Vascular Biology Training Grant

描述（由申请人提供）：血管生物学的研究已经在我们如何预防，监测和治疗心血管疾病的显着变化负责。在过去的50年里，我们见证了患者护理的转变，预期寿命的增加和血管疾病患者生活质量的改善。正是通过培训下一代，我们取得了这些成就，也正是通过培训，我们将继续在预防和保健方面作出进一步的改进。本申请要求资金继续对血管生物学研究生和博士后进行跨学科培训。特别是我们的目标是培养科学家谁可以：（1）“说”各种语言（代谢组学，病理学，分子生物学，基因组学和生物数学），（2）整合信息和思考（3）解决真实的临床问题。为了实现这些目标，我们开发了一种多导师的方法，新颖的教学组件，并将互动式的医学接触纳入培训的结构。加州大学洛杉矶分校拥有大量跨学科团体资源，其研究重点是血管生物学。该小组包括27个实验室，目前为124名研究生和博士后研究员提供培训。正是这个社区构成了下一代血管生物学研究人员独特培训计划的支柱。作为洛杉矶唯一的血管生物学培训补助金和加州四分之一的补助金，自2002年以来，我们已经培训了28名研究生和博士后研究员。这些已经产生了101同行评议的出版物，而在该计划和9已经取得进展，发展独立的研究小组在全国各地的行业和大学。此外，与培训计划相关的活动促进了团体之间的互动，加强了合作活动。平均每年有10份同行评审出版物显示有两个或更多实验室参与。在这里，我们要求资助7个前和3个博士后研究员/年，其中2-3个新的研究生和1或2个博士后研究员每年将进入该计划。我们的目标也是积极寻求和促进代表性不足的少数群体的培训和参与（自2002年以来，我们有21%的少数民族学员代表）。这是该计划的一个重要目标是在血管生物学教育创新的前沿，重点是研究诚信和道德。在这次更新中，我们提出了几项新战略的实施，以实现这些目标，并进一步提高少数民族的参与和血管研究培训的质量。这一培训计划的成功引起了加州大学洛杉矶分校医学院，文学与科学学院和研究生部的热情，所有这些都致力于为VBTP开发的活动提供额外的机构支持。

DESCRIPTION (provided by applicant): Research in vascular biology has been responsible for remarkable changes in how we prevent, monitor and treat cardiovascular disease. The last fifty years have witnessed a transformation in patient care, increase in life expectancy and improvement in the quality of lives of those afflicted with vascular problems. It is through training of the next generation that we have made these achievements and it is through training that we will continue to make additional improvements in prevention and health care. The present application request funds to continue the interdisciplinary training of graduate students and post-doctoral fellows in vascular biology. In particular we aim at developing scientists who can: (1) "speak" various languages (metabolomics, pathology, molecular biology, genomics, and biomathematics), (2) integrate information and think towards (3) solving real clinical problems. To achieve these goals we have developed a multi-mentorship approach, novel didactic components and incorporated an interactive exposure to medicine into the structure of the training. UCLA houses a tremendous resource of interdisciplinary groups whose research focuses in vascular biology. The group includes 27 laboratories that currently offer training to 124 graduate students and post-doctoral fellows. It is this community that constitutes the pillars of a unique training program for the next generation of investigators in vascular biology. Being the only Vascular Biology Training grant in Los Angeles and one in four in California, we have trained 28 graduate students and post-doctoral fellows since 2002. These have produced 101 peer-reviewed publications while in the program and 9 have progressed to develop independent research groups in industry and universities across the nation. Furthermore, the activities associated with the training program have catalyzed interactions between groups intensifying collaborative activities. On the average 10 peer reviewed publications show the participation of two or more laboratories each year. Here, we request funding for 7 pre and 3 post-doctoral fellows / year, in which 2-3 new graduate students and either 1 or 2 post-doctoral fellows will enter the program each year. It is also our goal to actively seek and promote training and engagement of underrepresented minority groups (since 2002 we have a 21% minority trainee representation). It is an important objective of this program to be at the forefront of innovation in vascular biology education with strong emphasis in research integrity and ethics. In this current renewal we proposed the implementation of several new strategies to attain these goals and further improve the participation of minorities and the quality of training in vascular research. The success of this training program has engendered enthusiasm by the School of Medicine, College of Letters and Sciences and the Graduate Division at UCLA all of which have committed to provide additional institutional support towards activities developed by the VBTP.