TAS::75 0862::TAS ANALYTICAL CHEMISTRY SERVICES FOR THE NTP

TAS::75 0862::TAS 为 NTP 提供的分析化学服务

• 批准号: 8341297
• 负责人: STEVEN GRAVES
• 金额: $ 46.93万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8341297
• 关键词: Address; Analytical Chemistry; Biological; Breathing; Caliber; Carbon Nanotubes; Chemicals; Chemistry; Chronic; Development; Dose; Drug Formulations; Goals; Hazard Assessment; Health Hazards; Human; Inhalation Exposure; Length; Nanotechnology; National Toxicology Program; Research; Research Project Grants; Sampling; Services; Testing; Toxic effect; base; comparative; fullerene C60; method development; nano; nanomaterials; programs; response; titanium dioxide

The National Toxicology Program (NTP) is developing a broad-based research program to address potential human health hazards associated with the manufacture and use of nanomaterials. This initiative is driven by the intense current and anticipated future research and development focus on nanotechnology. The goal of these studies is to provide sufficient dose response information on a defined set of nanomaterials with characterized lengths and diameters to allow the development of quantitative hazard assessments for inhalation exposures of these materials. It was proposed to develop a broad based research project to evaluate the comparative inhalation toxicity after subchronic and chronic exposure of different nano materials. In support of NTPs goal following various chemistry tests are performed on different test articles (multiwalled carbon nanotubes, fullerene C60, titanium dioxide). The tasks includes, bulk material procurement and analysis, method development & chemical analysis, dose formulation development, biological sample method development & analysis, etc.

美国国家毒理学计划(NTP)正在制定一项基础广泛的研究计划，以解决与纳米材料的制造和使用有关的潜在人类健康危害。这一倡议是由目前和预计未来对纳米技术的研究和开发的强烈关注推动的。这些研究的目的是提供关于一组具有特定长度和直径的纳米材料的足够剂量反应信息，以便开发对这些材料吸入暴露的定量危险评估。有人建议制定一个基础广泛的研究项目，以评估比较 不同纳米材料亚慢性和慢性暴露后的吸入毒性。为了支持NTPS的目标，对不同的测试物品(多壁碳纳米管、富勒烯C60、二氧化钛)进行了各种化学测试。主要工作包括：大宗材料采购和分析、方法开发和化学分析、剂量配方开发、生物样品方法开发和分析等。