MOUSE MODEL FOR CYTOGENETIC DISORDERS

细胞遗传学疾病小鼠模型

• 批准号: 8332228
• 负责人: CATHLEEN LUTZ
• 金额: $ 65万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-23 至 2015-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8332228
• 关键词: Animal Model; Animal Testing; Breeding; Chromosomes, Human, Pair 10; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 17; Communities; Cytogenetics; Disease; Down Syndrome; Embryo; Freezing; Genetic; Germ Cells; Maine; Maintenance; Mouse Strains; Mus; National Institute of Child Health and Human Development; Procedures; Qualifying; Research; Research Personnel; Resources; Robertsonian Translocation; The Jackson Laboratory; Transgenic Mice; Trisomy; Writing; clinical phenotype; improved; mouse model; mutant; pathogen; programs; repository

To improve understanding of cytogenetic disorders, the NICHD provides ongoing support for a specialized respository that provides the scientific community with increasing numbers of mice with specific partial trisomies involving mouse chromosome 16, mouse chromosome 17, and mouse chromosome 10, specific Robertsonian translocation stocks, and, if appropriate specific mutant and transgenic mouse stocks relevant to Down syndrome research.

为了提高对细胞遗传学疾病的了解，NICHD为专门的储存库提供持续的支持，该储存库为科学界提供越来越多的小鼠具有涉及小鼠16号染色体、17号小鼠染色体和10号小鼠染色体的特定部分三体、特定的罗伯逊易位种群，以及在适当的情况下与唐氏综合症研究相关的特定突变和转基因小鼠种群。