Molecular Genetics and Epigenetics

导致肿瘤功能丧失的遗传和表观遗传变化的积累 抑制子和/或原癌基因的不适当激活是癌症的标志。的目标 分子遗传学和表观遗传学计划（GEN）是了解分子机制， 这些缺陷的基础，并发现新的治疗，诊断，预后和预防的目标。的 该计划利用了大量的优秀invesfigators在弗吉尼亚大学与研究专业知识， 染色质结构、转录、复制。突变、修复和癌症细胞检查点。的 成员围绕四个主题组织：（1）染色体功能，故障和细胞 检查点;（2）表观遗传学和癌症;（3）癌症中的信号传导和基因表达;以及（4）生物信息学： 从人类基因组中挖掘信息。该项目由Joyce L.哈姆林博士， 哺乳动物DNA复制和肿瘤细胞中的大规模染色体重排; Dutta，MD，PhD是复制和细胞周期领域的领导者.杜塔博士最近更关注 microRNA在肿瘤发生中的作用通过其活动。GEN提供了一个正式的机制， 成员之间的知识交流和合作。该计划目前包括32个完整的 来自11个不同部门的会员和6名准会员。其中21人是新来的 自上次更新以来，该计划或UVA，他们带来了生物信息学方面的大量专业知识 微阵列和深度测序数据，大规模基因组重排（包括非整倍体）。和 辐射的分子效应和细胞对辐射的反应。对于此次更新，GEN已 增加了一个重要的队列，其研究重点是 肿瘤类型，包括肺和脑肿瘤，或辐射损伤。2004 - 2005两年期校外供资共计 该计划超过1480万美元，其中包括来自国家癌症研究所（NCI）的340万美元和一个奖项 来自美国癌症协会。项目成员制作了390份与癌症有关的出版物， 自上次更新以来，32%为方案间，18%为方案内。另外。 计划成员参与多个投资者和合作的国家卫生研究机构 获奖，包括来自NCI的18笔赠款。

The accumulation of heritable genetic and epigenefic changes that result in loss of funcfion of tumor suppressors and/or inappropriate activation of proto-oncogenes is a hallmark of cancer. The goals of the Molecular Genetics and Epigenetics Program (GEN) are to understand the molecular mechanisms that underiie these defects and to uncover new targets for therapy, diagnosis, prognosis, and prevention. The Program capitalizes on the large number of outstanding invesfigators at UVA with research expertise in chromafin architecture, transcription, replicafion. mutation, repair, and cellular checkpoints in cancer. The Members are organized around four main themes: (1) Chromosome funcfion, malfunction, and cellular checkpoints; (2) Epigenefics and cancer; (3) Signaling and gene expression in cancer; and (4) Bioinformatics: mining informafion from human genomes. The Program is led by Joyce L. Hamlin, PhD, an expert in mammalian DNA replicafion and large-scale chromosome rearrangements in tumor cells; and by Anindya Dutta, MD, PhD a leader in the replicafion and cell cycle fields. Dr. Dutta has focused more recenfiy on the role of microRNAs in tumorigenesis. Through its acfivities. GEN provides a formal mechanism for fostering intellectual exchange and collaboration among its Members. The Program currently consists of 32 Full Members and 6 Associate Members from 11 different departments. Twenty one of these individuals are new to the Program or to UVA since the last renewal, and they bring considerable expertise in the bioinformatics of microarray and deep-sequencing data, large-scale genomic rearrangements (including aneuploidy). and the molecular effects of radiafion and cellular responses to radiation. Importanfiy for this renewal, GEN has added a significant cohort of translafional and clinical invesfigators whose research focus is on particular tumor types, including lung and brain tumors, or on radiafion damage. Total extramural funding for the Program exceeds $14.8 million, including $3.4 million from the Nafional Cancer Institute (NCI) and an award from the American Cancer Society. Program Members have produced 390 cancer-relevant publicafions, of which 32% were inter-programmatic and 18% were intra-programmatic since the last renewal. In addition. Program Members participate in multi-invesfigator and collaborative Nafional Insfitutes of Health research awards, including 18 grants from NCI.