Understanding Emotion and Social Impairment in Schizophrenia

描述（由申请人提供）：这是一份独立科学家奖（K02）的申请，将使PI能够进一步发展他对精神分裂症中情感和社会障碍的研究。职业发展计划将使PI获得情感和社会神经科学研究方面的培训，然后可以作为精神分裂症研究和治疗方面的额外转化研究的基础。本培训将涉及以下相关领域：同伴关系形成和社会化的发展观点，气质和情感个体差异理解的发展方法，情感研究的心理生理学方法，以及社会行为和情感研究的社会神经科学方法。这些职业发展目标将通过咨询、研究活动和与发展心理学、基础情感研究和社会神经科学领域的高级研究人员的合作来实现。课堂和技术培训以及参加科学会议和讲习班将补充这些咨询活动。拟议的教学和职业发展活动与研究计划密切相关，该计划部分基于PI目前资助的关于精神分裂症和分裂型中的快感缺乏的研究（R01 MH512460）。正在进行的和计划中的研究将集中于理解精神分裂型和精神分裂症患者的情绪是如何改变的，包括这些情绪变化是如何导致交往障碍和由此导致的社会障碍的。这项研究将涵盖社区样本，包括精神分裂症谱系障碍以及计划中的精神分裂症研究。总而言之，独立科学家奖将为PI提供必要的保护时间，从基础科学的角度发展情感和社会行为研究的新技能。这些新技能将被PI应用于未来的转化研究，旨在理解精神分裂症中发生的深刻的情感和社会缺陷，并将直接有利于未来精神分裂症干预措施的发展。

DESCRIPTION (provided by applicant): This is an application for an Independent Scientist Award (K02) that would enable the PI to further develop his research on emotional and social impairment within schizophrenia. The career development plan will allow the PI to obtain training in affective and social neuroscience research that can then serve as the basis for additional translational research in the study and treatment of schizophrenia. This training will involve the following interrelated areas: developmental perspectives on peer relationship formation and socialization, developmental approaches to the understanding of individual differences in temperament and emotion, psychophysiological methods in the study of emotion, and social neuroscience approaches to the study of social behavior and emotion. These career development goals will be met through consultation, research activities, and collaborations with senior researchers in the areas of developmental psychology, basic emotion research, and social neuroscience. Classroom and technical training as well as attendance at scientific meetings and workshops will complement these consulting activities. The proposed didactic and career development activities are closely coupled with the research plan that is, in part, based on the PI's current funded research on anhedonia in schizophrenia and schizotypy (R01 MH512460). Ongoing and planned research will focus on understanding how emotion is altered in schizotypy and schizophrenia including how these emotional changes contribute to disturbances in affiliation and resulting social impairment. This research will span community samples involving schizophrenia-spectrum disorders as well as planned studies on schizophrenia. In sum, an Independent Scientist Award will provide the needed protected time for the PI to develop new skills in the study of emotion and social behavior from a basic science perspective. These new skills will be applied by the PI to future translational research aimed at understanding the profound emotional and social deficits occurring in schizophrenia and will have direct benefit to the development of future interventions in schizophrenia.