Neuroimaging Core Facility

神经影像核心设施

• 批准号: 8342307
• 负责人: Daniel Weinberger
• 金额: $ 51.26万
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8342307
• 关键词: Affect; Biological; Brain; Brain Diseases; Clinical; Clinical Investigator; Cognition; Complex; Computers; Copying Processes; Core Facility; Data; Data Analyses; Data Set; Diagnostic Procedure; Diffusion Magnetic Resonance Imaging; Equipment; Functional Magnetic Resonance Imaging; Galvanic Skin Response; Genes; Genetic Variation; Genomics; Goals; Image; Image Analysis; Imaging Techniques; Inpatients; Intervention; Knowledge; Laboratories; MRI Scans; Magnetic Resonance Imaging; Maintenance; Manuals; Measurement; Measures; Medical; Mental disorders; Methods; Modality; Multimodal Imaging; Patients; Phenotype; Physicians; Physiological; Procedures; Productivity; Protocols documentation; Psychotic Disorders; Pulse Pressure; Quality Control; Relative (related person); Research; Research Personnel; Schizophrenia; Services; Siblings; Specialist; Spectrum Analysis; Supervision; Surface; Techniques; Training; United States National Institutes of Health; Update; base; computerized data processing; data mining; distributed data; high standard; improved; interest; neuroimaging; operation; programs

The GCAP Neuroimaging Core implements quality control procedures, optimizes and updates imaging protocols, and collects all clinical imaging data from the CBDB sibling and inpatient studies, and maintains and analyzes all structural, spectroscopy, DTI, and large scale archival fMRI data used in these studies. The Neuroimaging Core covers the following neuroimaging domains: 1. Structural MRI: acquisition, quality control, segmentation, automated and manual regions-of-interest (ROI) definition and measurements, surface extraction; 2. Functional MRI: acquisition, quality control, preprocessing, standardized analyses; 3. Spectroscopy: acquisition, quality control, preprocessing, ROI-based and voxel-based; 4. DTI: acquisition, quality control, preprocessing; 5. Implementing new MRI techniques. The Neuroimaging Core subserves the following functions: 1. Medical coverage and image acquisition, image quality control (for data acquired by the core); 2. Maintenance of stimulation equipment, liaison with other NIH imaging core facilities; 3. Implementing and maintaining acquisition of physiological measurements and interventions, (e.g. galvanic skin response, pupillometry, pulse pressure); 4. Creates and updates a manual of MR acquisition and data analysis methods; 5. Training and supervising of research assistants and fellows in neuroimaging methods and analysis; 6. Perform standardized analyses and analysis quality control; and 7. Data mining and distributing of raw and processed data to GCAP investigators; integration with genomic and other scientific data maintained within GCAP. It is expected that other imaging studies performed in GCAP may use the Neuroimaging Core protocols and facilities for those parts (such as structural MRI scanning) it can perform to facilitate integrating and relating these data to the larger archival datasets. To function clinically, the core requires the participation of several staff physicians to perform data mining and analysis functions; requires computer specialists, and a fairly large group of research assistants who rotate between imaging and image analyses and are trained to maintain a standard level of knowledge in imaging and analysis. Day-to-day operation of the core is overseen by the Director of the Neuroimaging Core. Neuroimaging Core's strategy and supervision is under the direction of the Director of the Genes, Cognition and Psychosis Program and a panel consisting of clinical investigators and the Clinical and Scientific Directors.

GCAP Neuroimaging Core实施质量控制程序，优化和更新成像方案，并从CBDB兄弟和住院研究中收集所有临床成像数据，并维护和分析这些研究中使用的所有结构，光谱，DTI和大规模存档fMRI数据。 神经影像学核心涵盖以下神经影像学领域： 1.结构MRI：采集、质量控制、分割、自动和手动感兴趣区域（ROI）定义和测量、表面提取; 2.功能磁共振成像：采集、质量控制、预处理、标准化分析; 3.光谱学：采集、质量控制、预处理、基于ROI和基于体素; 4. DTI：采集、质量控制、预处理; 5.采用新的MRI技术。 Neuroimaging Core具有以下功能： 1.医疗保险和图像采集、图像质量控制（针对核心采集的数据）; 2.刺激设备的维护，与其他NIH成像核心设施的联络; 3.实施和维护生理测量和干预的采集（例如皮肤电反应、瞳孔测量、脉搏压力）; 4.创建并更新MR采集和数据分析方法手册; 5.在神经成像方法和分析方面培训和指导研究助理和研究员; 6.进行标准化分析和分析质量控制;以及 7.数据挖掘并将原始数据和处理后的数据分发给GCAP研究者;与GCAP内维护的基因组数据和其他科学数据整合。 预计在GCAP中进行的其他成像研究可能会使用神经成像核心方案和设施，以便于将这些数据整合并关联到更大的存档数据集。 为了在临床上发挥作用，核心需要几名工作人员医生的参与来执行数据挖掘和分析功能;需要计算机专家和相当大的一组研究助理，他们在成像和图像分析之间轮换，并接受培训以保持成像和分析的标准知识水平。核心的日常运作由神经影像核心主任监督。 神经影像核心的战略和监督是在基因，认知和精神病计划主任和一个由临床研究人员和临床和科学主任组成的小组的指导下。