Diffuse Optical Monitoring of Head and Neck Tumor Therapy

头颈肿瘤治疗的漫射光学监测

基本信息

  • 批准号:
    8266452
  • 负责人:
  • 金额:
    $ 29.01万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-07-01 至 2015-04-30
  • 项目状态:
    已结题

项目摘要

Project Summary: Treatment with radiation or chemo-radiotherapy is the standard therapy for head and neck cancers but this treatment is well known to be less efficacious in patients with hypoxic tumors. Furthermore, cancer therapy may alter tumor physiological status, thus impacting treatment efficacy. Factors that modulate tumor oxygenation include blood flow, blood oxygenation, oxygen metabolism, and nicotine levels (i.e., tobacco use). Tumor hemodynamics and metabolism, however, are not routinely measured during cancer therapy due to the lack of appropriate technologies. Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) are the best currently available and reproducible methods to measure target lesions selected for objective response assessment, but these modalities require large and costly instrumentation that severely limits their routine use in clinics. The capabilities of diffuse optics for continuously monitoring tumor hemodynamics and metabolism during therapy at the clinical bedside have recently been demonstrated in our preliminary studies. The objective of this project is to develop and optimize a noninvasive versatile multi-modality clinical optical instrument to aid in evaluating and predicting tumor responses at the most early stage possible. More specifically, this optical instrument will monitor and predict hemodynamic and metabolic responses to chemo- radiotherapy in head and neck tumors. We hypothesize that functional assessment of tumor physiological status and dynamic changes during therapy will provide information for early prediction of long-term treatment outcomes, thus enabling clinicians to optimize therapy for each patient in a time sensitive fashion. To achieve this goal, we will assemble a hybrid flow and oxygen system that combines a newly developed diffuse correlation spectroscopy (DCS) flowmeter with a commercial tissue-oximeter for simultaneous measurement of tumor blood flow, oxygenation, and oxygen metabolism (derived from the flow and oxygenation data). The instrument including optical probes and a software platform will be tested and optimized for continuous and longitudinal monitoring of tumor physiological status and hemodynamic/metabolic changes before, during and after therapy in patients including smokers and nonsmokers (n=125). It is anticipated that significant correlations will be observed between therapy outcomes (e.g., tumor volume change, tumor toxicity, time to disease recurrence, survival) and tumor physiological status and changes as well as nicotine levels. Different types of physiological parameters may show different sensitivities to cancer therapy in each patient, which could reveal the primary factor(s) affecting individual therapy outcomes. Our novel hybrid optical system will provide hemodynamic and metabolic imaging contrasts complementary to those of CT and MRI, and holds unique potential for early evaluating and predicting cancer therapy responses. Our long-term goal is to develop robust scientific collaborations to optimize and individualize cancer therapy at early stages with noninvasive optical technologies.
项目总结: 放射治疗或化疗-放射治疗是头颈部癌症的标准治疗方法,但这 众所周知,低氧肿瘤患者的治疗效果较差。此外,癌症治疗 可能改变肿瘤的生理状态,从而影响治疗效果。调节肿瘤的因素 氧合作用包括血流量、血液氧合作用、氧代谢和尼古丁水平(即吸烟)。 然而,在癌症治疗期间,肿瘤的血流动力学和新陈代谢并不是常规的测量,因为 缺乏适当的技术。计算机断层扫描(CT)和磁共振成像(MRI)是 目前可用和可重复性最好的方法来测量被选作客观反应的目标皮损 评估,但这些模式需要大量昂贵的仪器,严重限制了它们的常规使用 在诊所里。漫反射光学连续监测肿瘤血流动力学和代谢的能力 在临床床边进行治疗,最近在我们的初步研究中得到了证实。这个 本项目的目标是开发和优化无创、多功能的多模式临床光学系统 有助于在尽可能早的阶段评估和预测肿瘤反应的仪器。更多 具体地说,这种光学仪器将监测和预测血液动力学和代谢对化疗的反应。 头颈部肿瘤的放射治疗。我们假设对肿瘤的生理功能评估 治疗过程中的状态和动态变化将为早期预测长期治疗提供信息 结果,从而使临床医生能够以时间敏感的方式优化每个患者的治疗。要实现 为了实现这个目标,我们将组装一种混合流动和氧气系统,它结合了新开发的漫反射 相关光谱分析(DCS)流量计与商用组织血氧仪同时测量 肿瘤血流量、氧合和氧代谢(来源于血流和氧合数据)。这个 包括光学探头和软件平台在内的仪器将进行测试和优化,以实现连续和 术前、术中、术中肿瘤生理状态及血流动力学/代谢变化的纵向监测 治疗后患者包括吸烟者和非吸烟者(n=125)。预计这一重大事件 将观察治疗结果之间的相关性(例如,肿瘤体积变化、肿瘤毒性、 疾病复发、存活率)和肿瘤生理状态及变化以及尼古丁水平。不同 每个患者的生理参数类型可能对癌症治疗的敏感性不同, 可以揭示影响个体治疗结果的主要因素(S)。我们的新型混合光学系统将 提供与CT和MRI互补的血流动力学和代谢成像对比,并保持 早期评估和预测癌症治疗反应的独特潜力。我们的长远目标是发展 强有力的科学合作,以优化和个体化的癌症治疗在早期阶段与非侵入性 光学技术。

项目成果

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Guoqiang Yu其他文献

Guoqiang Yu的其他文献

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{{ truncateString('Guoqiang Yu', 18)}}的其他基金

Time-resolved laser speckle contrast imaging of resting-state functional connectivity in neonatal brain
新生儿大脑静息态功能连接的时间分辨激光散斑对比成像
  • 批准号:
    10760193
  • 财政年份:
    2023
  • 资助金额:
    $ 29.01万
  • 项目类别:
Development of a Wearable Fluorescence Imaging Device for IntraoperativeIdentification of Brain Tumors
开发用于术中识别脑肿瘤的可穿戴荧光成像装置
  • 批准号:
    10697009
  • 财政年份:
    2023
  • 资助金额:
    $ 29.01万
  • 项目类别:
Integrating Astrocytes into Models of Neural Circuits Regulating Behavior
将星形胶质细胞整合到调节行为的神经回路模型中
  • 批准号:
    10294803
  • 财政年份:
    2021
  • 资助金额:
    $ 29.01万
  • 项目类别:
Data Science Core
数据科学核心
  • 批准号:
    10294802
  • 财政年份:
    2021
  • 资助金额:
    $ 29.01万
  • 项目类别:
Integrating Astrocytes into Models of Neural Circuits Regulating Behavior
将星形胶质细胞整合到调节行为的神经回路模型中
  • 批准号:
    10461225
  • 财政年份:
    2021
  • 资助金额:
    $ 29.01万
  • 项目类别:
Integrating Astrocytes into Models of Neural Circuits Regulating Behavior
将星形胶质细胞整合到调节行为的神经回路模型中
  • 批准号:
    10693168
  • 财政年份:
    2021
  • 资助金额:
    $ 29.01万
  • 项目类别:
Data Science Core
数据科学核心
  • 批准号:
    10461224
  • 财政年份:
    2021
  • 资助金额:
    $ 29.01万
  • 项目类别:
Data Science Core
数据科学核心
  • 批准号:
    10693164
  • 财政年份:
    2021
  • 资助金额:
    $ 29.01万
  • 项目类别:
High-density optical tomography of cerebral blood flow and metabolism in small animals
小动物脑血流和代谢的高密度光学断层扫描
  • 批准号:
    10323090
  • 财政年份:
    2021
  • 资助金额:
    $ 29.01万
  • 项目类别:
High-density optical tomography of cerebral blood flow and metabolism in small animals
小动物脑血流和代谢的高密度光学断层扫描
  • 批准号:
    10461939
  • 财政年份:
    2021
  • 资助金额:
    $ 29.01万
  • 项目类别:

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