Nano Material Initiative

国家毒理学计划（NTP）正在制定一项基础广泛的研究计划，以解决与纳米材料的制造和使用相关的潜在人类健康危害。这一举措是由目前和预期的未来对纳米技术的研究和开发重点推动的。这些研究的目的是提供关于一组具有特征长度和直径的定义纳米材料的足够剂量反应信息，以便对这些材料的吸入暴露进行定量危害评估。建议制定一个基础广泛的研究项目， 不同纳米材料亚慢性和慢性暴露后的吸入毒性。为了支持NTP目标，对不同的供试品（多壁碳纳米管、富勒烯C60、二氧化钛）进行了以下各种化学试验。主要工作包括：原料采购和分析、方法开发和化学分析、给药制剂开发、生物样品方法开发和分析等。

The National Toxicology Program (NTP) is developing a broad-based research program to address potential human health hazards associated with the manufacture and use of nanomaterials. This initiative is driven by the intense current and anticipated future research and development focus on nanotechnology. The goal of these studies is to provide sufficient dose response information on a defined set of nanomaterials with characterized lengths and diameters to allow the development of quantitative hazard assessments for inhalation exposures of these materials. It was proposed to develop a broad based research project to evaluate the comparative inhalation toxicity after subchronic and chronic exposure of different nano materials. In support of NTPs goal following various chemistry tests are performed on different test articles (multiwalled carbon nanotubes, fullerene C60, titanium dioxide). The tasks includes, bulk material procurement and analysis, method development & chemical analysis, dose formulation development, biological sample method development & analysis, etc.