CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENTAL TOXICOLOGY PROGRAM

环境毒理学计划的化学支持服务

• 批准号: 8008908
• 负责人: CLARK ALGAIER
• 金额: $ 310.6万
• 依托单位: MIDWEST RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8008908
• 关键词: Acetylcysteine; Acids; Affect; Animals; Baltimore; Biological; Biological Assay; Bis-DMA; Bisphenol A-Glycidyl Methacrylate; Cell Proliferation; Cells; Chemical Agents; Chemicals; Chemistry; Chloride Ion; Chlorides; Code; Commiphora mukul; Complex; Complex Mixtures; Corn Oil; Dental; Detection; Development; Diet; Dipeptides; Dose; Drug Formulations; Environment; Estrogen Receptors; Ethers; Evaluation; Exposure to; Feeds; Fertilizers; Filler; Flame Retardants; Food; Gas Chromatography; Glycine; Health; High Pressure Liquid Chromatography; Home environment; Human; International; Isomerism; Italy; Japan; Life; Lipids; Liquid Chromatography; Liquid substance; MCF7 cell; Malignant neoplasm of prostate; Marketing; Mass Spectrum Analysis; Membrane; Methods; Methylcellulose; Mixed Function Oxygenases; Mus; NMR Spectroscopy; National Toxicology Program; Organic Chemicals; Peroxides; Pesticides; Pit and Fissure Sealants; Plant Resins; Plants; Poison; Proteins; Rattus; Reaction; Receptor Cell; Rodent; Saliva; Salmonella; Sampling; Screening procedure; Serum; Services; Shipping; Ships; Silanes; Societies; Solubility; Solutions; Solvents; Spectroscopy, Fourier Transform Infrared; Steroids; Support Groups; Testing; Tissues; Toxic effect; Toxicity Tests; Toxicology; Urine; Validation; Water; analytical method; bisphenol A; cancer cell; chemical property; environmental toxicology; estrogenic activity; ethylene dimethacrylate; feeding; flexibility; gugulu extract; high throughput screening; infrared spectroscopy; inorganic phosphate; instrument; meetings; method development; n-butyl glycidyl ether; physical property; polyurethane foam; posters; programs; research study; silane; toxicant; triethylene glycol dimethacrylate; validation studies; valyltyrosine; water testing

Toxicological evaluation of chemicals/materials that may affect human health is an important aspect of public health research. The purpose of this contract is to support the National Toxicology Program (NTP) in its efforts to identify and assess chemical agents potentially affecting human health through environmental exposure. This contract provides information on comprehensive chemical characterization, purity determination, confirmation of administered dose levels, and internal dose determinations. This information is critical for sound and scientific conclusions and supports the risk assessment efforts of NTP and other federal agencies. With internal dose information provided by this contract, extrapolations to humans can be made so that the public can be adequately informed about risk factors associated with the exposure with these chemicals. A wide variety of chemicals/test articles are studied by NTP, for example: solvents, plasticizer, flame retardants, dietary/herbal supplements, and sunscreen. The chemistry support contract provides NTP with chemical procurement, dose formulations and analysis, bulk chemical comprehensive analysis of bulk material, along with biological sample method evaluation as well as studies to determine internal dose and other toxicokinetic parameters.

对可能影响人类健康的化学品/材料进行毒理学评价是公共卫生研究的一个重要方面。该合同的目的是支持国家毒理学计划 (NTP) 努力识别和评估通过环境暴露可能影响人类健康的化学制剂。该合同提供了有关综合化学特性、纯度测定、给药剂量水平确认和内部剂量测定的信息。这些信息对于得出合理、科学的结论至关重要，并支持 NTP 和其他联邦机构的风险评估工作。根据本合同提供的内部剂量信息，可以对人类进行推断，以便公众能够充分了解与接触这些化学品相关的风险因素。 NTP 研究了多种化学品/测试物品，例如：溶剂、增塑剂、阻燃剂、膳食/草药补充剂和防晒霜。化学支持合同为 NTP 提供化学品采购、剂量配方和分析、散装材料的散装化学综合分析、生物样品方法评估以及确定内部剂量和其他毒代动力学参数的研究。