Understanding Emotion and Social Impairment in Schizophrenia

简介(申请人提供)：这是一份申请独立科学家奖(K02)的申请书，将使PI能够进一步发展他对精神分裂症中情绪和社会损害的研究。职业发展计划将使PI能够获得情感和社会神经科学研究方面的培训，然后作为研究和治疗精神分裂症的更多翻译研究的基础。这项培训将涉及以下相互关联的领域：关于同伴关系形成和社会化的发展观点；了解个人气质和情绪差异的发展方法；研究情绪的心理生理学方法；以及研究社会行为和情绪的社会神经科学方法。这些职业发展目标将通过咨询、研究活动以及与发展心理学、基础情绪研究和社会神经科学领域的高级研究人员的合作来实现。课堂和技术培训以及参加科学会议和讲习班将补充这些咨询活动。拟议的教学和职业发展活动与研究计划密切相关，研究计划部分基于国际精神病院目前资助的精神分裂症和分裂型快感缺乏症研究(R01 MH512460)。正在进行和计划中的研究将集中于了解分裂型和精神分裂症患者的情绪是如何改变的，包括这些情绪变化如何导致依恋障碍和由此导致的社会损害。这项研究将涵盖涉及精神分裂症谱系障碍的社区样本，以及计划中的精神分裂症研究。总而言之，独立科学家奖将为PI提供必要的保护时间，以从基础科学的角度发展新的情感和社会行为研究技能。这些新技能将被PI应用于未来的转译研究，旨在了解精神分裂症发生的深刻情感和社会缺陷，并将对未来精神分裂症干预措施的发展产生直接好处。

DESCRIPTION (provided by applicant): This is an application for an Independent Scientist Award (K02) that would enable the PI to further develop his research on emotional and social impairment within schizophrenia. The career development plan will allow the PI to obtain training in affective and social neuroscience research that can then serve as the basis for additional translational research in the study and treatment of schizophrenia. This training will involve the following interrelated areas: developmental perspectives on peer relationship formation and socialization, developmental approaches to the understanding of individual differences in temperament and emotion, psychophysiological methods in the study of emotion, and social neuroscience approaches to the study of social behavior and emotion. These career development goals will be met through consultation, research activities, and collaborations with senior researchers in the areas of developmental psychology, basic emotion research, and social neuroscience. Classroom and technical training as well as attendance at scientific meetings and workshops will complement these consulting activities. The proposed didactic and career development activities are closely coupled with the research plan that is, in part, based on the PI's current funded research on anhedonia in schizophrenia and schizotypy (R01 MH512460). Ongoing and planned research will focus on understanding how emotion is altered in schizotypy and schizophrenia including how these emotional changes contribute to disturbances in affiliation and resulting social impairment. This research will span community samples involving schizophrenia-spectrum disorders as well as planned studies on schizophrenia. In sum, an Independent Scientist Award will provide the needed protected time for the PI to develop new skills in the study of emotion and social behavior from a basic science perspective. These new skills will be applied by the PI to future translational research aimed at understanding the profound emotional and social deficits occurring in schizophrenia and will have direct benefit to the development of future interventions in schizophrenia.