Improving Diagnosis of Bladder Cancer
Improving Diagnosis of Bladder Cancer
批准号:
8230252
负责人:
BOGDAN A CZERNIAK
金额:
$20.32万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
已结题
起止时间:
2011-09-01 至 2017-08-31
关键词:
AddressAffectBedside TestingsBiological MarkersBiopsyBladderBladder NeoplasmCancer DetectionCarcinoma in SituCell CycleCellsCessation of lifeChromosome MappingChronologyClinicalComplementCoupledCystectomyCystoscopyCytologyDNADataDetectionDevelopmentDiagnosisDiagnostic testsDiseaseDistant MetastasisEarly DiagnosisEarly treatmentEventFrequenciesGene Expression ProfilingGene TargetingGenesGenomicsGenotypeGoalsGrantGrowthHematuriaHistologicHumanIn VitroInstructionLicensingMalignant NeoplasmsMalignant neoplasm of urinary bladderMapsModelingMonitorNeoplasm MetastasisOrganPapillaryPathway interactionsPatientsPerformancePhaseProtocols documentationResolutionRoleSamplingSensitivity and SpecificitySurvival RateTechniquesTestingUnited StatesUrineUrogenital CancerValidationangiogenesisaurora-A kinasebasecancer cellcancer invasivenessclinically significantdesigngenome-widehigh riskhuman STK6 proteinimprovedin vivomenminimally invasivenovelnovel diagnosticsoverexpressiontumor progression
中文摘要
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英文摘要
The long-term objective of this project is to improve the detection of one of the common human cancers
arising in the bladder by non-invasive voided urine-based tests. Bladder cancer is the 4"^ most frequent in
men and 5"" most common overall with approximately 70,500 new cases and 14,600 deaths from the disease
in 2009 in the United States. It is estimated that nearly 300,000 patients are regularly monitored in the
United States through a vanety of non-invasive (urine) and minimally invasive (bladder barbotage,
cystoscopy, and biopsy) techniques. Therefore, the development of novel biomarkers that can detect
bladder tumors by a non-invasive approach is of major clinical significance. In this grant, we propose to
complement the existing Multi-Institutional Aurora kinase A FISH Test Biomarker Validation Trial by novel
FISH markers and explore the role of Aurora kinase A in bladder cancer progression. We will compare the
specificity and sensitivity of aurora A FISH test complemented by a panel of novel FISH markers with other
known noninvasive bladder cancer detection tests for voided urine sediments such as urine cytology and
commercially available multi-chromosomal FISH kit known as UroVysion, and NMP22 point-of-care test. A
panel of novel FISH markers will be developed by whole-organ histologic and genetic mapping (WOHGM)
strategy combined with high resolution (IM) lllumina SNP-based genotyping, which provides unique
information on the chronology of genomic alterations that parallel the development of bladder cancer from
early field effects to invasive disease. Our strong preliminary data indicate that this approach offers a unique
opportunity to design novel biomarkers that may address the specific phases of bladder cancer development
along these superficial papillary and high grade nonpapillary Invasive pathways. Moreover, we propose to
investigate the role of aurora kinase A and its regular pathway in bladder cancer progression to invasive
disease and distant metastasis. The specific aims of this project are as follows: Specific Aim 1: Develop a
panel of novel FISH markers for bladder cancer. Specific Aim 2: Validate a novel set of FISH biomarkers
for bladder cancer. Specific Aim 3: Investigate the role of Aurora kinase A in bladder cancer growth,
angiogenesis, invasion and metastasis.
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Tissue and Pathology Resources
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批准号:8395574
-
项目类别:
-
资助金额:$28.79万
-
财政年份:2012
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
Multidisciplinary Subspecialty Pathology Research Fellowship Program
-
批准号:8337748
-
项目类别:
-
资助金额:$43.89万
-
财政年份:2011
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
Multidisciplinary Subspecialty Pathology Research Fellowship Program
-
批准号:8214237
-
项目类别:
-
资助金额:$21.38万
-
财政年份:2011
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
Multidisciplinary Subspecialty Pathology Research Fellowship Program
-
批准号:8540854
-
项目类别:
-
资助金额:$37.33万
-
财政年份:2011
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
Pathology and Data Management
-
批准号:8230260
-
项目类别:
-
资助金额:$20.32万
-
财政年份:2011
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
Multidisciplinary Subspecialty Pathology Research Fellowship Program
-
批准号:8721730
-
项目类别:
-
资助金额:$28.25万
-
财政年份:2011
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
Multidisciplinary Subspecialty Pathology Research Fellowship Program
-
批准号:8908891
-
项目类别:
-
资助金额:$37.98万
-
财政年份:2011
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
Aurora Kinase A as a Biomarker for the Detection of Bladder Cancer
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批准号:8287655
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项目类别:
-
资助金额:$39.08万
-
财政年份:2010
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
Aurora Kinase A as a Biomarker for the Detection of Bladder Cancer
-
批准号:8468663
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项目类别:
-
资助金额:$36.35万
-
财政年份:2010
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
Aurora Kinase A as a Biomarker for the Detection of Bladder Cancer
-
批准号:8105195
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项目类别:
-
资助金额:$39.51万
-
财政年份:2010
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
Specimen Core
-
批准号:7729511
-
项目类别:
-
资助金额:$12.49万
-
财政年份:2008
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
Forerunner Genes: A Novel Class of Early Detection Markers for Bladder Cancer
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批准号:7729503
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项目类别:
-
资助金额:$24.51万
-
财政年份:2008
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
EARLY DETECTION OF URINARY BLADDER CANCER
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批准号:6074937
-
项目类别:
-
资助金额:$65.11万
-
财政年份:1999
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
EARLY DETECTION OF URINARY BLADDER CANCER
-
批准号:6522563
-
项目类别:
-
资助金额:$77.4万
-
财政年份:1999
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
EARLY DETECTION OF URINARY BLADDER CANCER
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批准号:7113134
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项目类别:
-
资助金额:$51.5万
-
财政年份:1999
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
EARLY DETECTION OF URINARY BLADDER CANCER
-
批准号:7483250
-
项目类别:
-
资助金额:$52.76万
-
财政年份:1999
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
EARLY DETECTION OF URINARY BLADDER CANCER
-
批准号:6175327
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项目类别:
-
资助金额:$73.49万
-
财政年份:1999
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
EARLY DETECTION OF URINARY BLADDER CANCER
-
批准号:6644812
-
项目类别:
-
资助金额:$77.41万
-
财政年份:1999
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
EARLY DETECTION OF URINARY BLADDER CANCER
-
批准号:6848379
-
项目类别:
-
资助金额:$47.16万
-
财政年份:1999
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
EARLY DETECTION OF URINARY BLADDER CANCER
-
批准号:6377572
-
项目类别:
-
资助金额:$84.67万
-
财政年份:1999
-
负责人:BOGDAN A CZERNIAK
-
依托单位:
海外基金