Dermatoscopy in the Evaluation of Pigmented Lesions

皮肤镜检查在色素病变评估中的应用

• 批准号: 8349125
• 负责人: thomas j hornyak
• 金额: $ 6.55万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8349125
• 关键词: Affect; Benign; Biopsy; Cells; Characteristics; Clinic; Clinical; Clinical Protocols; Clinical Research; Collaborations; Cutaneous Melanoma; DNA Repair; Dermatology; Dermoscopy; Development; Devices; Doctor of Medicine; Doctor of Philosophy; Epigenetic Process; Evaluation; Family member; General Population; Goals; Hereditary Disease; Image; Incidence; Individual; Laboratories; Lesion; Malignant - descriptor; Melanocytic nevus; Microscopy; Mole the mammal; Patients; Pigments; Principal Investigator; Protocols documentation; Recruitment Activity; Skin; Skin Cancer; Structure; Techniques; Time; Tissues; United States National Institutes of Health; Visual; Work; Xeroderma Pigmentosum; digital; melanoma; novel; skin lesion

The scope of this project is limited to describing visual characteristics corresponding to various types of pigmented lesions in common, acquired melanocytic nevi and in patients with the rare genetic disease xeroderma pigmentosum. Under the auspices of clinical protocol 06-C-0060 (Thomas J. Hornyak, M.D., Ph.D., Principal Investigator), patients are recruited to the Dermatology Clinic for study and tissue acquisition of melanocytic nevi. Selected lesions are imaged with digital epiluminescent microscopy using a device, the digital dermatoscope, that permits evaluation of these lesions under illuminated magnification. Certain structures correlated with benign or malignant pigmented lesions can be observed with this technique. We collect images of lesions over time and analyze them for changes and for the presence of novel structures that can be correlated with specific types or arrangements of cells histopathologically. Also, in collaboration with Drs. Kenneth Kraemer and John DiGiovanna of the Dermatology Branch, we have obtained digital dermatoscopic images of biopsied pigmented skin lesions on approximately 20 patients with xeroderma pigmentosum. These patients have been seen at the NIH Clinical Center under the auspices of Dr. Kraemer's clinical protocol focused upon xeroderma pigmentosum. Currently the greater than twenty lesions whose information has been obtained from these patients are being analyzed, using standard dermatoscopic criteria, for features that may permit whether they can be classified clinically as malignant or benign. In addition, dermatoscopic evaluation of selected pigmented lesions on family members of those affected with xeroderma pigmentosum is sometimes performed.

本项目的范围仅限于描述与常见的各种类型色素性病变、获得性黑色素细胞痣和罕见遗传性疾病着色性干皮病患者相对应的视觉特征。 在临床方案06-C-0060（托马斯J. Hornyak，医学博士，哲学博士、主要研究者），患者被招募到皮肤科诊所进行黑色素细胞痣的研究和组织采集。选定的病变成像与数字发光显微镜使用的设备，数字皮肤镜，允许这些病变的照明放大率下的评价。与良性或恶性色素性病变相关的某些结构可以用这种技术观察到。我们随着时间的推移收集病变的图像，并分析它们的变化以及与组织病理学细胞的特定类型或排列相关的新结构的存在。 此外，我们与皮肤科分支的Kenneth Kraemer和John DiGiovanna博士合作，获得了大约20名着色性干皮病患者活检色素性皮肤病变的数字皮肤镜图像。这些患者已经在美国国立卫生研究院临床中心的主持下，克雷默博士的临床协议，重点是着色性干皮病。目前，正在使用标准皮肤镜标准分析从这些患者中获得信息的20多个病变，以确定其特征是否可以在临床上分类为恶性或良性。此外，皮肤镜评价选定的色素性病变的家庭成员受影响的着色性干皮病有时进行。