Understanding Emotion and Social Impairment in Schizophrenia

了解精神分裂症的情绪和社交障碍

• 批准号: 8246422
• 负责人: JACK J. BLANCHARD
• 金额: $ 12.64万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-08 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8246422
• 关键词: 18 year old; Adult; Affect; Affective; Anhedonia; Area; Basic Science; Behavior; Behavioral; Characteristics; Clinical; Clip; Collaborations; Communities; Complement; Consult; Consultations; Coupled; Development; Development Plans; Disease; Educational workshop; Electroencephalography; Emotional; Emotions; Family Relationship; Film; Food; Foxes; Functional disorder; Funding; Future; Goals; Impairment; Independent Scientist Award; Individual Differences; Intervention; Left; Longitudinal Studies; Maryland; Mentors; Methods; Neurocognitive Deficit; Neurosciences; Neurosciences Research; Outcome; Patient Self-Report; Pattern; Performance; Procedures; Psychophysiology; Relative (related person); Research; Research Activity; Research Methodology; Research Personnel; Risk; Role; Sampling; Schizophrenia; Social Behavior; Social Interaction; Social support; Socialization; Stimulus; Sum; Temperament; Testing; Time; Training; Translational Research; Withdrawal; affection; affective neuroscience; base; career development; cohort; developmental psychology; follow-up; indexing; meetings; neuropsychological; peer; response; skills; social; social group; social neuroscience; trait; young adult

DESCRIPTION (provided by applicant): This is an application for an Independent Scientist Award (K02) that would enable the PI to further develop his research on emotional and social impairment within schizophrenia. The career development plan will allow the PI to obtain training in affective and social neuroscience research that can then serve as the basis for additional translational research in the study and treatment of schizophrenia. This training will involve the following interrelated areas: developmental perspectives on peer relationship formation and socialization, developmental approaches to the understanding of individual differences in temperament and emotion, psychophysiological methods in the study of emotion, and social neuroscience approaches to the study of social behavior and emotion. These career development goals will be met through consultation, research activities, and collaborations with senior researchers in the areas of developmental psychology, basic emotion research, and social neuroscience. Classroom and technical training as well as attendance at scientific meetings and workshops will complement these consulting activities. The proposed didactic and career development activities are closely coupled with the research plan that is, in part, based on the PI's current funded research on anhedonia in schizophrenia and schizotypy (R01 MH512460). Ongoing and planned research will focus on understanding how emotion is altered in schizotypy and schizophrenia including how these emotional changes contribute to disturbances in affiliation and resulting social impairment. This research will span community samples involving schizophrenia-spectrum disorders as well as planned studies on schizophrenia. In sum, an Independent Scientist Award will provide the needed protected time for the PI to develop new skills in the study of emotion and social behavior from a basic science perspective. These new skills will be applied by the PI to future translational research aimed at understanding the profound emotional and social deficits occurring in schizophrenia and will have direct benefit to the development of future interventions in schizophrenia.

描述（由申请人提供）：这是一个独立科学家奖（K02）的申请，它将使PI能够进一步发展他对精神分裂症中情感和社会障碍的研究。职业发展计划将使PI获得情感和社会神经科学研究的培训，然后可以作为精神分裂症研究和治疗的其他转化研究的基础。这项培训将涉及以下相互关联的领域：关于同伴关系形成和社会化的发展观点，发展情感和情感中个体差异的发展方法，情感研究中的心理生理方法以及社会神经科学方法研究社会行为和情感。这些职业发展目标将通过咨询，研究活动以及与发展心理学，基本情感研究和社会神经科学领域的高级研究人员的合作实现。课堂和技术培训以及参加科学会议和研讨会的参加将补充这些咨询活动。拟议的教学和职业发展活动与研究计划紧密相结合，该计划部分基于PI目前对精神分裂症和精神分裂症的Anhedonia的资助研究（R01 MH512460）。正在进行的研究和计划的研究将集中在理解精神分裂症和精神分裂症中如何改变情感，包括这些情绪变化如何导致隶属关系的干扰以及导致的社会障碍。这项研究将涵盖涉及精神分裂症谱系疾病的社区样本以及对精神分裂症的计划研究。总而言之，独立科学家奖将为PI提供所需的保护时间，从基础科学的角度来研究情感和社会行为方面的新技能。这些新技能将被PI应用于未来的转化研究，旨在了解精神分裂症中出现的深刻的情感和社会缺陷，并将直接利用精神分裂症的未来干预措施的发展。

项目成果

Social anhedonia and affiliation: examining behavior and subjective reactions within a social interaction.

社交快感缺乏和归属感：检查社交互动中的行为和主观反应。

• DOI: 10.1016/j.psychres.2012.07.050
• 发表时间: 2012
• 期刊: Psychiatry research
• 影响因子: 11.3
• 作者: Llerena,Katiah;Park,StephanieG;Couture,ShannonM;Blanchard,JackJ
• 通讯作者: Blanchard,JackJ

Is social anhedonia related to emotional responsivity and expressivity? A laboratory study in women.

• DOI: 10.1016/j.schres.2010.06.012
• 发表时间: 2010-12
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Leung, Winnie W.;Couture, Shannon M.;Blanchard, Jack J.;Lin, Stephanie;Llerena, Katiah
• 通讯作者: Llerena, Katiah