因组时代，包括人类在内的各种生物体的生物医学数据急剧扩展，揭示了生物系统的巨大复杂性，并增加了我们对许多疾病过程的了解。这在肿瘤性疾病中尤其明显，其中基因组、表观基因组、转录组和蛋白质组规模的分子技术揭示了独特的分子途径及其网络，提供了有关治疗策略和临床结果的重要信息。这反过来又影响了包括病理学在内的许多医学学科的实践标准。癌症医学中新发展的个性化和靶向治疗概念增加并改变了病理学作为临床学科的传统作用。随着复杂技术方法的不断扩展，肿瘤分子检测需要重新设计传统的显微病理学服务。该 T32 提案旨在提供资源，通过基于实验室的研究培训来培训新一代病理学家，这将补充目前德克萨斯大学 MD 安德森癌症中心病理学系研究生医学教育认证委员会认证的临床研究金项目。该计划的目标是培训下一代医师/科学家病理学家，使其能够将诊断病理学的传统作用与研究分子方法相结合。为了实现这一目标，为期两年的重点研究计划将把学员与经验丰富的教育工作者（同时也是出色的转化研究人员）配对。学员将在导师的实验室中接受当今转化研究所需的实验室方法、流程和团队定位培训。该项目的毕业生将完成旨在通过以患者为导向的个性化治疗来改善患者护理的研究项目，最后向同行评审期刊提交手稿。德克萨斯大学 MD 安德森癌症中心的课程作业和广泛的教育机会将补充实验室研究培训。与专科临床培训相结合，该项目将培养出极其合格的学术、研究型病理学家，他们本身可以成为独立的研究人员和未来的学术导师。

项目成果

Supratentorial extraventricular anaplastic ependymoma with extracranial metastasis.

• DOI: 10.1016/j.jocn.2014.09.006
• 发表时间: 2015-03
• 期刊: JOURNAL OF CLINICAL NEUROSCIENCE
• 影响因子: 2
• 作者: Pachella, Laura A.;Kamiya-Matsuoka, Carlos;Lee, Eva Lu T.;Olar, Adriana;Yung, W. K. Alfred
• 通讯作者: Yung, W. K. Alfred

IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO.

IDH突变体弥漫性和变性星形胶质细胞瘤在表现时的年龄相似，而生存的差异很小：谁是谁的评分问题。

• DOI: 10.1007/s00401-015-1438-8
• 发表时间: 2015-06
• 期刊: Acta neuropathologica
• 影响因子: 12.7
• 作者: Reuss DE;Mamatjan Y;Schrimpf D;Capper D;Hovestadt V;Kratz A;Sahm F;Koelsche C;Korshunov A;Olar A;Hartmann C;Reijneveld JC;Wesseling P;Unterberg A;Platten M;Wick W;Herold-Mende C;Aldape K;von Deimling A
• 通讯作者: von Deimling A

Squamous cell carcinoma of parotid gland associated with concurrent lymphoepithelial cysts and lymphoepithelial lesion: case report and proposed histogenesis.

腮腺鳞状细胞癌伴有淋巴上皮囊肿和淋巴上皮病变：病例报告和拟议的组织发生。

• DOI: 10.1007/s12105-014-0571-3
• 发表时间: 2015
• 期刊: Head and neck pathology
• 影响因子: 2.1
• 作者: Zhou,JaneH;ChristopherHolsinger,F
• 通讯作者: ChristopherHolsinger,F

Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: ultrastructural features and differential diagnosis.

• DOI: 10.3109/01913123.2014.950778
• 发表时间: 2015-02
• 期刊: Ultrastructural pathology
• 影响因子: 1
• 作者: Cykowski MD;Hicks J;Sandberg DI;Olar A;Bridge JA;Greipp PT;Navarro P;Kolodziej S;Bhattacharjee MB
• 通讯作者: Bhattacharjee MB

Renal cell carcinoma metastatic to the ovary or fallopian tube: a clinicopathological study of 9 cases.

• DOI: 10.1016/j.humpath.2015.12.017
• 发表时间: 2016-05
• 期刊: Human pathology
• 影响因子: 3.3
• 作者: Liang L;Huang H;Dadhania V;Zhang J;Zhang M;Liu J
• 通讯作者: Liu J