R&D-OTHER R & D-B RES

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• 批准号: 8337038
• 负责人: CLARK ALGAIER
• 金额: $ 338万
• 依托单位: MIDWEST RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8337038
• 关键词: Adverse effects; Analytical Chemistry; Biological; Chemicals; Chloride Ion; Chlorides; Contracts; Corn Oil; Cremophor; Dermal; Development; Dimethyl Sulfoxide; Dose; Drug Formulations; Ensure; Environmental Exposure; Ethanol; Evaluation; Exposure to; Flame Retardants; Gas-Liquid Chromatography; Glucuronides; Goals; Hazard Identification; Hazardous Chemicals; Health; Heightened Cancer Risk; Human; Hypersensitivity skin testing; Immunotoxicology; Isomerism; Laboratory Research; Light; Liquid substance; Mass Spectrum Analysis; Methods; Methylcellulose; National Toxicology Program; Nuclear Magnetic Resonance; Oils; Outcome; Paraffin; Polysorbate 80; Research Personnel; Risk Assessment; Risk Factors; Rodent; Sampling; Services; Specific qualifier value; Testing; Toxic effect; Toxicity Tests; Toxicology; United States; Water; aqueous; bisphenol A; carcinogenesis; disorder prevention; feeding; inorganic phosphate; programs; public health research; reproductive; research and development; sound

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the prescribed chemicals at the specified dose concentrations. This contract contributes to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing characterization of the chemicals studied, confirmation of the dose levels administered, and internal dose determinations. This information is critical to evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. With internal dose information provided by this contract, extrapolations to humans can be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals.

该项目的目标是为国家毒理学计划 (NTP) 危害识别活动提供支持，旨在预防因环境暴露于化学或物理制剂而引起的疾病或不利影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于识别对人类健康有害的化学品。需要进行适当的化学分析，以确保在毒性研究中，测试物种以指定的剂量浓度暴露于规定的化学品。该合同通过提供所研究化学品的特性、给药剂量水平的确认以及内部剂量测定，有助于毒性研究提供癌症风险增加的证据以及其他毒理学结果。这些信息对于评估毒性测试以及得出有关研究化学品在测试物种中的潜在毒性的合理、科学结论至关重要，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。利用本合同提供的内部剂量信息，可以对人类进行推断，以便公众能够充分了解因接触所研究化学品而产生的风险因素。