Dermatoscopy in the Evaluation of Pigmented Lesions

该项目的范围仅限于描述与常见的各种类型的色素病变、获得性黑素细胞痣和罕见遗传病色素性干皮病患者相对应的视觉特征。 在临床方案 06-C-0060（Thomas J. Hornyak，医学博士、博士，首席研究员）的支持下，患者被招募到皮肤科诊所进行黑素细胞痣的研究和组织采集。使用数字皮肤镜设备通过数字落光显微镜对选定的病变进行成像，该设备允许在照明放大倍率下评估这些病变。使用这种技术可以观察到与良性或恶性色素病变相关的某些结构。我们随着时间的推移收集病变图像，并分析它们的变化以及可能与组织病理学上细胞的特定类型或排列相关的新结构的存在。 此外，与博士合作。在皮肤科的 Kenneth Kraemer 和 John DiGiovanna 的带领下，我们获得了约 20 名色素性干皮病患者的活检色素性皮肤病变的数字皮肤镜图像。在 Kraemer 博士针对着色性干皮病的临床方案的支持下，这些患者在 NIH 临床中心接受了治疗。目前，正在使用标准皮肤镜标准对从这些患者获得信息的二十多个病变进行分析，以了解可能允许在临床上将其分类为恶性或良性的特征。此外，有时会对着色性干皮病患者的家庭成员进行选定的色素病变的皮肤镜评估。

The scope of this project is limited to describing visual characteristics corresponding to various types of pigmented lesions in common, acquired melanocytic nevi and in patients with the rare genetic disease xeroderma pigmentosum. Under the auspices of clinical protocol 06-C-0060 (Thomas J. Hornyak, M.D., Ph.D., Principal Investigator), patients are recruited to the Dermatology Clinic for study and tissue acquisition of melanocytic nevi. Selected lesions are imaged with digital epiluminescent microscopy using a device, the digital dermatoscope, that permits evaluation of these lesions under illuminated magnification. Certain structures correlated with benign or malignant pigmented lesions can be observed with this technique. We collect images of lesions over time and analyze them for changes and for the presence of novel structures that can be correlated with specific types or arrangements of cells histopathologically. Also, in collaboration with Drs. Kenneth Kraemer and John DiGiovanna of the Dermatology Branch, we have obtained digital dermatoscopic images of biopsied pigmented skin lesions on approximately 20 patients with xeroderma pigmentosum. These patients have been seen at the NIH Clinical Center under the auspices of Dr. Kraemer's clinical protocol focused upon xeroderma pigmentosum. Currently the greater than twenty lesions whose information has been obtained from these patients are being analyzed, using standard dermatoscopic criteria, for features that may permit whether they can be classified clinically as malignant or benign. In addition, dermatoscopic evaluation of selected pigmented lesions on family members of those affected with xeroderma pigmentosum is sometimes performed.